Gene Review:
COX5A - cytochrome c oxidase subunit Va
Homo sapiens
Synonyms:
COX, COX-VA, Cytochrome c oxidase polypeptide Va, Cytochrome c oxidase subunit 5A, mitochondrial, VA
Niederberger,
Manderscheid,
Grösch,
Schmidt,
Ehnert,
Geisslinger,
Yokota,
Terada,
Ishihara,
Nakashima,
Kugo,
Ujike,
Tsuchiya,
Ikeda,
Saito,
Murayama,
Ishizu,
Kuroda,
Denkert,
Fürstenberg,
Daniel,
Koch,
Köbel,
Weichert,
Siegert,
Hauptmann,
Alique,
Herrero,
Lucio-Cazana,
Garavito,
Mulichak,
Teraoka,
Yokoyama,
Ninomiya,
Inoue,
Yamashita,
Seino,
Lim,
Rice,
Kelloff,
Sullivan,
Driggers,
Beard,
Kuwada,
Piazza,
Ahnen,
Chowdhury,
Bader,
Lee,
- Constitutive knockout of Surf1 is associated with high embryonic lethality, mitochondrial disease and cytochrome c oxidase deficiency in mice. Agostino, A., Invernizzi, F., Tiveron, C., Fagiolari, G., Prelle, A., Lamantea, E., Giavazzi, A., Battaglia, G., Tatangelo, L., Tiranti, V., Zeviani, M. Hum. Mol. Genet. (2003)
- All-trans retinoic acid induces COX-2 and prostaglandin E2 synthesis in SH-SY5Y human neuroblastoma cells: involvement of retinoic acid receptors and extracellular-regulated kinase 1/2. Alique, M., Herrero, J.F., Lucio-Cazana, F.J. Journal of neuroinflammation (2007)
- Resveratrol-induced cyclooxygenase-2 facilitates p53-dependent apoptosis in human breast cancer cells. Tang, H.Y., Shih, A., Cao, H.J., Davis, F.B., Davis, P.J., Lin, H.Y. Mol. Cancer Ther. (2006)
- SURF1, encoding a factor involved in the biogenesis of cytochrome c oxidase, is mutated in Leigh syndrome. Zhu, Z., Yao, J., Johns, T., Fu, K., De Bie, I., Macmillan, C., Cuthbert, A.P., Newbold, R.F., Wang, J., Chevrette, M., Brown, G.K., Brown, R.M., Shoubridge, E.A. Nat. Genet. (1998)
- A systematic mutation screen of 10 nuclear and 25 mitochondrial candidate genes in 21 patients with cytochrome c oxidase (COX) deficiency shows tRNA(Ser)(UCN) mutations in a subgroup with syndromal encephalopathy. Jaksch, M., Hofmann, S., Kleinle, S., Liechti-Gallati, S., Pongratz, D.E., Müller-Höcker, J., Jedele, K.B., Meitinger, T., Gerbitz, K.D. J. Med. Genet. (1998)
- Selective cyclooxygenase-2 inhibitors. Golden, B.D., Abramson, S.B. Rheum. Dis. Clin. North Am. (1999)
- Neuronal expression of cyclooxygenase-2, a pro-inflammatory protein, in the hippocampus of patients with schizophrenia. Yokota, O., Terada, S., Ishihara, T., Nakashima, H., Kugo, A., Ujike, H., Tsuchiya, K., Ikeda, K., Saito, Y., Murayama, S., Ishizu, H., Kuroda, S. Prog. Neuropsychopharmacol. Biol. Psychiatry (2004)
- INCREASES IN COX II mRNA IN THE RAT SPINAL CORD INDUCED BY CAUDA EQUINA TRACTION. Hirabayashi, K., Komagata, M., Yamada, J., Isshiki, A., Watanabe, Y. Int. J. Neurosci. (2006)
- Characteristics of the experimental reflex sleep induced by vago-aortic nerve stimulation. Puizillout, J.J., Foutz, A.S. Electroencephalography and clinical neurophysiology. (1977)
- Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons. Kraytsberg, Y., Kudryavtseva, E., McKee, A.C., Geula, C., Kowall, N.W., Khrapko, K. Nat. Genet. (2006)
- Fatal infantile cardioencephalomyopathy with COX deficiency and mutations in SCO2, a COX assembly gene. Papadopoulou, L.C., Sue, C.M., Davidson, M.M., Tanji, K., Nishino, I., Sadlock, J.E., Krishna, S., Walker, W., Selby, J., Glerum, D.M., Coster, R.V., Lyon, G., Scalais, E., Lebel, R., Kaplan, P., Shanske, S., De Vivo, D.C., Bonilla, E., Hirano, M., DiMauro, S., Schon, E.A. Nat. Genet. (1999)
- Induction of G0/G1 cell cycle arrest in ovarian carcinoma cells by the anti-inflammatory drug NS-398, but not by COX-2-specific RNA interference. Denkert, C., Fürstenberg, A., Daniel, P.T., Koch, I., Köbel, M., Weichert, W., Siegert, A., Hauptmann, S. Oncogene (2003)
