Gene Review:
SLC22A6 - solute carrier family 22 (organic anion...
Homo sapiens
Synonyms:
HOAT1, OAT1, Organic anion transporter 1, PAH transporter, PAHT, ...
Truong,
Cihlar,
Zalups,
Ahmad,
Fuzesï,
Zabel,
Lang,
Eraly,
Hamilton,
Buttler,
Enklaar,
Burckhardt,
Bahn,
Reid,
Hagos,
Burckhardt,
Dantzler,
Füzesi,
Wolff,
Ebbinghaus,
Kuhnke,
Sweet,
Burckhardt,
Gunawan,
Burckhardt,
Vormfelde,
Toliat,
Ponimaskin,
Nigam,
Hesse,
Holzinger,
Lin,
Hagos,
Xu,
Wu,
Ebbinghaus,
Bhatnagar,
Fuller,
Thies,
Nigam,
Mendel,
Brockmöller,
Hillemann,
Gekle,
Nürnberg,
Reid,
Vaughn,
Sauvant,
Friedrich,
Eraly,
Evans,
Meineke,
Bahn,
Schirmer,
Ebbinghaus,
Pritchard,
Prawitt,
Sweet,
Wolff,
Schulten,
Engelhardt,
Bush,
- Homocysteine and the renal epithelial transport and toxicity of inorganic mercury: role of basolateral transporter organic anion transporter 1. Zalups, R.K., Ahmad, S. J. Am. Soc. Nephrol. (2004)
- Accumulation of Indoxyl Sulfate in OAT1/3-Positive Tubular Cells in Kidneys of Patients With Chronic Renal Failure. Taki, K., Nakamura, S., Miglinas, M., Enomoto, A., Niwa, T. Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation. (2006)
- Renal elimination of p-aminohippurate (PAH) in response to three days of biliary obstruction in the rat. The role of OAT1 and OAT3. Brandoni, A., Anzai, N., Kanai, Y., Endou, H., Torres, A.M. Biochim. Biophys. Acta (2006)
- A Three-dimensional Model of Human Organic Anion Transporter 1: AROMATIC AMINO ACIDS REQUIRED FOR SUBSTRATE TRANSPORT. Perry, J.L., Dembla-Rajpal, N., Hall, L.A., Pritchard, J.B. J. Biol. Chem. (2006)
- Correction of ornithine-delta-aminotransferase deficiency in a Chinese hamster ovary cell line mediated by retrovirus gene transfer. Lacorazza, H.D., Jendoubi, M. Gene Ther. (1995)
- The ornithine aminotransferase (OAT) locus: analysis of RFLPs in gyrate atrophy. Ramesh, V., Benoit, L.A., Crawford, P., Harvey, P.T., Shows, T.B., Shih, V.E., Gusella, J.F. Am. J. Hum. Genet. (1988)
- Role of glycosylation in the organic anion transporter OAT1. Tanaka, K., Xu, W., Zhou, F., You, G. J. Biol. Chem. (2004)
- Human renal organic anion transporter 1-dependent uptake and toxicity of mercuric-thiol conjugates in Madin-Darby canine kidney cells. Aslamkhan, A.G., Han, Y.H., Yang, X.P., Zalups, R.K., Pritchard, J.B. Mol. Pharmacol. (2003)
- Human renal organic anion transporter 1 (hOAT1) and its role in the nephrotoxicity of antiviral nucleotide analogs. Cihlar, T., Ho, E.S., Lin, D.C., Mulato, A.S. Nucleosides Nucleotides Nucleic Acids (2001)
- Functional consequences of single nucleotide polymorphisms in the human organic anion transporter hOAT1 (SLC22A6). Bleasby, K., Hall, L.A., Perry, J.L., Mohrenweiser, H.W., Pritchard, J.B. J. Pharmacol. Exp. Ther. (2005)
- Torsemide renal clearance and genetic variation in luminal and basolateral organic anion transporters. Vormfelde, S.V., Schirmer, M., Hagos, Y., Toliat, M.R., Engelhardt, S., Meineke, I., Burckhardt, G., Nürnberg, P., Brockmöller, J. British journal of clinical pharmacology. (2006)
- Analyses of 5' regulatory region polymorphisms in human SLC22A6 (OAT1) and SLC22A8 (OAT3). Bhatnagar, V., Xu, G., Hamilton, B.A., Truong, D.M., Eraly, S.A., Wu, W., Nigam, S.K. J. Hum. Genet. (2006)
- Transport of the natural sweetener stevioside and its aglycone steviol by human organic anion transporter (hOAT1; SLC22A6) and hOAT3 (SLC22A8). Srimaroeng, C., Chatsudthipong, V., Aslamkhan, A.G., Pritchard, J.B. J. Pharmacol. Exp. Ther. (2005)
