Gene Review:
LPAR2 - lysophosphatidic acid receptor 2
Homo sapiens
Synonyms:
EDG-4, EDG4, LPA receptor 2, LPA-2, LPA2, ...
Shida,
Watanabe,
Aoki,
Hama,
Kitayama,
Sonoda,
Kishi,
Yamaguchi,
Sasaki,
Sako,
Konishi,
Arai,
Nagawa,
Panetti,
Shida,
Kitayama,
Yamaguchi,
Okaji,
Tsuno,
Watanabe,
Takuwa,
Nagawa,
Schulte,
Beyer,
Köhrer,
Oberhäuser,
Röher,
Shi,
Wang,
Wu,
Hazebroek,
Meeley,
Ertl,
Kitayama,
Shida,
Sako,
Ishikawa,
Hama,
Aoki,
Arai,
Nagawa,
Gonzalez,
Leavis,
- Lysophosphatidic acid, a novel lipid growth factor for human thyroid cells: over-expression of the high-affinity receptor edg4 in differentiated thyroid cancer. Schulte, K.M., Beyer, A., Köhrer, K., Oberhäuser, S., Röher, H.D. Int. J. Cancer (2001)
- Lysophosphatidic acid (LPA) enhances the metastatic potential of human colon carcinoma DLD1 cells through LPA1. Shida, D., Kitayama, J., Yamaguchi, H., Okaji, Y., Tsuno, N.H., Watanabe, T., Takuwa, Y., Nagawa, H. Cancer Res. (2003)
- Lysophosphatidic acid induction of vascular endothelial growth factor expression in human ovarian cancer cells. Hu, Y.L., Tee, M.K., Goetzl, E.J., Auersperg, N., Mills, G.B., Ferrara, N., Jaffe, R.B. J. Natl. Cancer Inst. (2001)
- Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization. An, S., Bleu, T., Zheng, Y., Goetzl, E.J. Mol. Pharmacol. (1998)
- Aberrant expression of lysophosphatidic acid (LPA) receptors in human colorectal cancer. Shida, D., Watanabe, T., Aoki, J., Hama, K., Kitayama, J., Sonoda, H., Kishi, Y., Yamaguchi, H., Sasaki, S., Sako, A., Konishi, T., Arai, H., Nagawa, H. Lab. Invest. (2004)
- NHERF2 specifically interacts with LPA2 receptor and defines the specificity and efficiency of receptor-mediated phospholipase C-beta3 activation. Oh, Y.S., Jo, N.W., Choi, J.W., Kim, H.S., Seo, S.W., Kang, K.O., Hwang, J.I., Heo, K., Kim, S.H., Kim, Y.H., Kim, I.H., Kim, J.H., Banno, Y., Ryu, S.H., Suh, P.G. Mol. Cell. Biol. (2004)
- The influence of lysophosphatidic acid on the functions of human dendritic cells. Panther, E., Idzko, M., Corinti, S., Ferrari, D., Herouy, Y., Mockenhaupt, M., Dichmann, S., Gebicke-Haerter, P., Di Virgilio, F., Girolomoni, G., Norgauer, J. J. Immunol. (2002)
- Lysophosphatidic acid-induced Ca2+ mobilization requires intracellular sphingosine 1-phosphate production. Potential involvement of endogenous EDG-4 receptors. Young, K.W., Bootman, M.D., Channing, D.R., Lipp, P., Maycox, P.R., Meakin, J., Challiss, R.A., Nahorski, S.R. J. Biol. Chem. (2000)
- Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid. Bandoh, K., Aoki, J., Hosono, H., Kobayashi, S., Kobayashi, T., Murakami-Murofushi, K., Tsujimoto, M., Arai, H., Inoue, K. J. Biol. Chem. (1999)
- LPA2 receptor mediates mitogenic signals in human colon cancer cells. Yun, C.C., Sun, H., Wang, D., Rusovici, R., Castleberry, A., Hall, R.A., Shim, H. Am. J. Physiol., Cell Physiol. (2005)
- Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid. An, S., Bleu, T., Hallmark, O.G., Goetzl, E.J. J. Biol. Chem. (1998)
- Cell density-dependent expression of EDG family receptors and mesangial cell proliferation: role in lysophosphatidic acid-mediated cell growth. Xing, Y., Ganji, S.H., Noh, J.W., Kamanna, V.S. Am. J. Physiol. Renal Physiol. (2004)
- Dual mechanisms for lysophosphatidic acid stimulation of human ovarian carcinoma cells. Hu, Y.L., Albanese, C., Pestell, R.G., Jaffe, R.B. J. Natl. Cancer Inst. (2003)
- Differential effects of sphingosine 1-phosphate and lysophosphatidic acid on endothelial cells. Panetti, T.S. Biochim. Biophys. Acta (2002)
- Lysophospholipid mediators of immunity and neoplasia. Huang, M.C., Graeler, M., Shankar, G., Spencer, J., Goetzl, E.J. Biochim. Biophys. Acta (2002)
- A peptide derived from the human leptin molecule is a potent inhibitor of the leptin receptor function in rabbit endometrial cells. Gonzalez, R.R., Leavis, P.C. Endocrine (2003)
- Induction of protein growth factor systems in the ovaries of transgenic mice overexpressing human type 2 lysophosphatidic acid G protein-coupled receptor (LPA2). Huang, M.C., Lee, H.Y., Yeh, C.C., Kong, Y., Zaloudek, C.J., Goetzl, E.J. Oncogene (2004)
- Synthesis of cyclic phosphonate analogues of (lyso)phosphatidic acid using a ring-closing metathesis reaction. Zhang, H., Tsukuhara, R., Tigyi, G., Prestwich, G.D. J. Org. Chem. (2006)
- EDG receptors as a potential therapeutic target in retinal ischemia-reperfusion injury. Savitz, S.I., Dhallu, M.S., Malhotra, S., Mammis, A., Ocava, L.C., Rosenbaum, P.S., Rosenbaum, D.M. Brain Res. (2006)
- Activity of 2-substituted lysophosphatidic acid (LPA) analogs at LPA receptors: discovery of a LPA1/LPA3 receptor antagonist. Heise, C.E., Santos, W.L., Schreihofer, A.M., Heasley, B.H., Mukhin, Y.V., Macdonald, T.L., Lynch, K.R. Mol. Pharmacol. (2001)
- Over-expression of lysophosphatidic acid receptor-2 in human invasive ductal carcinoma. Kitayama, J., Shida, D., Sako, A., Ishikawa, M., Hama, K., Aoki, J., Arai, H., Nagawa, H. Breast Cancer Res. (2004)
- The maize low-phytic acid mutant lpa2 is caused by mutation in an inositol phosphate kinase gene. Shi, J., Wang, H., Wu, Y., Hazebroek, J., Meeley, R.B., Ertl, D.S. Plant Physiol. (2003)