Gene Review:
vacA - vacuolating cytotoxin
Helicobacter pylori J99
Suerbaum,
Smith,
Bapumia,
Morelli,
Smith,
Kunstmann,
Dyrek,
Achtman,
Peek,
Wirth,
Moss,
Yang,
Abdalla,
Tham,
Zhang,
Tang,
Modlin,
Blaser,
Aydin,
Kaklikkaya,
Ozgur,
Cubukcu,
Kilic,
Tosun,
Erturk,
Gatti,
Módena,
Payão,
Smith,
Fukuhara,
Módena,
de Oliveira,
Brocchi,
Figueiredo,
Machado,
Pharoah,
Seruca,
Sousa,
Carvalho,
Capelinha,
Quint,
Caldas,
van Doorn,
Carneiro,
Sobrinho-Simões,
Letley,
Rhead,
Twells,
Dove,
Atherton,
Van Doorn,
Figueiredo,
Mégraud,
Pena,
Midolo,
Queiroz,
Carneiro,
Vanderborght,
Pegado,
Sanna,
De Boer,
Schneeberger,
Correa,
Ng,
Atherton,
Blaser,
Quint,
Ogura,
Maeda,
Nakao,
Watanabe,
Tada,
Kyutoku,
Yoshida,
Shiratori,
Omata,
van Doorn,
Glupczynski,
Kusters,
Mégraud,
Midolo,
Maggi-Solcà,
Queiroz,
Nouhan,
Stet,
Quint,
- Distribution of vacA alleles and cagA status of Helicobacter pylori in peptic ulcer disease and non-ulcer dyspepsia. Aydin, F., Kaklikkaya, N., Ozgur, O., Cubukcu, K., Kilic, A.O., Tosun, I., Erturk, M. Clin. Microbiol. Infect. (2004)
- Helicobacter pylori BabA expression, gastric mucosal injury, and clinical outcome. Fujimoto, S., Olaniyi Ojo, O., Arnqvist, A., Wu, J.Y., Odenbreit, S., Haas, R., Graham, D.Y., Yamaoka, Y. Clin. Gastroenterol. Hepatol. (2007)
- Virulence factors of Helicobacter pylori responsible for gastric diseases in Mongolian gerbil. Ogura, K., Maeda, S., Nakao, M., Watanabe, T., Tada, M., Kyutoku, T., Yoshida, H., Shiratori, Y., Omata, M. J. Exp. Med. (2000)
- Mice deficient in protein tyrosine phosphatase receptor type Z are resistant to gastric ulcer induction by VacA of Helicobacter pylori. Fujikawa, A., Shirasaka, D., Yamamoto, S., Ota, H., Yahiro, K., Fukada, M., Shintani, T., Wada, A., Aoyama, N., Hirayama, T., Fukamachi, H., Noda, M. Nat. Genet. (2003)
- Helicobacter pylori and interleukin 1 genotyping: an opportunity to identify high-risk individuals for gastric carcinoma. Figueiredo, C., Machado, J.C., Pharoah, P., Seruca, R., Sousa, S., Carvalho, R., Capelinha, A.F., Quint, W., Caldas, C., van Doorn, L.J., Carneiro, F., Sobrinho-Simões, M. J. Natl. Cancer Inst. (2002)
- Geographic distribution of vacA allelic types of Helicobacter pylori. Van Doorn, L.J., Figueiredo, C., Mégraud, F., Pena, S., Midolo, P., Queiroz, D.M., Carneiro, F., Vanderborght, B., Pegado, M.D., Sanna, R., De Boer, W., Schneeberger, P.M., Correa, P., Ng, E.K., Atherton, J., Blaser, M.J., Quint, W.G. Gastroenterology (1999)
- Introduction of unmarked mutations in the Helicobacter pylori vacA gene with a sucrose sensitivity marker. Copass, M., Grandi, G., Rappuoli, R. Infect. Immun. (1997)
- Evaluation of clarithromycin resistance and cagA and vacA genotyping of Helicobacter pylori strains from the west of Ireland using line probe assays. Ryan, K.A., van Doorn, L.J., Moran, A.P., Glennon, M., Smith, T., Maher, M. J. Clin. Microbiol. (2001)
- Helicobacter pylori Vacuolating Cytotoxin Induces Activation of the Proapoptotic Proteins Bax and Bak, Leading to Cytochrome c Release and Cell Death, Independent of Vacuolation. Yamasaki, E., Wada, A., Kumatori, A., Nakagawa, I., Funao, J., Nakayama, M., Hisatsune, J., Kimura, M., Moss, J., Hirayama, T. J. Biol. Chem. (2006)
- Glycosylphosphatidylinositol-anchored proteins and actin cytoskeleton modulate chloride transport by channels formed by the Helicobacter pylori vacuolating cytotoxin VacA in HeLa cells. Gauthier, N.C., Ricci, V., Gounon, P., Doye, A., Tauc, M., Poujeol, P., Boquet, P. J. Biol. Chem. (2004)
- Prevalence of Helicobacter pylori vacA, cagA, cagE, iceA, babA2 Genotypes and Correlation with Clinical Outcome in Turkish Patients with Dyspepsia. Erzin, Y., Koksal, V., Altun, S., Dobrucali, A., Aslan, M., Erdamar, S., Dirican, A., Kocazeybek, B. Helicobacter (2006)
- Prevalence of Helicobacter pylori cagA, iceA and babA2 alleles in Brazilian patients with upper gastrointestinal diseases. Gatti, L.L., Módena, J.L., Payão, S.L., Smith, M.d.e. .A., Fukuhara, Y., Módena, J.L., de Oliveira, R.B., Brocchi, M. Acta Trop. (2006)
