Gene Review:
LRAT - lecithin retinol acyltransferase...
Homo sapiens
Synonyms:
LCA14, Lecithin retinol acyltransferase, Phosphatidylcholine--retinol O-acyltransferase
- Differential expression of the enzyme that esterifies retinol, lecithin:retinol acyltransferase, in subtypes of human renal cancer and normal kidney. Zhan, H.C., Gudas, L.J., Bok, D., Rando, R., Nanus, D.M., Tickoo, S.K. Clin. Cancer Res. (2003)
- Epidermal growth factor signaling pathway influences retinoid metabolism by reduction of retinyl ester hydrolase activities in normal and malignant keratinocytes. Jurukovski, V., Simon, M. J. Cell. Physiol. (2000)
- Expression of a smaller lecithin:retinol acyl transferase transcript and reduced retinol esterification in MCF-7 cells. Andreola, F., Giandomenico, V., Spero, R., De Luca, L.M. Biochem. Biophys. Res. Commun. (2000)
- Human melanomas of fibroblast and epithelial morphology differ widely in their ability to synthesize retinyl esters. Simmons, D.P., Andreola, F., De Luca, L.M. Carcinogenesis (2002)
- Screening Genes of the Retinoid Metabolism: Novel LRAT Mutation in Leber Congenital Amaurosis. S??n??chal, A., Humbert, G., Surget, M.O., Bazalgette, C., Bazalgette, C., Arnaud, B., Arndt, C., Laurent, E., Brabet, P., Hamel, C.P. Am. J. Ophthalmol. (2006)
- RPE65 is the isomerohydrolase in the retinoid visual cycle. Moiseyev, G., Chen, Y., Takahashi, Y., Wu, B.X., Ma, J.X. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Retinol metabolism and lecithin:retinol acyltransferase levels are reduced in cultured human prostate cancer cells and tissue specimens. Guo, X., Knudsen, B.S., Peehl, D.M., Ruiz, A., Bok, D., Rando, R.R., Rhim, J.S., Nanus, D.M., Gudas, L.J. Cancer Res. (2002)
- Retinoid absorption and storage is impaired in mice lacking lecithin:retinol acyltransferase (LRAT). O'Byrne, S.M., Wongsiriroj, N., Libien, J., Vogel, S., Goldberg, I.J., Baehr, W., Palczewski, K., Blaner, W.S. J. Biol. Chem. (2005)
- Cloning, gene organization and identification of an alternative splicing process in lecithin:retinol acyltransferase cDNA from human liver. Zolfaghari, R., Ross, A.C. Gene (2004)
- Reduced lecithin: retinol acyltransferase expression correlates with increased pathologic tumor stage in bladder cancer. Boorjian, S., Tickoo, S.K., Mongan, N.P., Yu, H., Bok, D., Rando, R.R., Nanus, D.M., Scherr, D.S., Gudas, L.J. Clin. Cancer Res. (2004)
- Lecithin retinol acyltransferase is a founder member of a novel family of enzymes. Jahng, W.J., Xue, L., Rando, R.R. Biochemistry (2003)
- Differential interaction of lecithin-retinol acyltransferase with cellular retinol binding proteins. Herr, F.M., Ong, D.E. Biochemistry (1992)
- Lack of fundus autofluorescence to 488 nanometers from childhood on in patients with early-onset severe retinal dystrophy associated with mutations in RPE65. Lorenz, B., Wabbels, B., Wegscheider, E., Hamel, C.P., Drexler, W., Preising, M.N. Ophthalmology (2004)
- Regulation of hepatic retinol metabolism: perspectives from studies on vitamin A status. Ross, A.C., Zolfaghari, R. J. Nutr. (2004)
- Differential gene expression profiles of radioresistant pancreatic cancer cell lines established by fractionated irradiation. Ogawa, K., Utsunomiya, T., Mimori, K., Tanaka, F., Haraguchi, N., Inoue, H., Murayama, S., Mori, M. Int. J. Oncol. (2006)
- Visual cycle retinoid processing proteins are present in HEK293S cells. Chen, Y., Moiseyev, G., Wu, B.X., Ma, J.X., Crouch, R.K. Vision Res. (2003)
- Cloning and molecular expression analysis of large and small lecithin:retinol acyltransferase mRNAs in the liver and other tissues of adult rats. Zolfaghari, R., Wang, Y., Chen, Q., Sancher, A., Ross, A.C. Biochem. J. (2002)