Gene Review:
BTRC - beta-transducin repeat containing E3...
Homo sapiens
Synonyms:
BETA-TRCP, BTRCP, E3RSIkappaB, Epididymis tissue protein Li 2a, F-box and WD repeats protein beta-TrCP, ...
Mercurio,
Ogata,
Omata,
Pierce,
Osada,
Podust,
Watanabe,
Coggins,
Arai,
Brownell,
Kikugawa,
Ruzicka,
Arai,
Taniguchi,
Wolter,
Shiina,
Luo,
Nishihara,
Pietsch,
Watanabe,
Deshaies,
Read,
Mantovani,
Knobbe,
Hayakawa,
Parent,
Chau,
Gladysheva,
Hunter,
Hottelet,
Reifenberger,
Karin,
Kitagawa,
Kumagai,
Suzuki,
Kim,
Chiba,
Watanabe,
Iwasaki,
Ben-Neriah,
Tanaka,
Reifenberger,
Sakamoto,
Hunter,
Schulte,
Kitagawa,
Osada,
Blaschke,
Tanigami,
Miyazawa,
Crews,
Ikenoue,
Fujiwara,
Palombella,
Banks,
- Molecular genetic analysis of malignant melanomas for aberrations of the WNT signaling pathway genes CTNNB1, APC, ICAT and BTRC. Reifenberger, J., Knobbe, C.B., Wolter, M., Blaschke, B., Schulte, K.W., Pietsch, T., Ruzicka, T., Reifenberger, G. Int. J. Cancer (2002)
- Associations among beta-TrCP, an E3 ubiquitin ligase receptor, beta-catenin, and NF-kappaB in colorectal cancer. Ougolkov, A., Zhang, B., Yamashita, K., Bilim, V., Mai, M., Fuchs, S.Y., Minamoto, T. J. Natl. Cancer Inst. (2004)
- Elevated expression of Wnt antagonists is a common event in hepatoblastomas. Koch, A., Waha, A., Hartmann, W., Hrychyk, A., Schüller, U., Waha, A., Wharton, K.A., Fuchs, S.Y., von Schweinitz, D., Pietsch, T. Clin. Cancer Res. (2005)
- Acute myelogenous leukemia-derived SMAD4 mutations target the protein to ubiquitin-proteasome degradation. Yang, L., Wang, N., Tang, Y., Cao, X., Wan, M. Hum. Mutat. (2006)
- beta-Trcp mediates ubiquitination and degradation of the erythropoietin receptor and controls cell proliferation. Meyer, L., Deau, B., Forejtníková, H., Duménil, D., Margottin-Goguet, F., Lacombe, C., Mayeux, P., Verdier, F. Blood (2007)
- Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. Karin, M., Ben-Neriah, Y. Annu. Rev. Immunol. (2000)
- SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase. Jin, J., Shirogane, T., Xu, L., Nalepa, G., Qin, J., Elledge, S.J., Harper, J.W. Genes Dev. (2003)
- SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response. Peschiaroli, A., Dorrello, N.V., Guardavaccaro, D., Venere, M., Halazonetis, T., Sherman, N.E., Pagano, M. Mol. Cell (2006)
- The BTRC gene, encoding a human F-box/WD40-repeat protein, maps to chromosome 10q24-q25. Fujiwara, T., Suzuki, M., Tanigami, A., Ikenoue, T., Omata, M., Chiba, T., Tanaka, K. Genomics (1999)
- beta-TrCP mediates the signal-induced ubiquitination of IkappaBbeta. Wu, C., Ghosh, S. J. Biol. Chem. (1999)
- STD and TRNOESY NMR studies on the conformation of the oncogenic protein beta-catenin containing the phosphorylated motif DpSGXXpS bound to the beta-TrCP protein. Megy, S., Bertho, G., Gharbi-Benarous, J., Evrard-Todeschi, N., Coadou, G., Ségéral, E., Iehle, C., Quéméneur, E., Benarous, R., Girault, J.P. J. Biol. Chem. (2005)
- Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage. Busino, L., Donzelli, M., Chiesa, M., Guardavaccaro, D., Ganoth, D., Dorrello, N.V., Hershko, A., Pagano, M., Draetta, G.F. Nature (2003)
- M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP. Watanabe, N., Arai, H., Nishihara, Y., Taniguchi, M., Watanabe, N., Hunter, T., Osada, H. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Regulation of the discs large tumor suppressor by a phosphorylation-dependent interaction with the beta-TrCP ubiquitin ligase receptor. Mantovani, F., Banks, L. J. Biol. Chem. (2003)
