Gene Review:
RABEP1 - rabaptin, RAB GTPase binding effector...
Homo sapiens
Synonyms:
RAB5EP, RABPT5, RABPT5A, Rab GTPase-binding effector protein 1, Rabaptin-4, ...
- Rabaptin-5 is a novel fusion partner to platelet-derived growth factor beta receptor in chronic myelomonocytic leukemia. Magnusson, M.K., Meade, K.E., Brown, K.E., Arthur, D.C., Krueger, L.A., Barrett, A.J., Dunbar, C.E. Blood (2001)
- Endocytic pathway alterations in human hippocampus after global ischemia and the influence of APOE genotype. McColl, B.W., Graham, D.I., Weir, C.J., White, F., Horsburgh, K. Am. J. Pathol. (2003)
- Expression of the endocytosis regulatory proteins Rab5 and Rabaptin-5 in glial cytoplasmic inclusions from brains with multiple system atrophy. Nakamura, S., Kawamoto, Y., Nakano, S., Akiguchi, I. Clin. Neuropathol. (2000)
- A novel Rab5 GDP/GTP exchange factor complexed to Rabaptin-5 links nucleotide exchange to effector recruitment and function. Horiuchi, H., Lippé, R., McBride, H.M., Rubino, M., Woodman, P., Stenmark, H., Rybin, V., Wilm, M., Ashman, K., Mann, M., Zerial, M. Cell (1997)
- Rabaptin-5 is a direct effector of the small GTPase Rab5 in endocytic membrane fusion. Stenmark, H., Vitale, G., Ullrich, O., Zerial, M. Cell (1995)
- Rabaptin-5alpha/rabaptin-4 serves as a linker between rab4 and gamma(1)-adaptin in membrane recycling from endosomes. Deneka, M., Neeft, M., Popa, I., van Oort, M., Sprong, H., Oorschot, V., Klumperman, J., Schu, P., van der Sluijs, P. EMBO J. (2003)
- Distinct Rab-binding domains mediate the interaction of Rabaptin-5 with GTP-bound Rab4 and Rab5. Vitale, G., Rybin, V., Christoforidis, S., Thornqvist, P., McCaffrey, M., Stenmark, H., Zerial, M. EMBO J. (1998)
- The neuronal growth-associated protein GAP-43 interacts with rabaptin-5 and participates in endocytosis. Neve, R.L., Coopersmith, R., McPhie, D.L., Santeufemio, C., Pratt, K.G., Murphy, C.J., Lynn, S.D. J. Neurosci. (1998)
- Human rabaptin-5 is selectively cleaved by caspase-3 during apoptosis. Swanton, E., Bishop, N., Woodman, P. J. Biol. Chem. (1999)
- Cleavage of rabaptin-5 blocks endosome fusion during apoptosis. Cosulich, S.C., Horiuchi, H., Zerial, M., Clarke, P.R., Woodman, P.G. EMBO J. (1997)
- Two distinct effectors of the small GTPase Rab5 cooperate in endocytic membrane fusion. Gournier, H., Stenmark, H., Rybin, V., Lippé, R., Zerial, M. EMBO J. (1998)
- Gamma-adaptin interacts directly with Rabaptin-5 through its ear domain. Shiba, Y., Takatsu, H., Shin, H.W., Nakayama, K. J. Biochem. (2002)
- The structure and function of GGAs, the traffic controllers at the TGN sorting crossroads. Nakayama, K., Wakatsuki, S. Cell Struct. Funct. (2003)
- The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis. Xiao, G.H., Shoarinejad, F., Jin, F., Golemis, E.A., Yeung, R.S. J. Biol. Chem. (1997)
- Recognition of accessory protein motifs by the gamma-adaptin ear domain of GGA3. Miller, G.J., Mattera, R., Bonifacino, J.S., Hurley, J.H. Nat. Struct. Biol. (2003)
- The trihelical bundle subdomain of the GGA proteins interacts with multiple partners through overlapping but distinct sites. Mattera, R., Puertollano, R., Smith, W.J., Bonifacino, J.S. J. Biol. Chem. (2004)
- Rabphilin dissociated from Rab3 promotes endocytosis through interaction with Rabaptin-5. Coppola, T., Hirling, H., Perret-Menoud, V., Gattesco, S., Catsicas, S., Joberty, G., Macara, I.G., Regazzi, R. J. Cell. Sci. (2001)
- Identification of rabaptin-5, rabex-5, and GM130 as putative effectors of rab33b, a regulator of retrograde traffic between the Golgi apparatus and ER. Valsdottir, R., Hashimoto, H., Ashman, K., Koda, T., Storrie, B., Nilsson, T. FEBS Lett. (2001)
- Selective membrane recruitment of EEA1 suggests a role in directional transport of clathrin-coated vesicles to early endosomes. Rubino, M., Miaczynska, M., Lippé, R., Zerial, M. J. Biol. Chem. (2000)
- The interaction of the human GGA1 GAT domain with rabaptin-5 is mediated by residues on its three-helix bundle. Zhai, P., He, X., Liu, J., Wakeham, N., Zhu, G., Li, G., Tang, J., Zhang, X.C. Biochemistry (2003)
- Multiple Rabaptin-5-like transcripts. Korobko, E.V., Kiselev, S.L., Korobko, I.V. Gene (2002)