Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene: cheA - fused chemotactic sensory histidine kinase...

Escherichia coli str. K12 substr. MG1655

Synonyms: ECK1889, JW1877

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Ward, M.J., Oosawa, K., Wu, M., Kunst, F., Rowsell, E.H., et al.

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Disease relevance of cheA

A mutant with an interrupted copy of cheA showed normal patterns of swimming, unlike the equivalent mutants in E. coli which are smooth swimming [1].

Psychiatry related information on cheA

The unusual behaviour of the cheA mutant and the identification of two homologues of cheY suggests that R. sphaeroides has at least two pathways controlling motor activity [1].

High impact information on cheA

To examine the correlation between CheA phosphorylation and bacterial chemotaxis, cheA mutations leading to defects in chemotaxis were mapped and characterized [2].
Furthermore, the mutant phenotypes were found to cluster in different regions of the cheA gene [2].
We found that chemotaxis in the cheW Che+ suppressor depended on both cheY and cheA [3].
The 3D trajectories were generated for wild-type Escherichia coli strain RP437 as well as for isogenic derivatives that display smooth swimming due to a cheA deletion (strain RP9535) or incessant tumbling behavior due to a cheZ deletion (strain RP1616) [4].
Thus, we conclude that both the methylation-independent and methylation-dependent pathways converge at CheA, the histidine kinase product of cheA [5].

Biological context of cheA

Open reading frame 1 encodes a 45,000-dalton polypeptide that is similar to the products of the Salmonella typhimurium cheA and Escherichia coli cpxA genes, which act as sensory transducers [6].

References

Identification of a chemotaxis operon with two cheY genes in Rhodobacter sphaeroides. Ward, M.J., Bell, A.W., Hamblin, P.A., Packer, H.L., Armitage, J.P. Mol. Microbiol. (1995)
Mutants defective in bacterial chemotaxis show modified protein phosphorylation. Oosawa, K., Hess, J.F., Simon, M.I. Cell (1988)
Proteomic mapping of a suppressor of non-chemotactic cheW mutants reveals that Helicobacter pylori contains a new chemotaxis protein. Terry, K., Go, A.C., Ottemann, K.M. Mol. Microbiol. (2006)
Collective bacterial dynamics revealed using a three-dimensional population-scale defocused particle tracking technique. Wu, M., Roberts, J.W., Kim, S., Koch, D.L., DeLisa, M.P. Appl. Environ. Microbiol. (2006)
CheA, CheW, and CheY are required for chemotaxis to oxygen and sugars of the phosphotransferase system in Escherichia coli. Rowsell, E.H., Smith, J.M., Wolfe, A., Taylor, B.L. J. Bacteriol. (1995)
Deduced polypeptides encoded by the Bacillus subtilis sacU locus share homology with two-component sensor-regulator systems. Kunst, F., Debarbouille, M., Msadek, T., Young, M., Mauel, C., Karamata, D., Klier, A., Rapoport, G., Dedonder, R. J. Bacteriol. (1988)