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BAG3  -  BCL2-associated athanogene 3

Homo sapiens

Synonyms: BAG family molecular chaperone regulator 3, BAG-3, BIS, Bcl-2-associated athanogene 3, Bcl-2-binding protein Bis, ...
 
 
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Disease relevance of BAG3

  • The expression of CAIR-1, CAI stressed-1, was induced in A2058 human melanoma cells by continuous exposure to CAI, an inhibitor of nonvoltage-gated calcium influx [1].
  • Evidence for BAG3 modulation of HIV-1 gene transcription [2].
  • BAG3 deficiency results in fulminant myopathy and early lethality [3].
  • BAG3 protein regulates cell survival in childhood acute lymphoblastic leukemia cells [4].
  • Human breast cancer cells were engineered to overexpress either full-length CAIR-1 (FL), which binds Hsp70, or a BAG domain-deletion mutant (dBAG) that cannot bind Hsp70 [5].
  • The protein was not detectable in 19 of 20 specimens of normal thyroid or goiters, whereas 54 of 56 analyzed carcinomas (15 follicular, 28 papillary, and 13 anaplastic) were clearly positive for BAG3 expression [6].
 

Psychiatry related information on BAG3

  • Patients were rated on Hopkins Symptoms Checklist 90 (SCL-90), Brief Psychiatric Rating Scale (BPRS), Global Assessment of Function (GAF), Barratt Impulsivity Scale (BIS 11), and Buss-Durkee Hostility Inventory (BDHI) [7].
  • This study evaluated the use of the Bispectral Index (BIS monitor), the University of Michigan Sedation Scale (UMSS; i.e., 0-4 observational scale), and a Modified Maintenance of Wakefulness Test (MMWT; visual observation of the time the child is able to stay awake) in assessing return to baseline status [8].
  • Consistent with Gray's biological model of the behavioral inhibition system (BIS), children with both CD and anxiety disorder had higher levels of salivary cortisol than children with CD without comorbid anxiety disorder [9].
  • This study had two objectives: To examine poorly understood patterns of young children's electrodermal reactivity and to test the hypothesis that this reactivity reflects individual differences in the behavioral inhibition system (BIS) [10].
  • The objective of this study was to evaluate hippocampally based recognition memory and infant development in IDMs with suspected brain iron deficiency (BID; cord ferritin </=34 microg/L) compared with IDMs with sufficient brain iron stores (BIS; cord ferritin >34 microg/L) using event-related potentials (ERPs) [11].
 

High impact information on BAG3

 

Chemical compound and disease context of BAG3

 

Biological context of BAG3

  • The Ciona genome encodes 3 types of BAG family proteins, all of which have human and protostome counterparts (BAG1, BAG3, and BAT3) [18].
  • These observations reveal a previously unrecognized cell response, that is, an increase in BAG3, elicited by HIV-1 infection, and may provide a new avenue for the suppression of HIV-1 gene expression [2].
  • In HeLa cells the expression of the BAG-3 gene, a member of the BAG family, is regulated by heavy metals and temperature, with kinetics of accumulation of mRNAs similar to Hsp70 and metallothioneins [19].
  • Because stress and survival pathways are active during invasion and metastasis, we hypothesized that CAIR-1 is a regulator of signaling pathways that modulate cell adhesion and migration [20].
  • Single-frequency bioelectrical-impedance analyses (BIA) and bioelectrical spectroscopy (modeling multifrequency measurements; BIS) were validated as methods to predict body water (BW) compartments in 29 healthy adults [21].
 

Anatomical context of BAG3

 

Associations of BAG3 with chemical compounds

  • Ubiquitinated Akt accumulated in FL-expressing cells, mimicking the effect of lactacystin proteasomal inhibition, indicating that CAIR-1 inhibits proteasomal degradation distal to protein ubiquitination in a BAG domain-dependent manner [5].
  • This study was designed to evaluate the predictive performance of spectral edge frequency 95 (SEF95), BIS, and approximate entropy for the response to increasingly intense stimuli under different concentrations of both propofol and remifentanil in the therapeutic range [24].
  • The relation among BIS, 95% SEF, MPF, sevoflurane concentration, sedation score, and movement or no movement after skin incision, was determined [25].
  • The prediction probability (PK) was calculated for the BIS and the Narcotrend index to predict isoflurane effect compartment concentration for each measure [26].
  • In this randomized, crossover, placebo-controlled clinical trial, we characterized the effects of oral clonidine pre-treatment on intravenous diazepam/meperidine sedation using the bi-spectral index (BIS) in 13 participants [14].
 

