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Gene Review: 

VPS26A  -  vacuolar protein sorting 26 homolog A (S....

Homo sapiens

Synonyms: FLJ12930, HB58, Hbeta58, hVPS26, PEP8A, ...
 
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High impact information on VPS26A

  • VPS35 is the core molecule of the retromer trafficking complex and further analysis revealed that VPS26, another member of the complex, is also downregulated in AD [1].
  • Identification and characterization of a novel, evolutionarily conserved gene disrupted by the murine H beta 58 embryonic lethal transgene insertion [2].
  • The wild-type H beta 58 gene encodes a single 2.7 kb mRNA during embryonic and fetal development, and in many adult somatic tissues [2].
  • 5. In this paper, we describe the characterization of a novel gene encoded at the H beta 58 locus, whose disruption appears to be responsible for the mutant phenotype [2].
  • A similar change of memapsin 2 localization also was observed when a retromer subunit, VPS26, was depleted [3].
 

Biological context of VPS26A

 

Anatomical context of VPS26A

  • The loop is phylogenetically conserved and provides a mechanism for Vps26 integration into the complex that leaves the rest of the structure free for engagements with membranes and for conformational changes [5].
 

Associations of VPS26A with chemical compounds

  • Hydrophobic residues and a glycine in this loop are required for integration into the retromer complex and endosomal localization of human Vps26, and for the function of yeast Vps26 in carboxypeptidase Y sorting [5].
 

Analytical, diagnostic and therapeutic context of VPS26A

  • Sequence analysis of H beta 58 cDNA clones revealed no homology between the 38 x 10(3) M(r) H beta 58 protein and other known proteins [2].

References

  1. Model-guided microarray implicates the retromer complex in Alzheimer's disease. Small, S.A., Kent, K., Pierce, A., Leung, C., Kang, M.S., Okada, H., Honig, L., Vonsattel, J.P., Kim, T.W. Ann. Neurol. (2005)
  2. Identification and characterization of a novel, evolutionarily conserved gene disrupted by the murine H beta 58 embryonic lethal transgene insertion. Lee, J.J., Radice, G., Perkins, C.P., Costantini, F. Development (1992)
  3. GGA proteins mediate the recycling pathway of memapsin 2 (BACE). He, X., Li, F., Chang, W.P., Tang, J. J. Biol. Chem. (2005)
  4. Isolation of a novel human gene from the Down syndrome critical region of chromosome 21q22.2. Nakamura, A., Hattori, M., Sakaki, Y. J. Biochem. (1997)
  5. The retromer subunit Vps26 has an arrestin fold and binds Vps35 through its C-terminal domain. Shi, H., Rojas, R., Bonifacino, J.S., Hurley, J.H. Nat. Struct. Mol. Biol. (2006)
 

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