Gene Review:
KAT2B - K(lysine) acetyltransferase 2B
Homo sapiens
Synonyms:
CAF, GCN5, GCN5L, Histone acetylase PCAF, Histone acetyltransferase KAT2B, ...
Watts,
Oshiro,
Junk,
Wozniak,
Watterson,
Domann,
Futscher,
Le Cam,
Linares,
Paul,
Julien,
Lacroix,
Hatchi,
Triboulet,
Bossis,
Shmueli,
Rodriguez,
Coux,
Sardet,
Herrera,
Sakaguchi,
Bergel,
Trieschmann,
Nakatani,
Bustin,
Bannert,
Muranyi,
Ogryzko,
Nakatani,
Flügel,
Brockmann,
Lehmkühler,
Schmücker,
Esche,
- Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain. Mujtaba, S., He, Y., Zeng, L., Farooq, A., Carlson, J.E., Ott, M., Verdin, E., Zhou, M.M. Mol. Cell (2002)
- Transcriptional synergy between Tat and PCAF is dependent on the binding of acetylated Tat to the PCAF bromodomain. Dorr, A., Kiermer, V., Pedal, A., Rackwitz, H.R., Henklein, P., Schubert, U., Zhou, M.M., Verdin, E., Ott, M. EMBO J. (2002)
- Adenovirus E1B 55-kilodalton oncoprotein inhibits p53 acetylation by PCAF. Liu, Y., Colosimo, A.L., Yang, X.J., Liao, D. Mol. Cell. Biol. (2000)
- The acetyltransferase p300/CBP-associated factor is a p53 target gene in breast tumor cells. Watts, G.S., Oshiro, M.M., Junk, D.J., Wozniak, R.J., Watterson, S., Domann, F.E., Futscher, B.W. Neoplasia (2004)
- IFN-Stimulated transcription through a TBP-free acetyltransferase complex escapes viral shutoff. Paulson, M., Press, C., Smith, E., Tanese, N., Levy, D.E. Nat. Cell Biol. (2002)
- E4F1 Is an Atypical Ubiquitin Ligase that Modulates p53 Effector Functions Independently of Degradation. Le Cam, L., Linares, L.K., Paul, C., Julien, E., Lacroix, M., Hatchi, E., Triboulet, R., Bossis, G., Shmueli, A., Rodriguez, M.S., Coux, O., Sardet, C. Cell (2006)
- Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein. Seo, S.B., McNamara, P., Heo, S., Turner, A., Lane, W.S., Chakravarti, D. Cell (2001)
- Regulation of histone acetyltransferases p300 and PCAF by the bHLH protein twist and adenoviral oncoprotein E1A. Hamamori, Y., Sartorelli, V., Ogryzko, V., Puri, P.L., Wu, H.Y., Wang, J.Y., Nakatani, Y., Kedes, L. Cell (1999)
- A viral mechanism for inhibition of p300 and PCAF acetyltransferase activity. Chakravarti, D., Ogryzko, V., Kao, H.Y., Nash, A., Chen, H., Nakatani, Y., Evans, R.M. Cell (1999)
- Histone-like TAFs within the PCAF histone acetylase complex. Ogryzko, V.V., Kotani, T., Zhang, X., Schiltz, R.L., Howard, T., Yang, X.J., Howard, B.H., Qin, J., Nakatani, Y. Cell (1998)
- Chemohormonal therapy in advanced carcinoma of the breast: Cancer and Leukemia Group B protocol 8081. Perry, M.C., Kardinal, C.G., Korzun, A.H., Ginsberg, S.J., Raich, P.C., Holland, J.F., Ellison, R.R., Kopel, S., Schilling, A., Aisner, J. J. Clin. Oncol. (1987)
- A randomized multicenter trial of cyclophosphamide, Novantrone and 5-fluorouracil (CNF) versus cyclophosphamide, Adriamycin and 5-fluorouracil (CAF) in patients with metastatic breast cancer. Bennett, J.M., Byrne, P., Desai, A., White, C., DeConti, R., Vogel, C., Krementz, E., Muggia, F., Doroshow, J., Plotkin, D. Investigational new drugs. (1985)
- Adjuvant chemohormonal therapy with cyclophosphamide, doxorubicin and 5-fluorouracil (CAF) with or without medroxyprogesterone acetate for node-positive breast cancer patients. Hupperets, P.S., Wils, J., Volovics, L., Schouten, L., Fickers, M., Bron, H., Schouten, H.C., Jager, J., Smeets, J., de Jong, J. Ann. Oncol. (1993)
- The Eastern Cooperative Oncology Group experience with cyclophosphamide, adriamycin, and 5-fluorouracil (CAF) in patients with metastatic breast cancer. Falkson, G., Gelman, R.S., Tormey, D.C., Cummings, F.J., Carbone, P.P., Falkson, H.C. Cancer (1985)
- Differential acetylation of Tat coordinates its interaction with the co-activators cyclin T1 and PCAF. Brès, V., Tagami, H., Péloponèse, J.M., Loret, E., Jeang, K.T., Nakatani, Y., Emiliani, S., Benkirane, M., Kiernan, R.E. EMBO J. (2002)
- Direct p53 transcriptional repression: in vivo analysis of CCAAT-containing G2/M promoters. Imbriano, C., Gurtner, A., Cocchiarella, F., Di Agostino, S., Basile, V., Gostissa, M., Dobbelstein, M., Del Sal, G., Piaggio, G., Mantovani, R. Mol. Cell. Biol. (2005)
- p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage. Liu, L., Scolnick, D.M., Trievel, R.C., Zhang, H.B., Marmorstein, R., Halazonetis, T.D., Berger, S.L. Mol. Cell. Biol. (1999)
