Gene Review:
CD36 - CD36 molecule (thrombospondin receptor)
Homo sapiens
Synonyms:
BDPLT10, CHDS7, FAT, Fatty acid translocase, GP3B, ...
Kuriki,
Chiba,
Saito,
Kanemitsu,
Hamajima,
Hirai,
Matsuo,
Tajima,
Tokudome,
Koike,
Kato,
Primo,
Marchiò,
Bussolino,
di Blasio,
Alessio,
Ferrandi,
Roca,
Yuqian Luo,
Bonen,
Glatz,
Heigenhauser,
Tandon,
Dyck,
Parolin,
Steinberg,
Luiken,
Calles-Escandon,
Marta Ramirez Gaite,
Ricciarelli,
Pronzato,
Zingg,
Tabaton,
Giliberto,
D'Abramo,
Marinari,
Markesbery,
Azzi,
- PECAM-1/CD31, an endothelial receptor for binding Plasmodium falciparum-infected erythrocytes. Treutiger, C.J., Heddini, A., Fernandez, V., Muller, W.A., Wahlgren, M. Nat. Med. (1997)
- Identification of a CD36-related thrombospondin 1-binding domain in HIV-1 envelope glycoprotein gp120: relationship to HIV-1-specific inhibitory factors in human saliva. Crombie, R., Silverstein, R.L., MacLow, C., Pearce, S.F., Nachman, R.L., Laurence, J. J. Exp. Med. (1998)
- CD36 polymorphism is associated with protection from cerebral malaria. Omi, K., Ohashi, J., Patarapotikul, J., Hananantachai, H., Naka, I., Looareesuwan, S., Tokunaga, K. Am. J. Hum. Genet. (2003)
- CD36 associates with CD9 and integrins on human blood platelets. Miao, W.M., Vasile, E., Lane, W.S., Lawler, J. Blood (2001)
- Differential roles of protein kinase C and pertussis toxin-sensitive G-binding proteins in modulation of melanoma cell proliferation and motility by thrombospondin 1. Guo, N., Zabrenetzky, V.S., Chandrasekaran, L., Sipes, J.M., Lawler, J., Krutzsch, H.C., Roberts, D.D. Cancer Res. (1998)
- CD36 overexpression in human brain correlates with beta-amyloid deposition but not with Alzheimer's disease. Ricciarelli, R., D'Abramo, C., Zingg, J.M., Giliberto, L., Markesbery, W., Azzi, A., Marinari, U.M., Pronzato, M.A., Tabaton, M. Free Radic. Biol. Med. (2004)
- Relation of the CD36 gene A52C polymorphism to the risk of colorectal cancer among Japanese, with reference to with the aldehyde dehydrogenase 2 gene Glu487Lys polymorphism and drinking habit. Kuriki, K., Hamajima, N., Chiba, H., Kanemitsu, Y., Hirai, T., Kato, T., Saito, T., Matsuo, K., Koike, K., Tokudome, S., Tajima, K. Asian Pac. J. Cancer Prev. (2005)
- Circulating activated endothelial cells in sickle cell anemia. Solovey, A., Lin, Y., Browne, P., Choong, S., Wayner, E., Hebbel, R.P. N. Engl. J. Med. (1997)
- Cloning the P. falciparum gene encoding PfEMP1, a malarial variant antigen and adherence receptor on the surface of parasitized human erythrocytes. Baruch, D.I., Pasloske, B.L., Singh, H.B., Bi, X., Ma, X.C., Feldman, M., Taraschi, T.F., Howard, R.J. Cell (1995)
- CD36 directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Oquendo, P., Hundt, E., Lawler, J., Seed, B. Cell (1989)
- A link between diabetes and atherosclerosis: Glucose regulates expression of CD36 at the level of translation. Griffin, E., Re, A., Hamel, N., Fu, C., Bush, H., McCaffrey, T., Asch, A.S. Nat. Med. (2001)
- CD36 deficiency induced by antiretroviral therapy. Serghides, L., Nathoo, S., Walmsley, S., Kain, K.C. AIDS (2002)
- Surface expression of fatty acid translocase (FAT/CD36) on platelets in myeloproliferative disorders and non-insulin dependent diabetes mellitus: effect on arachidonic acid uptake. Salah-Uddin, H., Gordon, M.J., Ford, I., Tandon, N.N., Greaves, M., Duttaroy, A.K. Mol. Cell. Biochem. (2002)