Physical interactions of BAG3

  • PLC-gamma is bound to CAIR-1/BAG-3 in unstimulated cells [1].
  • These findings suggest that Hsp70 is a chaperone driving a multiprotein degradation complex and that the inhibitory co-chaperone CAIR-1 functions distal to client ubiquitination [5].
  • CAIR-1/BAG-3 is a stress and survival protein that has been shown to bind SH3 domain-containing proteins through its proline-rich (PXXP) domain [20].
 

Other interactions of BAG3

 

Analytical, diagnostic and therapeutic context of BAG3

References

  1. CAIR-1/BAG-3 forms an EGF-regulated ternary complex with phospholipase C-gamma and Hsp70/Hsc70. Doong, H., Price, J., Kim, Y.S., Gasbarre, C., Probst, J., Liotta, L.A., Blanchette, J., Rizzo, K., Kohn, E. Oncogene (2000) [Pubmed]
  2. Evidence for BAG3 modulation of HIV-1 gene transcription. Rosati, A., Leone, A., Del Valle, L., Amini, S., Khalili, K., Turco, M.C. J. Cell. Physiol. (2007) [Pubmed]
  3. BAG3 deficiency results in fulminant myopathy and early lethality. Homma, S., Iwasaki, M., Shelton, G.D., Engvall, E., Reed, J.C., Takayama, S. Am. J. Pathol. (2006) [Pubmed]
  4. BAG3 protein regulates cell survival in childhood acute lymphoblastic leukemia cells. Romano, M.F., Festa, M., Petrella, A., Rosati, A., Pascale, M., Bisogni, R., Poggi, V., Kohn, E.C., Venuta, S., Turco, M.C., Leone, A. Cancer Biol. Ther. (2003) [Pubmed]
  5. CAIR-1/BAG-3 abrogates heat shock protein-70 chaperone complex-mediated protein degradation: accumulation of poly-ubiquitinated Hsp90 client proteins. Doong, H., Rizzo, K., Fang, S., Kulpa, V., Weissman, A.M., Kohn, E.C. J. Biol. Chem. (2003) [Pubmed]
  6. The antiapoptotic protein BAG3 is expressed in thyroid carcinomas and modulates apoptosis mediated by tumor necrosis factor-related apoptosis-inducing ligand. Chiappetta, G., Ammirante, M., Basile, A., Rosati, A., Festa, M., Monaco, M., Vuttariello, E., Pasquinelli, R., Arra, C., Zerilli, M., Todaro, M., Stassi, G., Pezzullo, L., Gentilella, A., Tosco, A., Pascale, M., Marzullo, L., Belisario, M.A., Turco, M.C., Leone, A. J. Clin. Endocrinol. Metab. (2007) [Pubmed]
  7. Olanzapine safety and efficacy in patients with borderline personality disorder and comorbid dysthymia. Schulz, S.C., Camlin, K.L., Berry, S.A., Jesberger, J.A. Biol. Psychiatry (1999) [Pubmed]
  8. Can we improve the assessment of discharge readiness?: A comparative study of observational and objective measures of depth of sedation in children. Malviya, S., Voepel-Lewis, T., Ludomirsky, A., Marshall, J., Tait, A.R. Anesthesiology (2004) [Pubmed]
  9. Anxiety, inhibition, and conduct disorder in children: II. Relation to salivary cortisol. McBurnett, K., Lahey, B.B., Frick, P.J., Risch, C., Loeber, R., Hart, E.L., Christ, M.A., Hanson, K.S. Journal of the American Academy of Child and Adolescent Psychiatry. (1991) [Pubmed]
  10. Electrodermal activity and temperament in preschool children. Fowles, D.C., Kochanska, G., Murray, K. Psychophysiology. (2000) [Pubmed]
  11. Iron deficiency alters auditory recognition memory in newborn infants of diabetic mothers. Siddappa, A.M., Georgieff, M.K., Wewerka, S., Worwa, C., Nelson, C.A., Deregnier, R.A. Pediatr. Res. (2004) [Pubmed]
  12. BAG3 protein controls B-chronic lymphocytic leukaemia cell apoptosis. Romano, M.F., Festa, M., Pagliuca, G., Lerose, R., Bisogni, R., Chiurazzi, F., Storti, G., Volpe, S., Venuta, S., Turco, M.C., Leone, A. Cell Death Differ. (2003) [Pubmed]