- Helicobacter pylori cagA+ strains and dissociation of gastric epithelial cell proliferation from apoptosis. Peek, R.M., Moss, S.F., Tham, K.T., Pérez-Pérez, G.I., Wang, S., Miller, G.G., Atherton, J.C., Holt, P.R., Blaser, M.J. J. Natl. Cancer Inst. (1997)
- Helicobacter pylori binds von Willebrand factor and interacts with GPIb to induce platelet aggregation. Byrne, M.F., Kerrigan, S.W., Corcoran, P.A., Atherton, J.C., Murray, F.E., Fitzgerald, D.J., Cox, D.M. Gastroenterology (2003)
- Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration. Atherton, J.C., Cao, P., Peek, R.M., Tummuru, M.K., Blaser, M.J., Cover, T.L. J. Biol. Chem. (1995)
- Helicobacter pylori alters gastric epithelial cell cycle events and gastrin secretion in Mongolian gerbils. Peek, R.M., Wirth, H.P., Moss, S.F., Yang, M., Abdalla, A.M., Tham, K.T., Zhang, T., Tang, L.H., Modlin, I.M., Blaser, M.J. Gastroenterology (2000)
- Clinical and pathological importance of heterogeneity in vacA, the vacuolating cytotoxin gene of Helicobacter pylori. Atherton, J.C., Peek, R.M., Tham, K.T., Cover, T.L., Blaser, M.J. Gastroenterology (1997)
- The m2 form of the Helicobacter pylori cytotoxin has cell type-specific vacuolating activity. Pagliaccia, C., de Bernard, M., Lupetti, P., Ji, X., Burroni, D., Cover, T.L., Papini, E., Rappuoli, R., Telford, J.L., Reyrat, J.M. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Determinants of non-toxicity in the gastric pathogen Helicobacter pylori. Letley, D.P., Rhead, J.L., Twells, R.J., Dove, B., Atherton, J.C. J. Biol. Chem. (2003)
- Essential role of a GXXXG motif for membrane channel formation by Helicobacter pylori vacuolating toxin. McClain, M.S., Iwamoto, H., Cao, P., Vinion-Dubiel, A.D., Li, Y., Szabo, G., Shao, Z., Cover, T.L. J. Biol. Chem. (2003)
- Accurate prediction of macrolide resistance in Helicobacter pylori by a PCR line probe assay for detection of mutations in the 23S rRNA gene: multicenter validation study. van Doorn, L.J., Glupczynski, Y., Kusters, J.G., Mégraud, F., Midolo, P., Maggi-Solcà, N., Queiroz, D.M., Nouhan, N., Stet, E., Quint, W.G. Antimicrob. Agents Chemother. (2001)
- Pathological significance and molecular characterization of the vacuolating toxin gene of Helicobacter pylori. Phadnis, S.H., Ilver, D., Janzon, L., Normark, S., Westblom, T.U. Infect. Immun. (1994)
- Free recombination within Helicobacter pylori. Suerbaum, S., Smith, J.M., Bapumia, K., Morelli, G., Smith, N.H., Kunstmann, E., Dyrek, I., Achtman, M. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Analysis of genetic diversity in cytotoxin-producing and non-cytotoxin-producing Helicobacter pylori strains. Garner, J.A., Cover, T.L. J. Infect. Dis. (1995)
- Quantitative evaluation of inflammatory and immune responses in the early stages of chronic Helicobacter pylori infection. Straubinger, R.K., Greiter, A., McDonough, S.P., Gerold, A., Scanziani, E., Soldati, S., Dailidiene, D., Dailide, G., Berg, D.E., Simpson, K.W. Infect. Immun. (2003)
- Divergence of genetic sequences for the vacuolating cytotoxin among Helicobacter pylori strains. Cover, T.L., Tummuru, M.K., Cao, P., Thompson, S.A., Blaser, M.J. J. Biol. Chem. (1994)
- Association of peptic ulcer with increased expression of Lewis antigens but not cagA, iceA, and vacA in Helicobacter pylori isolates in an Asian population. Zheng, P.Y., Hua, J., Yeoh, K.G., Ho, B. Gut (2000)
- Genetic analysis of the Helicobacter pylori vacuolating cytotoxin: structural similarities with the IgA protease type of exported protein. Schmitt, W., Haas, R. Mol. Microbiol. (1994)
- Importance of Helicobacter pylori cagA and vacA status for the efficacy of antibiotic treatment. van Doorn, L.J., Schneeberger, P.M., Nouhan, N., Plaisier, A.P., Quint, W.G., de Boer, W.A. Gut (2000)