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ZNHIT3  -  zinc finger, HIT-type containing 3

Homo sapiens

Synonyms: HNF-4a coactivator, TR-interacting protein 3, TRIP-3, TRIP3, Thyroid hormone receptor interactor 3, ...
 
 
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High impact information on ZNHIT3

  • Mutation screening revealed that variation of the Trip3 gene is not a common cause of MODY/early-onset type 2 diabetes in Japanese individuals [1].
  • In the present study, we showed, using a yeast two-hybrid screening assay, that thyroid hormone receptor interacting protein 3 (Trip3) interacted with HNF-4alpha, and their interaction was confirmed by the glutathione S-transferase pull-down assay [1].
  • Human Trip3 cDNA contained an open reading frame for a protein of 155 amino acids, and the gene was expressed in both pancreatic islets and MIN6 cells [1].
  • Thyroid hormone receptor interacting protein 3 (trip3) is a novel coactivator of hepatocyte nuclear factor-4alpha [1].
  • Trip3 may play an important role in glucose metabolism by regulating the transcription activity of HNF-4alpha [1].
 

Anatomical context of ZNHIT3

  • Cotransfection experiments indicated that Trip3 could enhance (two- to threefold) the transcription activity of HNF-4alpha in COS-7 cells and MIN6 cells [1].
 

Associations of ZNHIT3 with chemical compounds

  • An additional co-activator, Trip3, was isolated by differential mRNA display and shown to be preferentially induced by 9-cis retinoic acid in SH SY 5Y and SH S EP cells [2].

References

  1. Thyroid hormone receptor interacting protein 3 (trip3) is a novel coactivator of hepatocyte nuclear factor-4alpha. Iwahashi, H., Yamagata, K., Yoshiuchi, I., Terasaki, J., Yang, Q., Fukui, K., Ihara, A., Zhu, Q., Asakura, T., Cao, Y., Imagawa, A., Namba, M., Hanafusa, T., Miyagawa, J., Matsuzawa, Y. Diabetes (2002) [Pubmed]
  2. Differential effects of retinoic acid isomers on the expression of nuclear receptor co-regulators in neuroblastoma. Lovat, P.E., Annicchiarico-Petruzzelli, M., Corazzari, M., Dobson, M.G., Malcolm, A.J., Pearson, A.D., Melino, G., Redfern, C.P. FEBS Lett. (1999) [Pubmed]
 
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