Gene Review:
CD4 - CD4 molecule
Homo sapiens
Synonyms:
T-cell surface antigen T4/Leu-3, T-cell surface glycoprotein CD4
Johnston,
Crepaldi,
Desai,
Tirelli,
Anthony DeVico,
Lane,
Leong,
Chaitt,
Kim,
Manhattan Charurat,
Giedlin,
Grünebach,
Dewar,
Hewson,
Butcher,
Behnke,
Simonelli,
Lindsey Galmin,
Moore,
Ma,
Ilia Harris,
Cotton,
Innes,
Heslop,
Fernandes,
Karla Godfrey,
Reichardt,
Sahner,
Moser,
Ramage,
De Paoli,
Kanz,
Cancio,
Zobywalski,
Timothy Fouts,
Comar,
George K. Lewis,
Giacca,
Nadler,
Robert C. Gallo,
Murphy,
Harrison,
D'Andrea,
Dewald,
Medders,
Pavia,
Duliege,
Lipton,
Talamini,
Boswell,
Ranajit Pal,
Bortolin,
Howie,
Baggiolini,
Stuhler,
Davey,
Kaul,
Brugger,
Capra,
Zanussi,
Kahn,
Brossart,
Graziano,
- Human chemokines: an update. Baggiolini, M., Dewald, B., Moser, B. Annu. Rev. Immunol. (1997)
- CD4-independent infection by HIV-2 is mediated by fusin/CXCR4. Endres, M.J., Clapham, P.R., Marsh, M., Ahuja, M., Turner, J.D., McKnight, A., Thomas, J.F., Stoebenau-Haggarty, B., Choe, S., Vance, P.J., Wells, T.N., Power, C.A., Sutterwala, S.S., Doms, R.W., Landau, N.R., Hoxie, J.A. Cell (1996)
- Human CD4-major histocompatibility complex class II (DQw6) transgenic mice in an endogenous CD4/CD8-deficient background: reconstitution of phenotype and human-restricted function. Yeung, R.S., Penninger, J.M., Kündig, T.M., Law, Y., Yamamoto, K., Kamikawaji, N., Burkly, L., Sasazuki, T., Flavell, R., Ohashi, P.S., Mak, T.W. J. Exp. Med. (1994)
- Effects of subcutaneous interleukin-2 therapy on CD4 subsets and in vitro cytokine production in HIV+ subjects. De Paoli, P., Zanussi, S., Simonelli, C., Bortolin, M.T., D'Andrea, M., Crepaldi, C., Talamini, R., Comar, M., Giacca, M., Tirelli, U. J. Clin. Invest. (1997)
- HIV-1 co-receptor expression on trophoblastic cells from early placentas and permissivity to infection by several HIV-1 primary isolates. Mognetti, B., Moussa, M., Croitoru, J., Menu, E., Dormont, D., Roques, P., Chaouat, G. Clin. Exp. Immunol. (2000)
- Immunologic and virologic effects of subcutaneous interleukin 2 in combination with antiretroviral therapy: A randomized controlled trial. Davey, R.T., Murphy, R.L., Graziano, F.M., Boswell, S.L., Pavia, A.T., Cancio, M., Nadler, J.P., Chaitt, D.G., Dewar, R.L., Sahner, D.K., Duliege, A.M., Capra, W.B., Leong, W.P., Giedlin, M.A., Lane, H.C., Kahn, J.O. JAMA (2000)
- HIV-1 coreceptors CCR5 and CXCR4 both mediate neuronal cell death but CCR5 paradoxically can also contribute to protection. Kaul, M., Ma, Q., Medders, K.E., Desai, M.K., Lipton, S.A. Cell Death Differ. (2007)
- Unscheduled cyclin B expression and p34 cdc2 activation in T lymphocytes from HIV-infected patients. Piedimonte, G., Corsi, D., Paiardini, M., Cannavò, G., Ientile, R., Picerno, I., Montroni, M., Silvestri, G., Magnani, M. AIDS (1999)
- Psychological profile in oral lichen planus. Ivanovski, K., Nakova, M., Warburton, G., Pesevska, S., Filipovska, A., Nares, S., Nunn, M.E., Angelova, D., Angelov, N. Journal of clinical periodontology. (2005)
- gp120: Biologic aspects of structural features. Poignard, P., Saphire, E.O., Parren, P.W., Burton, D.R. Annu. Rev. Immunol. (2001)
- Regulation of lymphocyte function by protein phosphorylation. Perlmutter, R.M., Levin, S.D., Appleby, M.W., Anderson, S.J., Alberola-Ila, J. Annu. Rev. Immunol. (1993)
- Immunity to intracellular bacteria. Kaufmann, S.H. Annu. Rev. Immunol. (1993)
- The T cell receptor as a multicomponent signalling machine: CD4/CD8 coreceptors and CD45 in T cell activation. Janeway, C.A. Annu. Rev. Immunol. (1992)
- Accessory receptors regulate coupling of the T-cell receptor complex to tyrosine kinase activation and mobilization of cytoplasmic calcium in T-lineage acute lymphoblastic leukemia. Ledbetter, J.A., Schieven, G.L., Kuebelbeck, V.M., Uckun, F.M. Blood (1991)
- A functional, discontinuous HIV-1 gp120 C3/C4 domain-derived, branched, synthetic peptide that binds to CD4 and inhibits MIP-1alpha chemokine binding. Howie, S.E., Fernandes, M.L., Heslop, I., Hewson, T.J., Cotton, G.J., Moore, M.J., Innes, D., Ramage, R., Harrison, D.J. FASEB J. (1999)
