Gene Review:
BMP15 - bone morphogenetic protein 15
Homo sapiens
Synonyms:
BMP-15, Bone morphogenetic protein 15, GDF-9B, GDF9B, Growth/differentiation factor 9B, ...
Aaltonen,
Laitinen,
Vuojolainen,
Jaatinen,
Horelli-Kuitunen,
Seppä,
Louhio,
Tuuri,
Sjöberg,
Bützow,
Hovata,
Dale,
Ritvos,
Wilson,
Wu,
Juengel,
Ross,
Lumsden,
Lord,
Dodds,
Walling,
McEwan,
O'Connell,
McNatty,
Montgomery,
McNatty,
Moore,
Hudson,
Quirke,
Lawrence,
Reader,
Hanrahan,
Smith,
Groome,
Laitinen,
Ritvos,
Juengel,
- Mutations in an oocyte-derived growth factor gene (BMP15) cause increased ovulation rate and infertility in a dosage-sensitive manner. Galloway, S.M., McNatty, K.P., Cambridge, L.M., Laitinen, M.P., Juengel, J.L., Jokiranta, T.S., McLaren, R.J., Luiro, K., Dodds, K.G., Montgomery, G.W., Beattie, A.E., Davis, G.H., Ritvos, O. Nat. Genet. (2000)
- Bone morphogenetic protein 15 (BMP15) alleles predict over-response to recombinant follicle stimulation hormone and iatrogenic ovarian hyperstimulation syndrome (OHSS). Morón, F.J., de Castro, F., Royo, J.L., Montoro, L., Mira, E., Sáez, M.E., Real, L.M., González, A., Mañes, S., Ruiz, A. Pharmacogenet. Genomics (2006)
- A unique preovulatory expression pattern plays a key role in the physiological functions of BMP-15 in the mouse. Yoshino, O., McMahon, H.E., Sharma, S., Shimasaki, S. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Hypergonadotropic ovarian failure associated with an inherited mutation of human bone morphogenetic protein-15 (BMP15) gene. Di Pasquale, E., Beck-Peccoz, P., Persani, L. Am. J. Hum. Genet. (2004)
- Effect of intracellular interactions on the processing and secretion of bone morphogenetic protein-15 (BMP-15) and growth and differentiation factor-9. Implication of the aberrant ovarian phenotype of BMP-15 mutant sheep. Liao, W.X., Moore, R.K., Otsuka, F., Shimasaki, S. J. Biol. Chem. (2003)
- Synergistic roles of BMP15 and GDF9 in the development and function of the oocyte-cumulus cell complex in mice: genetic evidence for an oocyte-granulosa cell regulatory loop. Su, Y.Q., Wu, X., O'Brien, M.J., Pendola, F.L., Denegre, J.N., Matzuk, M.M., Eppig, J.J. Dev. Biol. (2004)
- Bmp15 mutations and ovarian function. Galloway, S.M., Gregan, S.M., Wilson, T., McNatty, K.P., Juengel, J.L., Ritvos, O., Davis, G.H. Mol. Cell. Endocrinol. (2002)
- Mutational analysis of BMP15 and GDF9 as candidate genes for premature ovarian failure. Chand, A.L., Ponnampalam, A.P., Harris, S.E., Winship, I.M., Shelling, A.N. Fertil. Steril. (2006)
- The oocyte and its role in regulating ovulation rate: a new paradigm in reproductive biology. McNatty, K.P., Moore, L.G., Hudson, N.L., Quirke, L.D., Lawrence, S.B., Reader, K., Hanrahan, J.P., Smith, P., Groome, N.P., Laitinen, M., Ritvos, O., Juengel, J.L. Reproduction (2004)
- Missense mutations in the BMP15 gene are associated with ovarian failure. Dixit, H., Rao, L.K., Padmalatha, V.V., Kanakavalli, M., Deenadayal, M., Gupta, N., Chakrabarty, B., Singh, L. Hum. Genet. (2006)
- Oocyte-secreted factors enhance oocyte developmental competence. Hussein, T.S., Thompson, J.G., Gilchrist, R.B. Dev. Biol. (2006)
- Oocyte Bone Morphogenetic Protein 15, but not Growth Differentiation Factor 9, Is Increased During Gonadotropin-Induced Follicular Development in the Immature Mouse and Is Associated with Cumulus Oophorus Expansion. Gu??ripel, X., Brun, V., Gougeon, A. Biol. Reprod. (2006)
- Expression of mRNA encoding growth differentiation factor 9 and bone morphogenetic protein 15 during follicular formation and growth in a marsupial, the brushtail possum (Trichosurus vulpecula). Eckery, D.C., Whale, L.J., Lawrence, S.B., Wylde, K.A., McNatty, K.P., Juengel, J.L. Mol. Cell. Endocrinol. (2002)
- Synergistic roles of bone morphogenetic protein 15 and growth differentiation factor 9 in ovarian function. Yan, C., Wang, P., DeMayo, J., DeMayo, F.J., Elvin, J.A., Carino, C., Prasad, S.V., Skinner, S.S., Dunbar, B.S., Dube, J.L., Celeste, A.J., Matzuk, M.M. Mol. Endocrinol. (2001)
- Bone morphogenetic protein-15. Identification of target cells and biological functions. Otsuka, F., Yao, Z., Lee, T., Yamamoto, S., Erickson, G.F., Shimasaki, S. J. Biol. Chem. (2000)
- The human cumulus--oocyte complex gene-expression profile. Assou, S., Anahory, T., Pantesco, V., Le Carrour, T., Pellestor, F., Klein, B., Reyftmann, L., Dechaud, H., De Vos, J., Hamamah, S. Hum. Reprod. (2006)
- The activin-follistatin system and in vitro early follicle development in goats. Silva, J.R., Tharasanit, T., Taverne, M.A., van der Weijden, G.C., Santos, R.R., Figueiredo, J.R., van den Hurk, R. J. Endocrinol. (2006)
- Novel variants in growth differentiation factor 9 in mothers of dizygotic twins. Palmer, J.S., Zhao, Z.Z., Hoekstra, C., Hayward, N.K., Webb, P.M., Whiteman, D.C., Martin, N.G., Boomsma, D.I., Duffy, D.L., Montgomery, G.W. J. Clin. Endocrinol. Metab. (2006)
- Highly prolific Booroola sheep have a mutation in the intracellular kinase domain of bone morphogenetic protein IB receptor (ALK-6) that is expressed in both oocytes and granulosa cells. Wilson, T., Wu, X.Y., Juengel, J.L., Ross, I.K., Lumsden, J.M., Lord, E.A., Dodds, K.G., Walling, G.A., McEwan, J.C., O'Connell, A.R., McNatty, K.P., Montgomery, G.W. Biol. Reprod. (2001)
- Human growth differentiation factor 9 (GDF-9) and its novel homolog GDF-9B are expressed in oocytes during early folliculogenesis. Aaltonen, J., Laitinen, M.P., Vuojolainen, K., Jaatinen, R., Horelli-Kuitunen, N., Seppä, L., Louhio, H., Tuuri, T., Sjöberg, J., Bützow, R., Hovata, O., Dale, L., Ritvos, O. J. Clin. Endocrinol. Metab. (1999)
- The bone morphogenetic protein 15 gene is X-linked and expressed in oocytes. Dube, J.L., Wang, P., Elvin, J., Lyons, K.M., Celeste, A.J., Matzuk, M.M. Mol. Endocrinol. (1998)