- Protein kinase C activation downregulates human organic anion transporter 1-mediated transport through carrier internalization. Wolff, N.A., Thies, K., Kuhnke, N., Reid, G., Friedrich, B., Lang, F., Burckhardt, G. J. Am. Soc. Nephrol. (2003)
- The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1. Cihlar, T., Lin, D.C., Pritchard, J.B., Fuller, M.D., Mendel, D.B., Sweet, D.H. Mol. Pharmacol. (1999)
- Methotrexate-loxoprofen interaction: involvement of human organic anion transporters hOAT1 and hOAT3. Uwai, Y., Taniguchi, R., Motohashi, H., Saito, H., Okuda, M., Inui, K. Drug Metab. Pharmacokinet. (2004)
- Characterization of the Uptake of Organic Anion Transporter (OAT) 1 and OAT3 Substrates by Human Kidney Slices. Nozaki, Y., Kusuhara, H., Kondo, T., Hasegawa, M., Shiroyanagi, Y., Nakazawa, H., Okano, T., Sugiyama, Y. J. Pharmacol. Exp. Ther. (2007)
- Renal Transport of Adefovir, Cidofovir, and Tenofovir by SLC22A Family Members (hOAT1, hOAT3, and hOCT2). Uwai, Y., Ida, H., Tsuji, Y., Katsura, T., Inui, K. Pharm. Res. (2007)
- Human organic anion transporters mediate the transport of tetracycline. Babu, E., Takeda, M., Narikawa, S., Kobayashi, Y., Yamamoto, T., Cha, S.H., Sekine, T., Sakthisekaran, D., Endou, H. Jpn. J. Pharmacol. (2002)
- The chloride dependence of the human organic anion transporter 1 (hOAT1) is blunted by mutation of a single amino acid. Rizwan, A.N., Krick, W., Burckhardt, G. J. Biol. Chem. (2007)
- Gene expression levels and immunolocalization of organic ion transporters in the human kidney. Motohashi, H., Sakurai, Y., Saito, H., Masuda, S., Urakami, Y., Goto, M., Fukatsu, A., Ogawa, O., Inui, K. J. Am. Soc. Nephrol. (2002)
- Action of EGF and PGE2 on basolateral organic anion uptake in rabbit proximal renal tubules and hOAT1 expressed in human kidney epithelial cells. Sauvant, C., Hesse, D., Holzinger, H., Evans, K.K., Dantzler, W.H., Gekle, M. Am. J. Physiol. Renal Physiol. (2004)
- Different transport properties between famotidine and cimetidine by human renal organic ion transporters (SLC22A). Motohashi, H., Uwai, Y., Hiramoto, K., Okuda, M., Inui, K. Eur. J. Pharmacol. (2004)
- Development of High-specificity Antibodies against Renal Urate Transporters Using Genetic Immunization. Xu, G., Chen, X., Wu, D., Shi, S., Wang, J., Ding, R., Hong, Q., Feng, Z., Lin, S., Lu, Y. J. Biochem. Mol. Biol. (2006)
- Molecular cloning and functional analyses of OAT1 and OAT3 from cynomolgus monkey kidney. Tahara, H., Shono, M., Kusuhara, H., Kinoshita, H., Fuse, E., Takadate, A., Otagiri, M., Sugiyama, Y. Pharm. Res. (2005)
- Organic anion and cation transporter expression and function during embryonic kidney development and in organ culture models. Sweet, D.H., Eraly, S.A., Vaughn, D.A., Bush, K.T., Nigam, S.K. Kidney Int. (2006)
- Expression studies and functional characterization of renal human organic anion transporter 1 isoforms. Bahn, A., Ebbinghaus, C., Ebbinghaus, D., Ponimaskin, E.G., Fuzesï, L., Burckhardt, G., Hagos, Y. Drug Metab. Dispos. (2004)
- Genomic structure and in vivo expression of the human organic anion transporter 1 (hOAT1) gene. Bahn, A., Prawitt, D., Buttler, D., Reid, G., Enklaar, T., Wolff, N.A., Ebbinghaus, C., Hillemann, A., Schulten, H.J., Gunawan, B., Füzesi, L., Zabel, B., Burckhardt, G. Biochem. Biophys. Res. Commun. (2000)
- Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney. Hosoyamada, M., Sekine, T., Kanai, Y., Endou, H. Am. J. Physiol. (1999)