Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

TIFA - TRAF-interacting protein with forkhead...

Homo sapiens

Synonyms: MGC20791, T2BP, T6BP, TIFAA, TRAF-interacting protein with FHA domain-containing protein A, ...

Ea, C.K. et al., Matsumura, T. et al., Chang, M.X. et al., Inoue, J. et al., Kanamori, M. et al., et al.

Inoue, Yagi, Ishikawa, Azuma, Ikawa, Semba,

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High impact information on TIFA

Importantly, TIFA induces the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism [1].
In transient transfection assays, TIFA activates NFkappaBeta and c-Jun amino-terminal kinase [2].
Identification and characterization of Xenopus laevis homologs of mammalian TRAF6 and its binding protein TIFA [3].
TIFAB inhibits TIFA, TRAF-interacting protein with a forkhead-associated domain [4].
TIFAB does not associate with members of the TRAF family but does bind TIFA [4].

Physical interactions of TIFA

A tumor necrosis factor receptor-associated factor 2 binding protein (T2BP) gene was isolated from the grass carp (Ctenopharyngodon idellus) by utilizing suppression subtractive hybridization (SSH) and rapid amplification of cDNA ends (RACE) [5].

Regulatory relationships of TIFA

TIFA activates IkappaB kinase (IKK) by promoting oligomerization and ubiquitination of TRAF6 [1].

Other interactions of TIFA

We show that recombinant TIFA protein, but not TRAF6-binding-defective mutant, can activate IKK in crude cytosolic extracts [1].
We report identification of a TIFA-related protein, TIFAB, that inhibits TIFA-mediated activation of NFkappaB [4].
Our results suggest that T2BP is involved in the TNF-mediated signaling by its interaction with TRAF2 [6].

References

TIFA activates IkappaB kinase (IKK) by promoting oligomerization and ubiquitination of TRAF6. Ea, C.K., Sun, L., Inoue, J., Chen, Z.J. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
Identification of TIFA as an adapter protein that links tumor necrosis factor receptor-associated factor 6 (TRAF6) to interleukin-1 (IL-1) receptor-associated kinase-1 (IRAK-1) in IL-1 receptor signaling. Takatsuna, H., Kato, H., Gohda, J., Akiyama, T., Moriya, A., Okamoto, Y., Yamagata, Y., Otsuka, M., Umezawa, K., Semba, K., Inoue, J. J. Biol. Chem. (2003) [Pubmed]
Identification and characterization of Xenopus laevis homologs of mammalian TRAF6 and its binding protein TIFA. Inoue, J., Yagi, S., Ishikawa, K., Azuma, S., Ikawa, S., Semba, K. Gene (2005) [Pubmed]
TIFAB inhibits TIFA, TRAF-interacting protein with a forkhead-associated domain. Matsumura, T., Semba, K., Azuma, S., Ikawa, S., Gohda, J., Akiyama, T., Inoue, J. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
Molecular cloning of TRAF2 binding protein gene and its promoter region from the grass carp Ctenopharyngodon idellus. Chang, M.X., Nie, P., Sun, B.J., Yao, W.J. Vet. Immunol. Immunopathol. (2005) [Pubmed]
T2BP, a novel TRAF2 binding protein, can activate NF-kappaB and AP-1 without TNF stimulation. Kanamori, M., Suzuki, H., Saito, R., Muramatsu, M., Hayashizaki, Y. Biochem. Biophys. Res. Commun. (2002) [Pubmed]

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