- Estradiol down-regulates CD36 expression in human breast cancer cells. Uray, I.P., Liang, Y., Hyder, S.M. Cancer Lett. (2004)
- Modulators of intraplatelet calcium concentration affect the binding of thrombospondin to blood platelets in healthy donors and patients with type 2 diabetes mellitus. Wieclawska, B., Rozalski, M., Trojanowski, Z., Watala, C. Eur. J. Haematol. (2001)
- Triacylglycerol accumulation in human obesity and type 2 diabetes is associated with increased rates of skeletal muscle fatty acid transport and increased sarcolemmal FAT/CD36. Bonen, A., Parolin, M.L., Steinberg, G.R., Calles-Escandon, J., Tandon, N.N., Glatz, J.F., Luiken, J.J., Heigenhauser, G.J., Dyck, D.J. FASEB J. (2004)
- Thrombospondin cooperates with CD36 and the vitronectin receptor in macrophage recognition of neutrophils undergoing apoptosis. Savill, J., Hogg, N., Ren, Y., Haslett, C. J. Clin. Invest. (1992)
- Molecular basis of CD36 deficiency. Evidence that a 478C-->T substitution (proline90-->serine) in CD36 cDNA accounts for CD36 deficiency. Kashiwagi, H., Tomiyama, Y., Honda, S., Kosugi, S., Shiraga, M., Nagao, N., Sekiguchi, S., Kanayama, Y., Kurata, Y., Matsuzawa, Y. J. Clin. Invest. (1995)
- Translocation of the Csk homologous kinase (Chk/Hyl) controls activity of CD36-anchored Lyn tyrosine kinase in thrombin-stimulated platelets. Hirao, A., Hamaguchi, I., Suda, T., Yamaguchi, N. EMBO J. (1997)
- CD36 mediates the In vitro inhibitory effects of thrombospondin-1 on endothelial cells. Dawson, D.W., Pearce, S.F., Zhong, R., Silverstein, R.L., Frazier, W.A., Bouck, N.P. J. Cell Biol. (1997)
- Phenotype analysis of hematopoietic CD34+ cell populations derived from human umbilical cord blood using flow cytometry and cDNA-polymerase chain reaction. Thoma, S.J., Lamping, C.P., Ziegler, B.L. Blood (1994)
- Plasmodium falciparum erythrocyte membrane protein 1 is a parasitized erythrocyte receptor for adherence to CD36, thrombospondin, and intercellular adhesion molecule 1. Baruch, D.I., Gormely, J.A., Ma, C., Howard, R.J., Pasloske, B.L. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Identification of a novel family of oxidized phospholipids that serve as ligands for the macrophage scavenger receptor CD36. Podrez, E.A., Poliakov, E., Shen, Z., Zhang, R., Deng, Y., Sun, M., Finton, P.J., Shan, L., Gugiu, B., Fox, P.L., Hoff, H.F., Salomon, R.G., Hazen, S.L. J. Biol. Chem. (2002)
- Thrombospondin-1 inhibits nitric oxide signaling via CD36 by inhibiting myristic acid uptake. Isenberg, J.S., Jia, Y., Fukuyama, J., Switzer, C.H., Wink, D.A., Roberts, D.D. J. Biol. Chem. (2007)
- Opposite regulation of CD36 ubiquitination by fatty acids and insulin: effects on fatty acid uptake. Smith, J., Su, X., El-Maghrabi, R., Stahl, P.D., Abumrad, N.A. J. Biol. Chem. (2008)
- Thrombospondin binds normally to glycoprotein IIIb deficient platelets. Kehrel, B., Kronenberg, A., Schwippert, B., Niesing-Bresch, D., Niehues, U., Tschöpe, D., van de Loo, J., Clemetson, K.J. Biochem. Biophys. Res. Commun. (1991)
- Long-chain fatty acid uptake and FAT/CD36 translocation in heart and skeletal muscle. Koonen, D.P., Glatz, J.F., Bonen, A., Luiken, J.J. Biochim. Biophys. Acta (2005)
- Receptor-specific adhesion and clinical disease in Plasmodium falciparum. Newbold, C., Warn, P., Black, G., Berendt, A., Craig, A., Snow, B., Msobo, M., Peshu, N., Marsh, K. Am. J. Trop. Med. Hyg. (1997)
