Gene Review:
SOCS3 - suppressor of cytokine signaling 3
Homo sapiens
Synonyms:
ATOD4, CIS-3, CIS3, Cish3, Cytokine-inducible SH2 protein 3, ...
Kietz,
Sprigg,
McManus,
Trzeciak,
Willson,
Nicola,
Leong,
Scapini,
Vollebregt,
Ballesteros,
Babon,
Hilton,
Leung,
Bovolenta,
Mielke,
Nicholson,
Ho,
Evans,
Leers,
Cassatella,
Calzetti,
Gasperini,
Yao,
Baca,
Sjogren,
Stoikos,
Matthews,
Salamonsen,
Egwuagu,
Suzuki,
Norton,
Gustafsson,
Mahdi,
Marchi,
Doyle,
Watts,
Suzuki,
Dimitriadis,
DeSouza,
Low,
Lohani,
Tan,
Liu,
Almlöf,
Ross,
Yoshimura,
Yu,
- Impaired IFN-gamma-dependent inflammatory responses in human keratinocytes overexpressing the suppressor of cytokine signaling 1. Federici, M., Giustizieri, M.L., Scarponi, C., Girolomoni, G., Albanesi, C. J. Immunol. (2002)
- Expression of SOCS1 and SOCS3 genes is differentially regulated in breast cancer cells in response to proinflammatory cytokine and growth factor signals. Evans, M.K., Yu, C.R., Lohani, A., Mahdi, R.M., Liu, X., Trzeciak, A.R., Egwuagu, C.E. Oncogene (2007)
- Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway. Yokota, S., Yokosawa, N., Okabayashi, T., Suzutani, T., Miura, S., Jimbow, K., Fujii, N. J. Virol. (2004)
- Methylation status of the SOCS3 gene in human malignant melanomas. Tokita, T., Maesawa, C., Kimura, T., Kotani, K., Takahashi, K., Akasaka, T., Masuda, T. Int. J. Oncol. (2007)
- A proinflammatory cytokine response is present in the fetal placental vasculature in placental insufficiency. Wang, X., Athayde, N., Trudinger, B. Am. J. Obstet. Gynecol. (2003)
- Photoperiodic regulation of leptin sensitivity in the Siberian hamster, Phodopus sungorus, is reflected in arcuate nucleus SOCS-3 (suppressor of cytokine signaling) gene expression. Tups, A., Ellis, C., Moar, K.M., Logie, T.J., Adam, C.L., Mercer, J.G., Klingenspor, M. Endocrinology (2004)
- The classification of multiple somatoform symptoms. Rief, W., Heuser, J., Mayrhuber, E., Stelzer, I., Hiller, W., Fichter, M.M. J. Nerv. Ment. Dis. (1996)
- Acute effects of growth hormone in alcohol-fed rats. Lang, C.H., Liu, X., Nystrom, G., Wu, D., Cooney, R.N., Frost, R.A. Alcohol Alcohol. (2000)
- Suppressors of cytokine signaling and immunity. Kubo, M., Hanada, T., Yoshimura, A. Nat. Immunol. (2003)
- The structure of SOCS3 reveals the basis of the extended SH2 domain function and identifies an unstructured insertion that regulates stability. Babon, J.J., McManus, E.J., Yao, S., DeSouza, D.P., Mielke, L.A., Sprigg, N.S., Willson, T.A., Hilton, D.J., Nicola, N.A., Baca, M., Nicholson, S.E., Norton, R.S. Mol. Cell (2006)
- Molecular and anatomical determinants of central leptin resistance. Münzberg, H., Myers, M.G. Nat. Neurosci. (2005)
- Functional inactivation of CXC chemokine receptor 4-mediated responses through SOCS3 up-regulation. Soriano, S.F., Hernanz-Falcón, P., Rodríguez-Frade, J.M., De Ana, A.M., Garzón, R., Carvalho-Pinto, C., Vila-Coro, A.J., Zaballos, A., Balomenos, D., Martínez-A, C., Mellado, M. J. Exp. Med. (2002)
- Estrogen receptor-alpha regulates SOCS-3 expression in human breast cancer cells. Matthews, J., Almlöf, T., Kietz, S., Leers, J., Gustafsson, J.A. Biochem. Biophys. Res. Commun. (2005)
- Polycythemia vera and its molecular basis: an update. Chen, G., Prchal, J.T. Best practice & research. Clinical haematology. (2006)
- Ubiquitous activation of Ras and Jak/Stat pathways in human HCC. Calvisi, D.F., Ladu, S., Gorden, A., Farina, M., Conner, E.A., Lee, J.S., Factor, V.M., Thorgeirsson, S.S. Gastroenterology (2006)
- Interleukin-10 (IL-10) selectively enhances CIS3/SOCS3 mRNA expression in human neutrophils: evidence for an IL-10-induced pathway that is independent of STAT protein activation. Cassatella, M.A., Gasperini, S., Bovolenta, C., Calzetti, F., Vollebregt, M., Scapini, P., Marchi, M., Suzuki, R., Suzuki, A., Yoshimura, A. Blood (1999)
- Tyrosine phosphorylation disrupts elongin interaction and accelerates SOCS3 degradation. Haan, S., Ferguson, P., Sommer, U., Hiremath, M., McVicar, D.W., Heinrich, P.C., Johnston, J.A., Cacalano, N.A. J. Biol. Chem. (2003)
- The MKK6/p38 mitogen-activated protein kinase pathway is capable of inducing SOCS3 gene expression and inhibits IL-6-induced transcription. Bode, J.G., Ludwig, S., Freitas, C.A., Schaper, F., Ruhl, M., Melmed, S., Heinrich, P.C., Häussinger, D. Biol. Chem. (2001)
- Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 confers efficient viral replication. Yokota, S., Yokosawa, N., Okabayashi, T., Suzutani, T., Fujii, N. Virology (2005)
- Vanadate enhances leptin-induced activation of JAK/STAT pathway in CHO cells. Kita, A., Uotani, S., Kuwahara, H., Takahashi, R., Oshima, K., Yamasaki, H., Mizuguchi, H., Hayakawa, T., Nagayama, Y., Yamaguchi, Y., Eguchi, K. Biochem. Biophys. Res. Commun. (2003)
- Sp3 is involved in the regulation of SOCS3 gene expression. Ehlting, C., Häussinger, D., Bode, J.G. Biochem. J. (2005)
- Methylation silencing of SOCS-3 promotes cell growth and migration by enhancing JAK/STAT and FAK signalings in human hepatocellular carcinoma. Niwa, Y., Kanda, H., Shikauchi, Y., Saiura, A., Matsubara, K., Kitagawa, T., Yamamoto, J., Kubo, T., Yoshikawa, H. Oncogene (2005)
- Probiotics and commensals reverse TNF-alpha- and IFN-gamma-induced dysfunction in human intestinal epithelial cells. Resta-Lenert, S., Barrett, K.E. Gastroenterology (2006)
- Interleukin 11 signaling components signal transducer and activator of transcription 3 (STAT3) and suppressor of cytokine signaling 3 (SOCS3) regulate human endometrial stromal cell differentiation. Dimitriadis, E., Stoikos, C., Tan, Y.L., Salamonsen, L.A. Endocrinology (2006)
- Cytokine-inducible SH2-containing protein suppresses PRL signaling by binding the PRL receptor. Dif, F., Saunier, E., Demeneix, B., Kelly, P.A., Edery, M. Endocrinology (2001)
- Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain. Sasaki, A., Yasukawa, H., Suzuki, A., Kamizono, S., Syoda, T., Kinjyo, I., Sasaki, M., Johnston, J.A., Yoshimura, A. Genes Cells (1999)
- Suppressor of cytokine signaling (SOCS)-3 protein interacts with the insulin-like growth factor-I receptor. Dey, B.R., Furlanetto, R.W., Nissley, P. Biochem. Biophys. Res. Commun. (2000)
- A new high affinity binding site for suppressor of cytokine signaling-3 on the erythropoietin receptor. Hörtner, M., Nielsch, U., Mayr, L.M., Heinrich, P.C., Haan, S. Eur. J. Biochem. (2002)
- IL-6 signaling via the STAT3/SOCS3 pathway: Functional Analysis of the Conserved STAT3 N-domain. Zhang, L., Badgwell, D.B., Bevers, J.J., Schlessinger, K., Murray, P.J., Levy, D.E., Watowich, S.S. Mol. Cell. Biochem. (2006)
- Interleukin-22 activates STAT3 and induces IL-10 by colon epithelial cells. Nagalakshmi, M.L., Rascle, A., Zurawski, S., Menon, S., de Waal Malefyt, R. Int. Immunopharmacol. (2004)
- Distinct activities of suppressor of cytokine signaling (SOCS) proteins and involvement of the SOCS box in controlling G-CSF signaling. van de Geijn, G.J., Gits, J., Touw, I.P. J. Leukoc. Biol. (2004)
- Regulation of suppressor of cytokine signaling 3 (SOCS3) mRNA stability by TNF-alpha involves activation of the MKK6/p38MAPK/MK2 cascade. Ehlting, C., Lai, W.S., Schaper, F., Brenndörfer, E.D., Matthes, R.J., Heinrich, P.C., Ludwig, S., Blackshear, P.J., Gaestel, M., Häussinger, D., Bode, J.G. J. Immunol. (2007)
- SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer. He, B., You, L., Uematsu, K., Zang, K., Xu, Z., Lee, A.Y., Costello, J.F., McCormick, F., Jablons, D.M. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2. Leung, K.C., Doyle, N., Ballesteros, M., Sjogren, K., Watts, C.K., Low, T.H., Leong, G.M., Ross, R.J., Ho, K.K. Proc. Natl. Acad. Sci. U.S.A. (2003)
- The suppressor of cytokine signaling (SOCS) 1 and SOCS3 but not SOCS2 proteins inhibit interferon-mediated antiviral and antiproliferative activities. Song, M.M., Shuai, K. J. Biol. Chem. (1998)
- Deletion of the SOCS3 gene in liver parenchymal cells promotes hepatitis-induced hepatocarcinogenesis. Ogata, H., Kobayashi, T., Chinen, T., Takaki, H., Sanada, T., Minoda, Y., Koga, K., Takaesu, G., Maehara, Y., Iida, M., Yoshimura, A. Gastroenterology (2006)
- STAT3 activation via interleukin 6 trans-signalling contributes to ileitis in SAMP1/Yit mice. Mitsuyama, K., Matsumoto, S., Rose-John, S., Suzuki, A., Hara, T., Tomiyasu, N., Handa, K., Tsuruta, O., Funabashi, H., Scheller, J., Toyonaga, A., Sata, M. Gut (2006)
- SOCS1 and SOCS3 are targeted by hepatitis C virus core/gC1qR ligation to inhibit T-cell function. Yao, Z.Q., Waggoner, S.N., Cruise, M.W., Hall, C., Xie, X., Oldach, D.W., Hahn, Y.S. J. Virol. (2005)
- Suppressor of cytokine signaling 3 expression in anaplastic large cell lymphoma. Cho-Vega, J.H., Rassidakis, G.Z., Amin, H.M., Tsioli, P., Spurgers, K., Remache, Y.K., Vega, F., Goy, A.H., Gilles, F., Medeiros, L.J. Leukemia (2004)