The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

DNAJA3  -  DnaJ (Hsp40) homolog, subfamily A, member 3

Homo sapiens

Synonyms: DnaJ homolog subfamily A member 3, mitochondrial, DnaJ protein Tid-1, HCA57, Hepatocellular carcinoma-associated antigen 57, TID1, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of DNAJA3

 

High impact information on DNAJA3

  • The human DnaJ protein, hTid-1, enhances binding of a multimer of the herpes simplex virus type 1 UL9 protein to oris, an origin of viral DNA replication [5].
  • Hence, we propose that TID1 gene products act to positively and negatively modulate apoptotic signal transduction or effector structures within the mitochondrial matrix [6].
  • Morphological changes consistent with apoptosis and cell death were evident 48 h after Ad.EGFP-hTid-1 transduction [1].
  • Collectively, the data suggest that hTid-1 represses the activity of NF-kappaB through physical and functional interactions with the IKK complex and IkappaB and, in doing so, it modulates cell growth and death [1].
  • Tid1 removal in these cells led to massive cell death [7].
 

Biological context of DNAJA3

  • Here we report the cloning and characterization of the genomic structure of the human TID1 gene (hTID1), which is located on chromosome 16p13.3. hTID1 is approximately 34 kb and is composed of 12 exons [8].
  • Subsequently, we found that abrogating the nuclear factor kappaB binding site in the IL-8 promoter completely blocked the Tid1 depletion-induced IL-8 expression in the breast cancer cells [2].
  • The human tumorous imaginal disc 1 (TID1) proteins including TID1(L) and TID1(S), members of the DnaJ domain protein family, are involved in multiple intracellular signaling pathways such as apoptosis induction, cell proliferation, and survival [9].
  • Here, we show that cells essentially lacking expression of hTID1 proteins are protected from cell death in response to multiple stimuli, including cisplatin, tumor necrosis factor alpha/cycloheximide and mitomycin C [10].
  • To elucidate the physiological function of hTID1, we depleted hTID1 proteins using the technique of RNA interference (RNAi) [10].
 

Anatomical context of DNAJA3

  • Consistently knockdown of endogenous TID1, mediated with specific short hairpin RNA, significantly reduced NGF-induced neurite growth in nnr5-TrkA cells [9].
  • Human T cell leukemia virus type 1 Tax associates with a molecular chaperone complex containing hTid-1 and Hsp70 [4].
  • Nonetheless, Tid1-deficient blastocysts were viable, hatched, formed an inner cell mass and trophectoderm, and implanted (E4.5), suggesting that the homozygous mutant embryos die between E4.5 and E7 [7].
  • 5. To assess the function of Tid1 in embryonic cells, mouse embryonic fibroblasts with the homologous Tid1 floxed allele were produced [7].
 

Associations of DNAJA3 with chemical compounds

  • Human tumorous imaginal disc 1 (TID1) associates with Trk receptor tyrosine kinases and regulates neurite outgrowth in nnr5-TrkA cells [9].
  • Moreover, in a sucrose gradient, the precursor form of hTid1 co-sedimented with capsid-like particles composed of the full-length core protein [11].
 

Physical interactions of DNAJA3

  • We further showed that hTid-1 interacts with the human interferon-gamma (Hu-IFN-gamma) receptor subunit IFN-gamma R2 [12].
 

Regulatory relationships of DNAJA3

  • Tid1 negatively regulates the migratory potential of cancer cells by inhibiting the production of interleukin-8 [2].
 

Other interactions of DNAJA3

  • The interaction between endogenous hTid-1 and Jak2 was shown in HEp2 cells [12].
  • Moreover, the cochaperonic and regulatory functions of Tid1 on HSP70 most likely play an essential role in this antitumor function of Tid1 in carcinoma cells [13].
  • Unlike the general perception of the role of the cellular chaperone proteins in assisting viral protein folding and thus enhancing virus replication, ectopic expression of Hdj1 and hTid1 suppressed replication of HBV in transfected human hepatoma cells [11].
  • For colorectal carcinomas as well as colonic polyps we investigated the expression of a newly discovered gene, hRFI, which is isolated by the yeast two-hybrid screening using hTid as a bait and expressed highly in esophageal carcinomas [14].
  • In a recent study we reported that Tid1p, a protein previously implicated in recombination, is required for resolution of Mcd1p-dependent cohesion in meiosis [15].
 

Analytical, diagnostic and therapeutic context of DNAJA3

  • We have previously shown that hTid-1 and Hdj1, the human Hsp40/DnaJ chaperone proteins, bind the HBV core protein and inhibit viral replication in cell culture system [16].

