Gene Review:
ARHGEF7 - Rho guanine nucleotide exchange factor...
Homo sapiens
Synonyms:
BETA-PIX, Beta-Pix, COOL-1, COOL1, DKFZp686C12170, ...
- Genomic structure of the human beta-PIX gene and its alteration in gastric cancer. Li, Z., Wang, Y., Song, J., Kataoka, H., Yoshii, S., Gao, C., Wang, Y., Zhou, J., Ota, S., Tanaka, M., Sugimura, H. Cancer Lett. (2002)
- Interaction between Nef and phosphatidylinositol-3-kinase leads to activation of p21-activated kinase and increased production of HIV. Linnemann, T., Zheng, Y.H., Mandic, R., Peterlin, B.M. Virology (2002)
- Hemoglobin Syracuse (alpha2beta2-143(H21)His leads to Pro), a new high-affinity variant detected by special electrophoretic methods. Observations on the auto-oxidation of normal and variant hemoglobins. Jensen, M., Oski, F.A., Nathan, D.G., Bunn, H.F. J. Clin. Invest. (1975)
- Tissue oxygenation and muscular substrate turnover in two subjects with high hemoglobin oxygen affinity. Wranne, B., Berlin, G., Jorfeldt, L., Lund, N. J. Clin. Invest. (1983)
- Oxygen delivery and consumption and P50 in patients with acute myocardial infarction. Yang, S.C., Puri, V.K., Raheja, R. Circulation (1986)
- Sequential implication of the mental retardation proteins ARHGEF6 and PAK3 in spine morphogenesis. Nod??-Langlois, R., Muller, D., Boda, B. J. Cell. Sci. (2006)
- Sensory gating deficits assessed by the P50 event-related potential in subjects with schizotypal personality disorder. Cadenhead, K.S., Light, G.A., Geyer, M.A., Braff, D.L. The American journal of psychiatry. (2000)
- Sensory gating deficit expressed by a disturbed suppression of the P50 event-related potential in patients with Alzheimer's disease. Jessen, F., Kucharski, C., Fries, T., Papassotiropoulos, A., Hoenig, K., Maier, W., Heun, R. The American journal of psychiatry. (2001)
- Diminished suppression of the P50 auditory evoked potential in bipolar disorder subjects with a history of psychosis. Olincy, A., Martin, L. The American journal of psychiatry. (2005)
- Sensory gating in chronic posttraumatic stress disorder: reduced auditory P50 suppression in combat veterans. Neylan, T.C., Fletcher, D.J., Lenoci, M., McCallin, K., Weiss, D.S., Schoenfeld, F.B., Marmar, C.R., Fein, G. Biol. Psychiatry (1999)
- Structure of the PI3K SH3 domain and analysis of the SH3 family. Koyama, S., Yu, H., Dalgarno, D.C., Shin, T.B., Zydowsky, L.D., Schreiber, S.L. Cell (1993)
- Smokers' polycythemia. Smith, J.R., Landaw, S.A. N. Engl. J. Med. (1978)
- Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase. Price, D.J., Grove, J.R., Calvo, V., Avruch, J., Bierer, B.E. Science (1992)
- Synthesis and evaluation of a prototypal artificial red cell. Hunt, C.A., Burnette, R.R., MacGregor, R.D., Strubbe, A.E., Lau, D.T., Taylor, N., Kiwada, H. Science (1985)
- Enzymatic function of hemoglobin as a nitrite reductase that produces NO under allosteric control. Huang, Z., Shiva, S., Kim-Shapiro, D.B., Patel, R.P., Ringwood, L.A., Irby, C.E., Huang, K.T., Ho, C., Hogg, N., Schechter, A.N., Gladwin, M.T. J. Clin. Invest. (2005)
- Effects of methylprednisolone on P50, 2,3 diphosphoglycerate and arteriovenous oxygen difference in acute myocardial infarction. Kalter, E.S., Henning, R.J., Thijs, L., Vincent, J.L., Becker, H., Carlson, R.W., Weil, M.H. Circulation (1980)
- Erythrocyte O2 transport and metabolism and effects of vitamin B6 therapy in type II diabetes mellitus. Solomon, L.R., Cohen, K. Diabetes (1989)
- Cocaine abusers have reduced auditory P50 amplitude and suppression compared to both normal controls and alcoholics. Fein, G., Biggins, C., MacKay, S. Biol. Psychiatry (1996)
- Activation of Epstein-Barr virus/C3d receptor (gp140, CR2, CD21) on human B lymphoma cell surface triggers Cbl tyrosine phosphorylation, its association with p85 subunit, Crk-L and Syk and its dissociation with Vav. Lottin-Divoux, S., Jean, D., Le Romancer, M., Frade, R. Cell. Signal. (2006)
- Tropisetron improves deficits in auditory P50 suppression in schizophrenia. Koike, K., Hashimoto, K., Takai, N., Shimizu, E., Komatsu, N., Watanabe, H., Nakazato, M., Okamura, N., Stevens, K.E., Freedman, R., Iyo, M. Schizophr. Res. (2005)