- CD4-independent use of Rhesus CCR5 by human immunodeficiency virus Type 2 implicates an electrostatic interaction between the CCR5 N terminus and the gp120 C4 domain. Lin, G., Lee, B., Haggarty, B.S., Doms, R.W., Hoxie, J.A. J. Virol. (2001)
- CD4-independent infection of astrocytes by human immunodeficiency virus type 1: requirement for the human mannose receptor. Liu, Y., Liu, H., Kim, B.O., Gattone, V.H., Li, J., Nath, A., Blum, J., He, J.J. J. Virol. (2004)
- The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1. Oberlin, E., Amara, A., Bachelerie, F., Bessia, C., Virelizier, J.L., Arenzana-Seisdedos, F., Schwartz, O., Heard, J.M., Clark-Lewis, I., Legler, D.F., Loetscher, M., Baggiolini, M., Moser, B. Nature (1996)
- HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Feng, Y., Broder, C.C., Kennedy, P.E., Berger, E.A. Science (1996)
- Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones. Salgame, P., Abrams, J.S., Clayberger, C., Goldstein, H., Convit, J., Modlin, R.L., Bloom, B.R. Science (1991)
- Evidence for differential intracellular signaling via CD4 and CD8 molecules. Ravichandran, K.S., Burakoff, S.J. J. Exp. Med. (1994)
- The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. Choe, H., Farzan, M., Sun, Y., Sullivan, N., Rollins, B., Ponath, P.D., Wu, L., Mackay, C.R., LaRosa, G., Newman, W., Gerard, N., Gerard, C., Sodroski, J. Cell (1996)
- Crystal structure of an HIV-binding recombinant fragment of human CD4. Ryu, S.E., Kwong, P.D., Truneh, A., Porter, T.G., Arthos, J., Rosenberg, M., Dai, X.P., Xuong, N.H., Axel, R., Sweet, R.W. Nature (1990)
- CD4-mediated stimulation of human eosinophils: lymphocyte chemoattractant factor and other CD4-binding ligands elicit eosinophil migration. Rand, T.H., Cruikshank, W.W., Center, D.M., Weller, P.F. J. Exp. Med. (1991)
- Dendritic cells freshly isolated from human blood express CD4 and mature into typical immunostimulatory dendritic cells after culture in monocyte-conditioned medium. O'Doherty, U., Steinman, R.M., Peng, M., Cameron, P.U., Gezelter, S., Kopeloff, I., Swiggard, W.J., Pope, M., Bhardwaj, N. J. Exp. Med. (1993)
- Chemokines and activated macrophages in HIV gp120-induced neuronal apoptosis. Kaul, M., Lipton, S.A. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Inhibition of CD4 cross-linking-induced lymphocytes apoptosis by vesnarinone as a novel immunomodulating agent: vesnarinone inhibits Fas expression and apoptosis by blocking cytokine secretion. Oyaizu, N., McCloskey, T.W., Than, S., Pahwa, S. Blood (1996)
- Trafficking machinery of NKT cells: shared and differential chemokine receptor expression among V alpha 24(+)V beta 11(+) NKT cell subsets with distinct cytokine-producing capacity. Kim, C.H., Johnston, B., Butcher, E.C. Blood (2002)
- Human IP-10 selectively promotes dominance of polyclonally activated and environmental antigen-driven IFN-gamma over IL-4 responses. Gangur, V., Simons, F.E., Hayglass, K.T. FASEB J. (1998)
- CD4 engagement by CD1d potentiates activation of CD4+ invariant NKT cells. Thedrez, A., de Lalla, C., Allain, S., Zaccagnino, L., Sidobre, S., Garavaglia, C., Borsellino, G., Dellabona, P., Bonneville, M., Scotet, E., Casorati, G. Blood (2007)
- Antibodies to CD4-induced sites in HIV gp120 correlate with the control of SHIV challenge in macaques vaccinated with subunit immunogens. DeVico, A., Fouts, T., Lewis, G.K., Gallo, R.C., Godfrey, K., Charurat, M., Harris, I., Galmin, L., Pal, R. Proc. Natl. Acad. Sci. U.S.A. (2007)
- A common CD4 gene variant is associated with an increased risk of HIV-1 infection in Kenyan female commercial sex workers. Oyugi, J.O., Vouriot, F.C., Alimonti, J., Wayne, S., Luo, M., Land, A.M., Ao, Z., Yao, X., Sekaly, R.P., Elliott, L.J., Simonsen, J.N., Ball, T.B., Jaoko, W., Kimani, J., Plummer, F.A., Fowke, K.R. J. Infect. Dis. (2009)