- Human dermal microvascular endothelial but not human umbilical vein endothelial cells express CD36 in vivo and in vitro. Swerlick, R.A., Lee, K.H., Wick, T.M., Lawley, T.J. J. Immunol. (1992)
- Sarcolemmal FAT/CD36 in human skeletal muscle colocalizes with caveolin-3 and is more abundant in type 1 than in type 2 fibers. Vistisen, B., Roepstorff, K., Roepstorff, C., Bonen, A., van Deurs, B., Kiens, B. J. Lipid Res. (2004)
- Identification of CD36 molecular features required for its in vitro angiostatic activity. Primo, L., Ferrandi, C., Roca, C., Marchiò, S., di Blasio, L., Alessio, M., Bussolino, F. FASEB J. (2005)
- Retinoids potentiate peroxisome proliferator-activated receptor gamma action in differentiation, gene expression, and lipid metabolic processes in developing myeloid cells. Szanto, A., Nagy, L. Mol. Pharmacol. (2005)
- Immunohistochemical properties of the endothelial cells in the human uterus during the menstrual cycle. Rees, M.C., Heryet, A.R., Bicknell, R. Hum. Reprod. (1993)
- Thrombin-stimulated calcium mobilization is inhibited by thrombospondin via CD36. Enenstein, J., Gupta, K., Vercellotti, G.M., Hebbel, R.P. Exp. Cell Res. (1998)
- Glycoprotein VI is a major collagen receptor for platelet activation: it recognizes the platelet-activating quaternary structure of collagen, whereas CD36, glycoprotein IIb/IIIa, and von Willebrand factor do not. Kehrel, B., Wierwille, S., Clemetson, K.J., Anders, O., Steiner, M., Knight, C.G., Farndale, R.W., Okuma, M., Barnes, M.J. Blood (1998)
- Expression of lymphoid-associated cell surface antigens by childhood acute myeloid leukemia cells lacks prognostic significance. Smith, F.O., Lampkin, B.C., Versteeg, C., Flowers, D.A., Dinndorf, P.A., Buckley, J.D., Woods, W.G., Hammond, G.D., Bernstein, I.D. Blood (1992)
- Characterization of phosphatidylserine-dependent beta2-glycoprotein I macrophage interactions. Implications for apoptotic cell clearance by phagocytes. Balasubramanian, K., Schroit, A.J. J. Biol. Chem. (1998)
- Human immunodeficiency virus-associated oral Kaposi's sarcoma. A heterogeneous cell population dominated by spindle-shaped endothelial cells. Regezi, J.A., MacPhail, L.A., Daniels, T.E., DeSouza, Y.G., Greenspan, J.S., Greenspan, D. Am. J. Pathol. (1993)
- Mycobacterium leprae intracellular survival relies on cholesterol accumulation in infected macrophages: a potential target for new drugs for leprosy treatment. Mattos, K.A., Oliveira, V.C., Berrêdo-Pinho, M., Amaral, J.J., Antunes, L.C., Melo, R.C., Acosta, C.C., Moura, D.F., Olmo, R., Han, J., Rosa, P.S., Almeida, P.E., Finlay, B.B., Borchers, C.H., Sarno, E.N., Bozza, P.T., Atella, G.C., Pessolani, M.C. Cell. Microbiol. (2014)
- Fatty acid translocase (FAT/CD36) is localized on insulin-containing granules in human pancreatic beta-cells and mediates fatty acid effects on insulin secretion. Noushmehr, H., D'Amico, E., Farilla, L., Hui, H., Wawrowsky, K.A., Mlynarski, W., Doria, A., Abumrad, N.A., Perfetti, R. Diabetes (2005)
- Macrophage recognition and phagocytosis of apoptotic fibroblasts is critically dependent on fibroblast-derived thrombospondin 1 and CD36. Moodley, Y., Rigby, P., Bundell, C., Bunt, S., Hayashi, H., Misso, N., McAnulty, R., Laurent, G., Scaffidi, A., Thompson, P., Knight, D. Am. J. Pathol. (2003)
- Structural organization of the gene for human CD36 glycoprotein. Armesilla, A.L., Vega, M.A. J. Biol. Chem. (1994)