- Basic fibroblast growth factor stimulates activation of Rac1 through a p85 betaPIX phosphorylation-dependent pathway. Shin, E.Y., Woo, K.N., Lee, C.S., Koo, S.H., Kim, Y.G., Kim, W.J., Bae, C.D., Chang, S.I., Kim, E.G. J. Biol. Chem. (2004)
- A PI3K activity-independent function of p85 regulatory subunit in control of mammalian cytokinesis. Garc??a, Z., Silio, V., Marqu??s, M., Cort??s, I., Kumar, A., Hernandez, C., Checa, A.I., Serrano, A., Carrera, A.C. EMBO J. (2006)
- Phosphorylation of p85 beta PIX, a Rac/Cdc42-specific guanine nucleotide exchange factor, via the Ras/ERK/PAK2 pathway is required for basic fibroblast growth factor-induced neurite outgrowth. Shin, E.Y., Shin, K.S., Lee, C.S., Woo, K.N., Quan, S.H., Soung, N.K., Kim, Y.G., Cha, C.I., Kim, S.R., Park, D., Bokoch, G.M., Kim, E.G. J. Biol. Chem. (2002)
- GIT2 represses Crk- and Rac1-regulated cell spreading and Cdc42-mediated focal adhesion turnover. Frank, S.R., Adelstein, M.R., Hansen, S.H. EMBO J. (2006)
- Regulation of phosphatidylinositol 3-kinase activity and phosphatidylinositol 3,4,5-trisphosphate accumulation by neutrophil priming agents. Cadwallader, K.A., Condliffe, A.M., McGregor, A., Walker, T.R., White, J.F., Stephens, L.R., Chilvers, E.R. J. Immunol. (2002)
- Human SPA-1 gene product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2. Segregate expression profiles from a rap1GAP gene product. Kurachi, H., Wada, Y., Tsukamoto, N., Maeda, M., Kubota, H., Hattori, M., Iwai, K., Minato, N. J. Biol. Chem. (1997)
- A tyrosine kinase signaling pathway accounts for the majority of phosphatidylinositol 3,4,5-trisphosphate formation in chemoattractant-stimulated human neutrophils. Ptasznik, A., Prossnitz, E.R., Yoshikawa, D., Smrcka, A., Traynor-Kaplan, A.E., Bokoch, G.M. J. Biol. Chem. (1996)
- Deficiency of skeletal muscle succinate dehydrogenase and aconitase. Pathophysiology of exercise in a novel human muscle oxidative defect. Haller, R.G., Henriksson, K.G., Jorfeldt, L., Hultman, E., Wibom, R., Sahlin, K., Areskog, N.H., Gunder, M., Ayyad, K., Blomqvist, C.G. J. Clin. Invest. (1991)
- Erythrocyte metabolism in purine nucleoside phosphorylase deficiency after enzyme replacement therapy by infusion of erythrocytes. Staal, G.E., Stoop, J.W., Zegers, B.J., Siegenbeek van Heukelom, L.H., van der Vlist, M.J., Wadman, S.K., Martin, D.W. J. Clin. Invest. (1980)
- Tyrosine 785 is a major determinant of Trk--substrate interaction. Obermeier, A., Halfter, H., Wiesmüller, K.H., Jung, G., Schlessinger, J., Ullrich, A. EMBO J. (1993)
- An inherent role of microtubule network in the action of nuclear receptor. Manavathi, B., Acconcia, F., Rayala, S.K., Kumar, R. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activation. Bagrodia, S., Dérijard, B., Davis, R.J., Cerione, R.A. J. Biol. Chem. (1995)
- Interaction of alphaPIX (ARHGEF6) with beta-parvin (PARVB) suggests an involvement of alphaPIX in integrin-mediated signaling. Rosenberger, G., Jantke, I., Gal, A., Kutsche, K. Hum. Mol. Genet. (2003)
- Characterization of rhoGAP. A GTPase-activating protein for rho-related small GTPases. Lancaster, C.A., Taylor-Harris, P.M., Self, A.J., Brill, S., van Erp, H.E., Hall, A. J. Biol. Chem. (1994)
- A cascade involving p85, Cdc42 and septin 2 regulates cytokinesis. Silió, V., Marqués, M., Cortés, I., Zuluaga, S., Carrera, A.C. Biochem. Soc. Trans. (2007)
- Direct binding of p85 to sst2 somatostatin receptor reveals a novel mechanism for inhibiting PI3K pathway. Bousquet, C., Guillermet-Guibert, J., Saint-Laurent, N., Archer-Lahlou, E., Lopez, F., Fanjul, M., Ferrand, A., Fourmy, D., Pichereaux, C., Monsarrat, B., Pradayrol, L., Estève, J.P., Susini, C. EMBO J. (2006)
- Recombinant human sickle hemoglobin expressed in yeast. Martin de Llano, J.J., Schneewind, O., Stetler, G., Manning, J.M. Proc. Natl. Acad. Sci. U.S.A. (1993)
- Microinjection of the SH2 domain of the 85-kilodalton subunit of phosphatidylinositol 3-kinase inhibits insulin-induced DNA synthesis and c-fos expression. Jhun, B.H., Rose, D.W., Seely, B.L., Rameh, L., Cantley, L., Saltiel, A.R., Olefsky, J.M. Mol. Cell. Biol. (1994)
- Rearranged NFKB-2 genes in lymphoid neoplasms code for constitutively active nuclear transactivators. Chang, C.C., Zhang, J., Lombardi, L., Neri, A., Dalla-Favera, R. Mol. Cell. Biol. (1995)