- CD4 binding site antibodies inhibit human immunodeficiency virus gp120 envelope glycoprotein interaction with CCR5. Raja, A., Venturi, M., Kwong, P., Sodroski, J. J. Virol. (2003)
- Binding of human immunodeficiency virus type 1 to CD4 and CXCR4 receptors differentially regulates expression of inflammatory genes and activates the MEK/ERK signaling pathway. Popik, W., Hesselgesser, J.E., Pitha, P.M. J. Virol. (1998)
- Functional mimicry of a human immunodeficiency virus type 1 coreceptor by a neutralizing monoclonal antibody. Xiang, S.H., Farzan, M., Si, Z., Madani, N., Wang, L., Rosenberg, E., Robinson, J., Sodroski, J. J. Virol. (2005)
- Physical associations between CD45 and CD4 or CD8 occur as late activation events in antigen receptor-stimulated human T cells. Mittler, R.S., Rankin, B.M., Kiener, P.A. J. Immunol. (1991)
- Legionella pneumophila protease inactivates interleukin-2 and cleaves CD4 on human T cells. Mintz, C.S., Miller, R.D., Gutgsell, N.S., Malek, T. Infect. Immun. (1993)
- Phorbol esters and SDF-1 induce rapid endocytosis and down modulation of the chemokine receptor CXCR4. Signoret, N., Oldridge, J., Pelchen-Matthews, A., Klasse, P.J., Tran, T., Brass, L.F., Rosenkilde, M.M., Schwartz, T.W., Holmes, W., Dallas, W., Luther, M.A., Wells, T.N., Hoxie, J.A., Marsh, M. J. Cell Biol. (1997)
- Molecular and functional analysis of a lymphocyte chemoattractant factor: association of biologic function with CD4 expression. Cruikshank, W.W., Center, D.M., Nisar, N., Wu, M., Natke, B., Theodore, A.C., Kornfeld, H. Proc. Natl. Acad. Sci. U.S.A. (1994)
- Vasoactive intestinal peptide generates human tolerogenic dendritic cells that induce CD4 and CD8 regulatory T cells. Gonzalez-Rey, E., Chorny, A., Fernandez-Martin, A., Ganea, D., Delgado, M. Blood (2006)
- Oligomerization of RANTES is required for CCR1-mediated arrest but not CCR5-mediated transmigration of leukocytes on inflamed endothelium. Baltus, T., Weber, K.S., Johnson, Z., Proudfoot, A.E., Weber, C. Blood (2003)
- Tumor necrosis factor alpha and CD40 ligand antagonize the inhibitory effects of interleukin 10 on T-cell stimulatory capacity of dendritic cells. Brossart, P., Zobywalski, A., Grünebach, F., Behnke, L., Stuhler, G., Reichardt, V.L., Kanz, L., Brugger, W. Cancer Res. (2000)
- CD4 coexpression regulates DC-SIGN-mediated transmission of human immunodeficiency virus type 1. Wang, J.H., Janas, A.M., Olson, W.J., KewalRamani, V.N., Wu, L. J. Virol. (2007)
- STRL33, A novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1. Liao, F., Alkhatib, G., Peden, K.W., Sharma, G., Berger, E.A., Farber, J.M. J. Exp. Med. (1997)
- Analysis of T cell stimulation by superantigen plus major histocompatibility complex class II molecules or by CD3 monoclonal antibody: costimulation by purified adhesion ligands VCAM-1, ICAM-1, but not ELAM-1. van Seventer, G.A., Newman, W., Shimizu, Y., Nutman, T.B., Tanaka, Y., Horgan, K.J., Gopal, T.V., Ennis, E., O'Sullivan, D., Grey, H. J. Exp. Med. (1991)
- A genetic approach to inactivating chemokine receptors using a modified viral protein. Coffield, V.M., Jiang, Q., Su, L. Nat. Biotechnol. (2003)
- Stable exposure of the coreceptor-binding site in a CD4-independent HIV-1 envelope protein. Hoffman, T.L., LaBranche, C.C., Zhang, W., Canziani, G., Robinson, J., Chaiken, I., Hoxie, J.A., Doms, R.W. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Intracellular cytokine profile of cord and adult blood lymphocytes. Chalmers, I.M., Janossy, G., Contreras, M., Navarrete, C. Blood (1998)
- Expression of the human immunodeficiency virus type-1 coreceptors CXCR-4 (fusin, LESTR) and CKR-5 in CD34+ hematopoietic progenitor cells. Deichmann, M., Kronenwett, R., Haas, R. Blood (1997)
- Two-color flow cytometry and functional analysis of lymphocytes cultured from human renal allografts: identification of a Leu-2+3+ subpopulation. Preffer, F.I., Colvin, R.B., Leary, C.P., Boyle, L.A., Tuazon, T.V., Lazarovits, A.I., Cosimi, A.B., Kurnick, J.T. J. Immunol. (1986)