References

  1. Molecular mechanism of hTid-1, the human homolog of Drosophila tumor suppressor l(2)Tid, in the regulation of NF-kappaB activity and suppression of tumor growth. Cheng, H., Cenciarelli, C., Nelkin, G., Tsan, R., Fan, D., Cheng-Mayer, C., Fidler, I.J. Mol. Cell. Biol. (2005) [Pubmed]
  2. Tid1 negatively regulates the migratory potential of cancer cells by inhibiting the production of interleukin-8. Kim, S.W., Hayashi, M., Lo, J.F., Fearns, C., Xiang, R., Lazennec, G., Yang, Y., Lee, J.D. Cancer Res. (2005) [Pubmed]
  3. HTLV-1 Tax-associated hTid-1, a human DnaJ protein, is a repressor of Ikappa B kinase beta subunit. Cheng, H., Cenciarelli, C., Tao, M., Parks, W.P., Cheng-Mayer, C. J. Biol. Chem. (2002) [Pubmed]
  4. Human T cell leukemia virus type 1 Tax associates with a molecular chaperone complex containing hTid-1 and Hsp70. Cheng, H., Cenciarelli, C., Shao, Z., Vidal, M., Parks, W.P., Pagano, M., Cheng-Mayer, C. Curr. Biol. (2001) [Pubmed]
  5. The human DnaJ protein, hTid-1, enhances binding of a multimer of the herpes simplex virus type 1 UL9 protein to oris, an origin of viral DNA replication. Eom, C.Y., Lehman, I.R. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  6. TID1, a human homolog of the Drosophila tumor suppressor l(2)tid, encodes two mitochondrial modulators of apoptosis with opposing functions. Syken, J., De-Medina, T., Münger, K. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  7. Tid1, a cochaperone of the heat shock 70 protein and the mammalian counterpart of the Drosophila tumor suppressor l(2)tid, is critical for early embryonic development and cell survival. Lo, J.F., Hayashi, M., Woo-Kim, S., Tian, B., Huang, J.F., Fearns, C., Takayama, S., Zapata, J.M., Yang, Y., Lee, J.D. Mol. Cell. Biol. (2004) [Pubmed]
  8. Genomic organization and expression of the human tumorous imaginal disc (TID1) gene. Yin, X., Rozakis-Adcock, M. Gene (2001) [Pubmed]
  9. Human tumorous imaginal disc 1 (TID1) associates with Trk receptor tyrosine kinases and regulates neurite outgrowth in nnr5-TrkA cells. Liu, H.Y., MacDonald, J.I., Hryciw, T., Li, C., Meakin, S.O. J. Biol. Chem. (2005) [Pubmed]
  10. Depletion of physiological levels of the human TID1 protein renders cancer cell lines resistant to apoptosis mediated by multiple exogenous stimuli. Edwards, K.M., Münger, K. Oncogene (2004) [Pubmed]
  11. Negative regulation of hepatitis B virus replication by cellular Hsp40/DnaJ proteins through destabilization of viral core and X proteins. Sohn, S.Y., Kim, S.B., Kim, J., Ahn, B.Y. J. Gen. Virol. (2006) [Pubmed]
  12. hTid-1, a human DnaJ protein, modulates the interferon signaling pathway. Sarkar, S., Pollack, B.P., Lin, K.T., Kotenko, S.V., Cook, J.R., Lewis, A., Pestka, S. J. Biol. Chem. (2001) [Pubmed]
  13. Tid1, the human homologue of a Drosophila tumor suppressor, reduces the malignant activity of ErbB-2 in carcinoma cells. Kim, S.W., Chao, T.H., Xiang, R., Lo, J.F., Campbell, M.J., Fearns, C., Lee, J.D. Cancer Res. (2004) [Pubmed]
  14. Effects of expression of hRFI on adenoma formation and tumor progression in colorectal adenoma-carcinoma sequence. Sasaki, S., Watanabe, T., Konishi, T., Kitayama, J., Nagawa, H. J. Exp. Clin. Cancer Res. (2004) [Pubmed]
  15. Sister chromatid cohesion remodeling and meiotic recombination. Kateneva, A.V., Dresser, M.E. Cell Cycle (2006) [Pubmed]
  16. Turnover of hepatitis B virus X protein is facilitated by Hdj1, a human Hsp40/DnaJ protein. Sohn, S.Y., Kim, J.H., Baek, K.W., Ryu, W.S., Ahn, B.Y. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
 
WikiGenes - Universities