Gene Review:
KLF4 - Kruppel-like factor 4 (gut)
Homo sapiens
Synonyms:
EZF, Epithelial zinc finger protein EZF, GKLF, Gut-enriched krueppel-like factor, Krueppel-like factor 4
- Requirement of Krüppel-like factor 4 in preventing entry into mitosis following DNA damage. Yoon, H.S., Yang, V.W. J. Biol. Chem. (2004)
- Overexpression of Krüppel-like factor 4 in the human colon cancer cell line RKO leads to reduced tumorigenecity. Dang, D.T., Chen, X., Feng, J., Torbenson, M., Dang, L.H., Yang, V.W. Oncogene (2003)
- Expression of the gut-enriched Krüppel-like factor (Krüppel-like factor 4) gene in the human colon cancer cell line RKO is dependent on CDX2. Dang, D.T., Mahatan, C.S., Dang, L.H., Agboola, I.A., Yang, V.W. Oncogene (2001)
- Drastic down-regulation of Krüppel-like factor 4 expression is critical in human gastric cancer development and progression. Wei, D., Gong, W., Kanai, M., Schlunk, C., Wang, L., Yao, J.C., Wu, T.T., Huang, S., Xie, K. Cancer Res. (2005)
- Putative tumor-suppressive function of Kruppel-like factor 4 in primary lung carcinoma. Hu, W., Hofstetter, W.L., Li, H., Zhou, Y., He, Y., Pataer, A., Wang, L., Xie, K., Swisher, S.G., Fang, B. Clin. Cancer Res. (2009)
- Klf4 is a transcription factor required for establishing the barrier function of the skin. Segre, J.A., Bauer, C., Fuchs, E. Nat. Genet. (1999)
- Loss of Klf4 in mice causes altered proliferation and differentiation and precancerous changes in the adult stomach. Katz, J.P., Perreault, N., Goldstein, B.G., Actman, L., McNally, S.R., Silberg, D.G., Furth, E.E., Kaestner, K.H. Gastroenterology (2005)
- The keratin 19 promoter is potent for cell-specific targeting of genes in transgenic mice. Brembeck, F.H., Moffett, J., Wang, T.C., Rustgi, A.K. Gastroenterology (2001)
- Kruppel-like factor 4 mediates p53-dependent G1/S cell cycle arrest in response to DNA damage. Yoon, H.S., Chen, X., Yang, V.W. J. Biol. Chem. (2003)
- Kruppel-like factor 4 (KLF4) represses histidine decarboxylase gene expression through an upstream Sp1 site and downstream gastrin responsive elements. Ai, W., Liu, Y., Langlois, M., Wang, T.C. J. Biol. Chem. (2004)
- The Krüppel-like transcriptional factors Zf9 and GKLF coactivate the human keratin 4 promoter and physically interact. Okano, J., Opitz, O.G., Nakagawa, H., Jenkins, T.D., Friedman, S.L., Rustgi, A.K. FEBS Lett. (2000)
- Krüppel-like factor 4 is transactivated by butyrate in colon cancer cells. Chen, Z.Y., Rex, S., Tseng, C.C. J. Nutr. (2004)
- Downregulation and growth inhibitory effect of epithelial-type Krüppel-like transcription factor KLF4, but not KLF5, in bladder cancer. Ohnishi, S., Ohnami, S., Laub, F., Aoki, K., Suzuki, K., Kanai, Y., Haga, K., Asaka, M., Ramirez, F., Yoshida, T. Biochem. Biophys. Res. Commun. (2003)
- Activation of the human pregnancy-specific glycoprotein PSG-5 promoter by KLF4 and Sp1. Blanchon, L., Nores, R., Gallot, D., Marceau, G., Borel, V., Yang, V.W., Bocco, J.L., Lémery, D., Panzetta-Dutari, G., Sapin, V. Biochem. Biophys. Res. Commun. (2006)
- The Kruppel-like KLF4 transcription factor, a novel regulator of urokinase receptor expression, drives synthesis of this binding site in colonic crypt luminal surface epithelial cells. Wang, H., Yang, L., Jamaluddin, M.S., Boyd, D.D. J. Biol. Chem. (2004)
- The leukocyte integrin gene CD11d is repressed by gut-enriched Kruppel-like factor 4 in myeloid cells. Noti, J.D., Johnson, A.K., Dillon, J.D. J. Biol. Chem. (2005)
- Destabilization of Krüppel-like factor 4 protein in response to serum stimulation involves the ubiquitin-proteasome pathway. Chen, Z.Y., Wang, X., Zhou, Y., Offner, G., Tseng, C.C. Cancer Res. (2005)
- STAT1 is required for IFN-gamma-mediated gut-enriched Krüppel-like factor expression. Chen, Z.Y., Shie, J.L., Tseng, C.C. Exp. Cell Res. (2002)
- Gut-enriched kruppel-like factor interaction with smad3 inhibits myofibroblast differentiation. Hu, B., Wu, Z., Liu, T., Ullenbruch, M.R., Jin, H., Phan, S.H. Am. J. Respir. Cell Mol. Biol. (2007)
- Transactivation and growth suppression by the gut-enriched Krüppel-like factor (Krüppel-like factor 4) are dependent on acidic amino acid residues and protein-protein interaction. Geiman, D.E., Ton-That, H., Johnson, J.M., Yang, V.W. Nucleic Acids Res. (2000)
- Krüppel-like factor 4 prevents centrosome amplification following gamma-irradiation-induced DNA damage. Yoon, H.S., Ghaleb, A.M., Nandan, M.O., Hisamuddin, I.M., Dalton, W.B., Yang, V.W. Oncogene (2005)
- Transcriptional profiling of Krüppel-like factor 4 reveals a function in cell cycle regulation and epithelial differentiation. Chen, X., Whitney, E.M., Gao, S.Y., Yang, V.W. J. Mol. Biol. (2003)
- Cell and tissue specific expression of human Krüppel-like transcription factors in human ocular surface. Chiambaretta, F., De Graeve, F., Turet, G., Marceau, G., Gain, P., Dastugue, B., Rigal, D., Sapin, V. Mol. Vis. (2004)