- Interaction of histone acetylases and deacetylases in vivo. Yamagoe, S., Kanno, T., Kanno, Y., Sasaki, S., Siegel, R.M., Lenardo, M.J., Humphrey, G., Wang, Y., Nakatani, Y., Howard, B.H., Ozato, K. Mol. Cell. Biol. (2003)
- The histone acetylase PCAF is a phorbol-ester-inducible coactivator of the IRF family that confers enhanced interferon responsiveness. Masumi, A., Wang, I.M., Lefebvre, B., Yang, X.J., Nakatani, Y., Ozato, K. Mol. Cell. Biol. (1999)
- MDM2 mediates p300/CREB-binding protein-associated factor ubiquitination and degradation. Jin, Y., Zeng, S.X., Lee, H., Lu, H. J. Biol. Chem. (2004)
- Site-specific acetylation of the fetal globin activator NF-E4 prevents its ubiquitination and regulates its interaction with the histone deacetylase, HDAC1. Zhao, Q., Cumming, H., Cerruti, L., Cunningham, J.M., Jane, S.M. J. Biol. Chem. (2004)
- Regulation of the homeodomain CCAAT displacement/cut protein function by histone acetyltransferases p300/CREB-binding protein (CBP)-associated factor and CBP. Li, S., Aufiero, B., Schiltz, R.L., Walsh, M.J. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Acetylation by PCAF enhances CIITA nuclear accumulation and transactivation of major histocompatibility complex class II genes. Spilianakis, C., Papamatheakis, J., Kretsovali, A. Mol. Cell. Biol. (2000)
- Fluorescence analysis of a dynamic loop in the PCAF/GCN5 histone acetyltransferase. Zheng, Y., Mamdani, F., Toptygin, D., Brand, L., Stivers, J.T., Cole, P.A. Biochemistry (2005)
- Application of a fluorescent histone acetyltransferase assay to probe the substrate specificity of the human p300/CBP-associated factor. Trievel, R.C., Li, F.Y., Marmorstein, R. Anal. Biochem. (2000)
- MDM2 inhibits PCAF (p300/CREB-binding protein-associated factor)-mediated p53 acetylation. Jin, Y., Zeng, S.X., Dai, M.S., Yang, X.J., Lu, H. J. Biol. Chem. (2002)
- Coactivator p300 acetylates the interferon regulatory factor-2 in U937 cells following phorbol ester treatment. Masumi, A., Ozato, K. J. Biol. Chem. (2001)
- Acetylation of interferon regulatory factor-7 by p300/CREB-binding protein (CBP)-associated factor (PCAF) impairs its DNA binding. Caillaud, A., Prakash, A., Smith, E., Masumi, A., Hovanessian, A.G., Levy, D.E., Marié, I. J. Biol. Chem. (2002)
- The histone acetyltransferase activity of PCAF cooperates with the brahma/SWI2-related protein BRG-1 in the activation of the enhancer A of the MHC class I promoter. Brockmann, D., Lehmkühler, O., Schmücker, U., Esche, H. Gene (2001)
- The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily. Vassilev, A., Yamauchi, J., Kotani, T., Prives, C., Avantaggiati, M.L., Qin, J., Nakatani, Y. Mol. Cell (1998)
- Regulation of transcription factor YY1 by acetylation and deacetylation. Yao, Y.L., Yang, W.M., Seto, E. Mol. Cell. Biol. (2001)
- Regulation of ERK1 gene expression by coactivator proteins. Chu, B.Y., Tran, K., Ku, T.K., Crowe, D.L. Biochem. J. (2005)
- Specific acetylation of chromosomal protein HMG-17 by PCAF alters its interaction with nucleosomes. Herrera, J.E., Sakaguchi, K., Bergel, M., Trieschmann, L., Nakatani, Y., Bustin, M. Mol. Cell. Biol. (1999)
- Mammalian GCN5 and P/CAF acetyltransferases have homologous amino-terminal domains important for recognition of nucleosomal substrates. Xu, W., Edmondson, D.G., Roth, S.Y. Mol. Cell. Biol. (1998)
- Androgen receptor acetylation governs trans activation and MEKK1-induced apoptosis without affecting in vitro sumoylation and trans-repression function. Fu, M., Wang, C., Wang, J., Zhang, X., Sakamaki, T., Yeung, Y.G., Chang, C., Hopp, T., Fuqua, S.A., Jaffray, E., Hay, R.T., Palvimo, J.J., Jänne, O.A., Pestell, R.G. Mol. Cell. Biol. (2002)
- Molecular interaction of retinoic acid receptors with coregulators PCAF and RIP140. Chen, Y., Hu, X., Wei, L.N. Mol. Cell. Endocrinol. (2004)
- Coactivators p300 and PCAF physically and functionally interact with the foamy viral trans-activator. Bannert, H., Muranyi, W., Ogryzko, V.V., Nakatani, Y., Flügel, R.M. BMC Mol. Biol. (2004)
- The diurnal rhythm of adrenocorticotropic hormone secretion in the assessment of the adequacy of replacement therapy in primary chronic adrenal failure. Fadeev, V.V., Gitel, E.P., Mel'nichenko, G.A. Neurosci. Behav. Physiol. (2001)
- Treatment of metastatic breast cancer in premenopausal women using CAF with or without oophorectomy: an Eastern Cooperative Oncology Group Study. Falkson, G., Gelman, R.S., Tormey, D.C., Falkson, C.I., Wolter, J.M., Cummings, F.J. J. Clin. Oncol. (1987)