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Gene Review

oxyR  -  LysR family transcriptional regulator

Mycobacterium leprae TN

 
 
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Disease relevance of oxyR

  • The corresponding region carrying these genes in Mycobacterium leprae, an organism not sensitive to isoniazid, has a complete oxyR gene divergently transcribed from ahpC [1].
  • The binding site for OxyR overlapped P1oxyR, reminiscent of the autoregulatory loops controlling expression of oxyR in enteric bacteria and characteristic of the LysR superfamily in general [2].
  • Transcription of plasmid-borne M. leprae oxyR and ahpC was investigated in M. smegmatis and M. bovis BCG by S1 nuclease protection and transcriptional fusion analyses [2].
 

High impact information on oxyR

  • Purified mycobacterial OxyR was found to bind to the oxyR-ahpC promoter region from M. marinum and additional mycobacterial species [3].

References

  1. Mycobacterium tuberculosis is a natural mutant with an inactivated oxidative-stress regulatory gene: implications for sensitivity to isoniazid. Deretic, V., Philipp, W., Dhandayuthapani, S., Mudd, M.H., Curcic, R., Garbe, T., Heym, B., Via, L.E., Cole, S.T. Mol. Microbiol. (1995) [Pubmed]
  2. Interactions of OxyR with the promoter region of the oxyR and ahpC genes from Mycobacterium leprae and Mycobacterium tuberculosis. Dhandayuthapani, S., Mudd, M., Deretic, V. J. Bacteriol. (1997) [Pubmed]
  3. Oxidative stress response and characterization of the oxyR-ahpC and furA-katG loci in Mycobacterium marinum. Pagán-Ramos, E., Song, J., McFalone, M., Mudd, M.H., Deretic, V. J. Bacteriol. (1998) [Pubmed]
 
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