Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

ECs0078 - 2-isopropylmalate synthase

Escherichia coli O157:H7 str. Sakai

Koon, N. et al., Honda, H. et al.

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Disease relevance of ECs0078

Crystallization and preliminary X-ray analysis of alpha-isopropylmalate synthase from Mycobacterium tuberculosis [1].
The 4.0 kb HindIII fragment could substitute for alpha-IPM synthetase gene of E. coli, and the 3.2 kb HindIII fragment could substitute for alpha-IPM isomerase gene of E. coli [2].

High impact information on ECs0078

alpha-Isopropylmalate synthase catalyses the aldol condensation of alpha-ketoisovalerate and acetyl coenzyme A to produce alpha-isopropylmalate [1].

References

Crystallization and preliminary X-ray analysis of alpha-isopropylmalate synthase from Mycobacterium tuberculosis. Koon, N., Squire, C.J., Baker, E.N. Acta Crystallogr. D Biol. Crystallogr. (2004) [Pubmed]
Cloning of leucine genes of alkalophilic Bacillus No. 221 in E. coli and B. subtilis. Honda, H., Kato, C., Kudo, T., Horikoshi, K. J. Biochem. (1984) [Pubmed]

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