  13. Tumor-targeted apoptosis by a novel spermine analogue, 1,12-diaziridinyl-4,9-diazadodecane, results in therapeutic efficacy and enhanced radiosensitivity of human prostate cancer. Eiseman, J.L., Rogers, F.A., Guo, Y., Kauffman, J., Sentz, D.L., Klinger, M.F., Callery, P.S., Kyprianou, N. Cancer Res. (1998) [Pubmed]
  14. Oral Clonidine Pre-treatment and Diazepam/Meperidine Sedation. Hall, D.L., Tatakis, D.N., Walters, J.D., Rezvan, E. J. Dent. Res. (2006) [Pubmed]
  15. BIS during etomidate-induced myoclonus. Lim, T.A., Lim, K.Y. Anaesthesia. (2006) [Pubmed]
  16. Time-frequency balanced spectral entropy as a measure of anesthetic drug effect in central nervous system during sevoflurane, propofol, and thiopental anesthesia. Vakkuri, A., Yli-Hankala, A., Talja, P., Mustola, S., Tolvanen-Laakso, H., Sampson, T., Viertiö-Oja, H. Acta anaesthesiologica Scandinavica. (2004) [Pubmed]
  17. Intraoperative wake-up test in neonatal neurosurgery. Govindarajan, R., Babalola, O., Gad-El-Kareem, M., Kodali, N.S., Aronson, J., Abadir, A. Paediatric anaesthesia. (2006) [Pubmed]
  18. A genomewide analysis of genes for the heat shock protein 70 chaperone system in the ascidian Ciona intestinalis. Wada, S., Hamada, M., Satoh, N. Cell Stress Chaperones (2006) [Pubmed]
  19. Regulation by heavy metals and temperature of the human BAG-3 gene, a modulator of Hsp70 activity. Pagliuca, M.G., Lerose, R., Cigliano, S., Leone, A. FEBS Lett. (2003) [Pubmed]
  20. CAIR-1/BAG-3 modulates cell adhesion and migration by downregulating activity of focal adhesion proteins. Kassis, J.N., Guancial, E.A., Doong, H., Virador, V., Kohn, E.C. Exp. Cell Res. (2006) [Pubmed]
  21. Validation of bioelectrical-impedance measurements as a method to estimate body-water compartments. van Marken Lichtenbelt, W.D., Westerterp, K.R., Wouters, L., Luijendijk, S.C. Am. J. Clin. Nutr. (1994) [Pubmed]
  22. BAG3 protein regulates stress-induced apoptosis in normal and neoplastic leukocytes. Bonelli, P., Petrella, A., Rosati, A., Romano, M.F., Lerose, R., Pagliuca, M.G., Amelio, T., Festa, M., Martire, G., Venuta, S., Turco, M.C., Leone, A. Leukemia (2004) [Pubmed]
  23. The anti-apoptotic protein BAG-3 is overexpressed in pancreatic cancer and induced by heat stress in pancreatic cancer cell lines. Liao, Q., Ozawa, F., Friess, H., Zimmermann, A., Takayama, S., Reed, J.C., Kleeff, J., Büchler, M.W. FEBS Lett. (2001) [Pubmed]
  24. Correlation of approximate entropy, bispectral index, and spectral edge frequency 95 (SEF95) with clinical signs of "anesthetic depth" during coadministration of propofol and remifentanil. Bruhn, J., Bouillon, T.W., Radulescu, L., Hoeft, A., Bertaccini, E., Shafer, S.L. Anesthesiology (2003) [Pubmed]
  25. Electroencephalographic derivatives as a tool for predicting the depth of sedation and anesthesia induced by sevoflurane. Katoh, T., Suzuki, A., Ikeda, K. Anesthesiology (1998) [Pubmed]
  26. Application of Bispectral Index and Narcotrend index to the measurement of the electroencephalographic effects of isoflurane with and without burst suppression. Kreuer, S., Bruhn, J., Larsen, R., Grundmann, U., Shafer, S.L., Wilhelm, W. Anesthesiology (2004) [Pubmed]
  27. What's in the 'BAG'?--A functional domain analysis of the BAG-family proteins. Doong, H., Vrailas, A., Kohn, E.C. Cancer Lett. (2002) [Pubmed]
  28. Novel partner proteins of adenovirus penton. Chroboczek, J., Gout, E., Favier, A.L., Galinier, R. Curr. Top. Microbiol. Immunol. (2003) [Pubmed]
  29. BIS monitoring to prevent awareness during general anesthesia. O'Connor, M.F., Daves, S.M., Tung, A., Cook, R.I., Thisted, R., Apfelbaum, J. Anesthesiology (2001) [Pubmed]
 
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