Gene Review:
HAND2 - heart and neural crest derivatives...
Homo sapiens
Synonyms:
BHLHA26, Class A basic helix-loop-helix protein 26, DHAND, DHAND2, Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2, ...
- HAND1 and HAND2 are expressed in the adult-rodent heart and are modulated during cardiac hypertrophy. Thattaliyath, B.D., Livi, C.B., Steinhelper, M.E., Toney, G.M., Firulli, A.B. Biochem. Biophys. Res. Commun. (2002)
- Modulation of basic helix-loop-helix transcription complex formation by Id proteins during neuronal differentiation. Jögi, A., Persson, P., Grynfeld, A., Påhlman, S., Axelson, H. J. Biol. Chem. (2002)
- Right and left go dHAND and eHAND. Overbeek, P.A. Nat. Genet. (1997)
- Three-dimensional structure of recoverin, a calcium sensor in vision. Flaherty, K.M., Zozulya, S., Stryer, L., McKay, D.B. Cell (1993)
- The bHLH transcription factor hand2 is essential for noradrenergic differentiation of sympathetic neurons. Lucas, M.E., M??ller, F., R??diger, R., Henion, P.D., Rohrer, H. Development (2006)
- Tbx3 can alter limb position along the rostrocaudal axis of the developing embryo. Rallis, C., Del Buono, J., Logan, M.P. Development (2005)
- HAND2 synergistically enhances transcription of dopamine-beta-hydroxylase in the presence of Phox2a. Xu, H., Firulli, A.B., Zhang, X., Howard, M.J. Dev. Biol. (2003)
- Genetic and comparative mapping of genes dysregulated in mouse hearts lacking the Hand2 transcription factor gene. Villanueva, M.P., Aiyer, A.R., Muller, S., Pletcher, M.T., Liu, X., Emanuel, B., Srivastava, D., Reeves, R.H. Genomics (2002)
- Molecular cloning of the human HAND2 gene. Russell, M.W., Kemp, P., Wang, L., Brody, L.C., Izumo, S. Biochim. Biophys. Acta (1998)
- The basic helix-loop-helix factor, HAND2, functions as a transcriptional activator by binding to E-boxes as a heterodimer. Dai, Y.S., Cserjesi, P. J. Biol. Chem. (2002)
- Transcripts encoding HAND genes are differentially expressed and regulated by BMP4 and GDNF in developing avian gut. Wu, X., Howard, M.J. Gene Expr. (2002)
- The transcription factors GATA4 and dHAND physically interact to synergistically activate cardiac gene expression through a p300-dependent mechanism. Dai, Y.S., Cserjesi, P., Markham, B.E., Molkentin, J.D. J. Biol. Chem. (2002)
- Regulation of dHAND protein expression by all-trans retinoic acid through ET-1/ETAR signaling in H9c2 cells. Li, W., Li, Y. J. Cell. Biochem. (2006)
- Cooperative activation of atrial naturetic peptide promoter by dHAND and MEF2C. Zang, M.X., Li, Y., Xue, L.X., Jia, H.T., Jing, H. J. Cell. Biochem. (2004)
- The interaction between dHAND and Arix at the dopamine beta-hydroxylase promoter region is independent of direct dHAND binding to DNA. Rychlik, J.L., Gerbasi, V., Lewis, E.J. J. Biol. Chem. (2003)
- PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation. Firulli, B.A., Howard, M.J., McDaid, J.R., McIlreavey, L., Dionne, K.M., Centonze, V.E., Cserjesi, P., Virshup, D.M., Firulli, A.B. Mol. Cell (2003)
- Interstitial deletion of 10p and atrial septal defect in DiGeorge 2 syndrome. Yatsenko, S.A., Yatsenko, A.N., Szigeti, K., Craigen, W.J., Stankiewicz, P., Cheung, S.W., Lupski, J.R. Clin. Genet. (2004)
- MEF2-dependent recruitment of the HAND1 transcription factor results in synergistic activation of target promoters. Morin, S., Pozzulo, G., Robitaille, L., Cross, J., Nemer, M. J. Biol. Chem. (2005)
- Phox2 and dHAND transcription factors select shared and unique target genes in the noradrenergic cell type. Rychlik, J.L., Hsieh, M., Eiden, L.E., Lewis, E.J. J. Mol. Neurosci. (2005)
- Human eHAND, but not dHAND, is down-regulated in cardiomyopathies. Natarajan, A., Yamagishi, H., Ahmad, F., Li, D., Roberts, R., Matsuoka, R., Hill, S., Srivastava, D. J. Mol. Cell. Cardiol. (2001)