- Oncogenic BRAF regulates beta-Trcp expression and NF-kappaB activity in human melanoma cells. Liu, J., Suresh Kumar, K.G., Yu, D., Molton, S.A., McMahon, M., Herlyn, M., Thomas-Tikhonenko, A., Fuchs, S.Y. Oncogene (2007)
- Absence of detectable alterations in the putative tumor suppressor gene BTRC in cerebellar medulloblastomas and cutaneous basal cell carcinomas. Wolter, M., Scharwächter, C., Reifenberger, J., Koch, A., Pietsch, T., Reifenberger, G. Acta Neuropathol. (2003)
- Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase. Wu, G., Xu, G., Schulman, B.A., Jeffrey, P.D., Harper, J.W., Pavletich, N.P. Mol. Cell (2003)
- The FWD1/beta-TrCP-mediated degradation pathway establishes a 'turning off switch' of a Cdc42 guanine nucleotide exchange factor, FGD1. Hayakawa, M., Kitagawa, H., Miyazawa, K., Kitagawa, M., Kikugawa, K. Genes Cells (2005)
- ATF4 degradation relies on a phosphorylation-dependent interaction with the SCF(betaTrCP) ubiquitin ligase. Lassot, I., Ségéral, E., Berlioz-Torrent, C., Durand, H., Groussin, L., Hai, T., Benarous, R., Margottin-Goguet, F. Mol. Cell. Biol. (2001)
- Protacs: chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation. Sakamoto, K.M., Kim, K.B., Kumagai, A., Mercurio, F., Crews, C.M., Deshaies, R.J. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Targeting beta-transducin repeat-containing protein E3 ubiquitin ligase augments the effects of antitumor drugs on breast cancer cells. Tang, W., Li, Y., Yu, D., Thomas-Tikhonenko, A., Spiegelman, V.S., Fuchs, S.Y. Cancer Res. (2005)
- Differential interaction of plakoglobin and beta-catenin with the ubiquitin-proteasome system. Sadot, E., Simcha, I., Iwai, K., Ciechanover, A., Geiger, B., Ben-Ze'ev, A. Oncogene (2000)
- p300 modulates ATF4 stability and transcriptional activity independently of its acetyltransferase domain. Lassot, I., Estrabaud, E., Emiliani, S., Benkirane, M., Benarous, R., Margottin-Goguet, F. J. Biol. Chem. (2005)
- Smad4 protein stability is regulated by ubiquitin ligase SCF beta-TrCP1. Wan, M., Tang, Y., Tytler, E.M., Lu, C., Jin, B., Vickers, S.M., Yang, L., Shi, X., Cao, X. J. Biol. Chem. (2004)
- Cyclin-dependent kinase (CDK) phosphorylation destabilizes somatic Wee1 via multiple pathways. Watanabe, N., Arai, H., Iwasaki, J., Shiina, M., Ogata, K., Hunter, T., Osada, H. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses. Matsuzawa, S.I., Reed, J.C. Mol. Cell (2001)
- Inducible degradation of IkappaBalpha by the proteasome requires interaction with the F-box protein h-betaTrCP. Kroll, M., Margottin, F., Kohl, A., Renard, P., Durand, H., Concordet, J.P., Bachelerie, F., Arenzana-Seisdedos, F., Benarous, R. J. Biol. Chem. (1999)
- A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif. Margottin, F., Bour, S.P., Durand, H., Selig, L., Benichou, S., Richard, V., Thomas, D., Strebel, K., Benarous, R. Mol. Cell (1998)
- Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha. Read, M.A., Brownell, J.E., Gladysheva, T.B., Hottelet, M., Parent, L.A., Coggins, M.B., Pierce, J.W., Podust, V.N., Luo, R.S., Chau, V., Palombella, V.J. Mol. Cell. Biol. (2000)
- Split-hand/split-foot malformation 3 (SHFM3) at 10q24, development of rapid diagnostic methods and gene expression from the region. Lyle, R., Radhakrishna, U., Blouin, J.L., Gagos, S., Everman, D.B., Gehrig, C., Delozier-Blanchet, C., Solanki, J.V., Patel, U.C., Nath, S.K., Gurrieri, F., Neri, G., Schwartz, C.E., Antonarakis, S.E. Am. J. Med. Genet. A (2006)