- Binding of copper is a mechanism of homocysteine toxicity leading to COX deficiency and apoptosis in primary neurons, PC12 and SHSY-5Y cells. Linnebank, M., Lutz, H., Jarre, E., Vielhaber, S., Noelker, C., Struys, E., Jakobs, C., Klockgether, T., Evert, B.O., Kunz, W.S., Wüllner, U. Neurobiol. Dis. (2006)
- High response rate in the phase I/II study of meloxicam in juvenile rheumatoid arthritis. Foeldvari, I., Burgos-Vargas, R., Thon, A., Tuerck, D. J. Rheumatol. (2002)
- Synthesis of interleukin 1beta, tumor necrosis factor-alpha, and interstitial collagenase (MMP-1) is eicosanoid dependent in human osteoarthritis synovial membrane explants: interactions with antiinflammatory cytokines. He, W., Pelletier, J.P., Martel-Pelletier, J., Laufer, S., Di Battista, J.A. J. Rheumatol. (2002)
- COX-3 and the mechanism of action of paracetamol/acetaminophen. Botting, R., Ayoub, S.S. Prostaglandins Leukot. Essent. Fatty Acids (2005)
- A Novel Positive Feedback Loop between Peroxisome Proliferator-activated Receptor-{delta} and Prostaglandin E2 Signaling Pathways for Human Cholangiocarcinoma Cell Growth. Xu, L., Han, C., Wu, T. J. Biol. Chem. (2006)
- Two novel mutations of SURF1 in Leigh syndrome with cytochrome c oxidase deficiency. Teraoka, M., Yokoyama, Y., Ninomiya, S., Inoue, C., Yamashita, S., Seino, Y. Hum. Genet. (1999)
- Defects in cytochrome oxidase assembly in humans: lessons from yeast. Zee, J.M., Glerum, D.M. Biochem. Cell Biol. (2006)
- Maternal segmental disomy in Leigh syndrome with cytochrome c oxidase deficiency caused by homozygous SURF1 mutation. van Riesen, A.K., Antonicka, H., Ohlenbusch, A., Shoubridge, E.A., Wilichowski, E.K. Neuropediatrics. (2006)
- Evidence of COX-2 independent induction of apoptosis and cell cycle block in human colon carcinoma cells after S- or R-ibuprofen treatment. Janssen, A., Maier, T.J., Schiffmann, S., Coste, O., Seegel, M., Geisslinger, G., Grösch, S. Eur. J. Pharmacol. (2006)
- Mutant POLG2 disrupts DNA polymerase gamma subunits and causes progressive external ophthalmoplegia. Longley, M.J., Clark, S., Yu Wai Man, C., Hudson, G., Durham, S.E., Taylor, R.W., Nightingale, S., Turnbull, D.M., Copeland, W.C., Chinnery, P.F. Am. J. Hum. Genet. (2006)
- An mtDNA mutation in the initiation codon of the cytochrome C oxidase subunit II gene results in lower levels of the protein and a mitochondrial encephalomyopathy. Clark, K.M., Taylor, R.W., Johnson, M.A., Chinnery, P.F., Chrzanowska-Lightowlers, Z.M., Andrews, R.M., Nelson, I.P., Wood, N.W., Lamont, P.J., Hanna, M.G., Lightowlers, R.N., Turnbull, D.M. Am. J. Hum. Genet. (1999)
- Mutations in COX10 result in a defect in mitochondrial heme A biosynthesis and account for multiple, early-onset clinical phenotypes associated with isolated COX deficiency. Antonicka, H., Leary, S.C., Guercin, G.H., Agar, J.N., Horvath, R., Kennaway, N.G., Harding, C.O., Jaksch, M., Shoubridge, E.A. Hum. Mol. Genet. (2003)
- FOXP3+CD4+CD25+ adaptive regulatory T cells express cyclooxygenase-2 and suppress effector T cells by a prostaglandin E2-dependent mechanism. Mahic, M., Yaqub, S., Johansson, C.C., Taskén, K., Aandahl, E.M. J. Immunol. (2006)
- Carcinogen substrate specificity of human COX-1 and COX-2. Wiese, F.W., Thompson, P.A., Kadlubar, F.F. Carcinogenesis (2001)
- Impact of alkyl esters of caffeic and ferulic acids on tumor cell proliferation, cyclooxygenase enzyme, and lipid peroxidation. Jayaprakasam, B., Vanisree, M., Zhang, Y., Dewitt, D.L., Nair, M.G. J. Agric. Food Chem. (2006)
- m.6267G>A: a recurrent mutation in the human mitochondrial DNA that reduces cytochrome c oxidase activity and is associated with tumors. Gallardo, M.E., Moreno-Loshuertos, R., López, C., Casqueiro, M., Silva, J., Bonilla, F., Rodríguez de Córdoba, S., Enríquez, J.A. Hum. Mutat. (2006)
- Nitric oxide activates cyclooxygenase enzymes. Salvemini, D., Misko, T.P., Masferrer, J.L., Seibert, K., Currie, M.G., Needleman, P. Proc. Natl. Acad. Sci. U.S.A. (1993)
- Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Mitchell, J.A., Akarasereenont, P., Thiemermann, C., Flower, R.J., Vane, J.R. Proc. Natl. Acad. Sci. U.S.A. (1993)
- The structure of mammalian cyclooxygenases. Garavito, R.M., Mulichak, A.M. Annual review of biophysics and biomolecular structure. (2003)
- Role of COX-2, VEGF and cyclin D1 in mammary infiltrating duct carcinoma. Lim, S.C. Oncol. Rep. (2003)
- Novel sulfonanilide analogues suppress aromatase expression and activity in breast cancer cells independent of COX-2 inhibition. Su, B., Diaz-Cruz, E.S., Landini, S., Brueggemeier, R.W. J. Med. Chem. (2006)
- Non-steroidal anti-inflammatory drugs inhibit matrix metalloproteinase-2 expression via repression of transcription in lung cancer cells. Pan, M.R., Chuang, L.Y., Hung, W.C. FEBS Lett. (2001)
- Cyclooxygenase inhibitors modulate the p53/HDM2 pathway and enhance chemotherapy-induced apoptosis in neuroblastoma. Lau, L., Hansford, L.M., Cheng, L.S., Hang, M., Baruchel, S., Kaplan, D.R., Irwin, M.S. Oncogene (2007)
- Effects of the selective COX-2 inhibitors celecoxib and rofecoxib on human vascular cells. Niederberger, E., Manderscheid, C., Grösch, S., Schmidt, H., Ehnert, C., Geisslinger, G. Biochem. Pharmacol. (2004)
- Sulindac metabolites induce caspase- and proteasome-dependent degradation of beta-catenin protein in human colon cancer cells. Rice, P.L., Kelloff, J., Sullivan, H., Driggers, L.J., Beard, K.S., Kuwada, S., Piazza, G., Ahnen, D.J. Mol. Cancer Ther. (2003)
- Shy1p is necessary for full expression of mitochondrial COX1 in the yeast model of Leigh's syndrome. Barrientos, A., Korr, D., Tzagoloff, A. EMBO J. (2002)
- Chemistry and biology of anti-inflammatory marine natural products: molecules interfering with cyclooxygenase, NF-kappaB and other unidentified targets. Terracciano, S., Aquino, M., Rodriquez, M., Monti, M.C., Casapullo, A., Riccio, R., Gomez-Paloma, L. Current medicinal chemistry. (2006)
- Amino acid replacement is rapid in primates for the mature polypeptides of COX subunits, but not for their targeting presequences. Schmidt, T.R., Goodman, M., Grossman, L.I. Gene (2002)
- Dynamic compression counteracts IL-1beta induced iNOS and COX-2 activity by human chondrocytes cultured in agarose constructs. Chowdhury, T.T., Bader, D.L., Lee, D.A. Biorheology. (2006)
- 15-Hydroxyprostaglandin-dehydrogenase is involved in anti-proliferative effect of non-steroidal anti-inflammatory drugs COX-1 inhibitors on a human medullary thyroid carcinoma cell line. Quidville, V., Segond, N., Lausson, S., Frenkian, M., Cohen, R., Jullienne, A. Prostaglandins Other Lipid Mediat. (2006)
- COX-inhibitors relieve the immunosuppressive effect of tumor cells and improve functions of immune effectors. Lang, S., Picu, A., Hofmann, T., Andratschke, M., Mack, B., Moosmann, A., Gires, O., Tiwari, S., Zeidler, R. International journal of immunopathology and pharmacology. (2006)
- Characterization of SURF-1 expression and Surf-1p function in normal and disease conditions. Tiranti, V., Galimberti, C., Nijtmans, L., Bovolenta, S., Perini, M.P., Zeviani, M. Hum. Mol. Genet. (1999)
- Cytochrome c oxidase subunit I microdeletion in a patient with motor neuron disease. Comi, G.P., Bordoni, A., Salani, S., Franceschina, L., Sciacco, M., Prelle, A., Fortunato, F., Zeviani, M., Napoli, L., Bresolin, N., Moggio, M., Ausenda, C.D., Taanman, J.W., Scarlato, G. Ann. Neurol. (1998)
- Loss-of-function mutations of SURF-1 are specifically associated with Leigh syndrome with cytochrome c oxidase deficiency. Tiranti, V., Jaksch, M., Hofmann, S., Galimberti, C., Hoertnagel, K., Lulli, L., Freisinger, P., Bindoff, L., Gerbitz, K.D., Comi, G.P., Uziel, G., Zeviani, M., Meitinger, T. Ann. Neurol. (1999)