Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

P - phosphoprotein

Avian paramyxovirus 6

McGinnes, L. et al., Oldoni, I. et al., Morrison, T. et al., Czeglédi, A. et al., Engel-Herbert, I. et al., et al.

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Disease relevance of P

Nucleotide sequence of the phosphoprotein (P) gene of Newcastle disease virus (strain Beaudette C) [1].
In contrast, birds immunized with the P gene containing retrovirus developed more severe clinical signs of disease earlier than birds receiving no immunization or retrovirus alone [2].
The nucleotide sequence of the P (phosphoprotein) gene of two strains of mumps virus has been determined from overlapping cDNA clones [3].

High impact information on P

Mechanism of interferon action. Characterization of sites of phosphorylation in the interferon-induced phosphoprotein P1 from mouse fibroblasts: evidence for two forms of P1 [4].
The nucleotide sequence of cloned cDNA copies of the mRNA encoding the Newcastle disease virus (NDV), strain AV, phosphoprotein (P) was determined [5].
Using truncated cDNA clones, evidence is presented that the 38,000- and 29,000-Da proteins are derived from initiation at AUG triplets in the same reading frame as the P protein [5].
The P protein and the nonstructural 38K and 29K proteins of Newcastle disease virus are derived from the same open reading frame [5].
To investigate the role of the fusion (F), hemagglutinin-neuraminidase (HN), and (P) phosphoprotein gene sequences in virulence, six strains of Newcastle disease virus (NDV) representing all pathotypes and seven recombinant strains created by reverse genetics were inoculated into 9-day-old chicken embryos [6].

Biological context of P

An ancient division in the primordial reservoir (wild waterbird species) led to two basal sister clades, class I and II, with genome sizes 15,198 (due to a 12 nucleotide insert in the phosphoprotein gene) and 15,186 nucleotides, respectively [7].
This plasmid transcribing antigenome RNA was cotransfected with helper plasmids expressing viral nucleoprotein, phosphoprotein and large protein into cells stably expressing T7 RNA polymerase [8].

Anatomical context of P

The P gene is also expressed from this vector in chick embryo cells [2].

Physical interactions of P

Regions on nucleocapsid protein of Newcastle disease virus that interact with its phosphoprotein [9].

Other interactions of P

The existence of these transcripts yields a transcription map order of NP, P, M, F0, HN [10].

References

Nucleotide sequence of the phosphoprotein (P) gene of Newcastle disease virus (strain Beaudette C). Daskalakis, S., Menke, J., Stripp, B., Stone, H. Nucleic Acids Res. (1992) [Pubmed]
Retroviral expressed hemagglutinin-neuraminidase protein protects chickens from Newcastle disease virus induced disease. Morrison, T., Hinshaw, V.S., Sheerar, M., Cooley, A.J., Brown, D., McQuain, C., McGinnes, L. Microb. Pathog. (1990) [Pubmed]
Molecular cloning and sequence analysis of the mumps virus gene encoding the P protein: mumps virus P gene is monocistronic. Takeuchi, K., Hishiyama, M., Yamada, A., Sugiura, A. J. Gen. Virol. (1988) [Pubmed]
Mechanism of interferon action. Characterization of sites of phosphorylation in the interferon-induced phosphoprotein P1 from mouse fibroblasts: evidence for two forms of P1. Lasky, S.R., Jacobs, B.L., Samuel, C.E. J. Biol. Chem. (1982) [Pubmed]
The P protein and the nonstructural 38K and 29K proteins of Newcastle disease virus are derived from the same open reading frame. McGinnes, L., McQuain, C., Morrison, T. Virology (1988) [Pubmed]
The use of in situ hybridization and immunohistochemistry to study the pathogenesis of various Newcastle disease virus strains and recombinants in embryonated chicken eggs. Oldoni, I., Brown, C.C., King, D.J., Samal, S., Seal, B.S. Microb. Pathog. (2005) [Pubmed]
Third genome size category of avian paramyxovirus serotype 1 (Newcastle disease virus) and evolutionary implications. Czeglédi, A., Ujvári, D., Somogyi, E., Wehmann, E., Werner, O., Lomniczi, B. Virus Res. (2006) [Pubmed]
Characterization of a recombinant Newcastle disease virus expressing the green fluorescent protein. Engel-Herbert, I., Werner, O., Teifke, J.P., Mebatsion, T., Mettenleiter, T.C., Römer-Oberdörfer, A. J. Virol. Methods (2003) [Pubmed]
Regions on nucleocapsid protein of Newcastle disease virus that interact with its phosphoprotein. Kho, C.L., Tan, W.S., Tey, B.T., Yusoff, K. Arch. Virol. (2004) [Pubmed]
Identification of the sequence content of four polycistronic transcripts synthesized in Newcastle disease virus infected cells. Wilde, A., McQuain, C., Morrison, T. Virus Res. (1986) [Pubmed]

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