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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review: 

ZNF259  -  zinc finger protein 259

Homo sapiens

Synonyms: ZPR1, Zinc finger protein 259, Zinc finger protein ZPR1
 
 
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High impact information on ZNF259

  • Disruption of the binding of ZPR1 to eEF-1alpha by mutational analysis resulted in an accumulation of cells in the G2/M phase of cell cycle and defective growth [1].
  • In the yeast Saccharomyces cerevisiae, genetic analysis demonstrated that ZPR1 is an essential gene [1].
  • Deletion analysis demonstrated that the NH2-terminal region of ZPR1 is required for normal growth and that the COOH-terminal region was essential for viability in S. cerevisiae [1].
  • We conclude that ZPR1 is essential for cell viability and that its interaction with eEF-1alpha contributes to normal cellular proliferation [1].
  • These changes in subnuclear architecture and cell cycle progression may be caused by transcriptional defects in ZPR1-deficient cells, including decreased histone gene expression [2].
 

Anatomical context of ZNF259

  • ZPR1 deficiency causes disruption of survival motor neurons and NPAT localization within the nucleus, blocks S phase progression, and arrests cells in both the G(1) and G(2) phases of the cell cycle [2].

References

  1. Interaction of ZPR1 with translation elongation factor-1alpha in proliferating cells. Gangwani, L., Mikrut, M., Galcheva-Gargova, Z., Davis, R.J. J. Cell Biol. (1998) [Pubmed]
  2. Deficiency of the Zinc Finger Protein ZPR1 Causes Defects in Transcription and Cell Cycle Progression. Gangwani, L. J. Biol. Chem. (2006) [Pubmed]
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