Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

NA - neuraminidase

Influenza A virus (A/Puerto Rico/8/1934(H1N1))

Fields, S. et al., Schrader, C. et al., Blok, J. et al., Gibbs, M.J. et al., Blok, J. et al.

Gibbs, Armstrong, Gibbs, Schrader, Süss,

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Disease relevance of NA

Structure of the neuraminidase gene in human influenza virus A/PR/8/34 [1].
The complete structure of the neuraminidase gene in influenza A/PR/8/34 has been determined by cloning into the bacteriophage M13 and sequencing with dideoxynucleotide chain terminators [1].
Block deletions in the neuraminidase genes from some influenza A viruses of the N1 subtype [2].

High impact information on NA

The haemagglutinin gene, but not the neuraminidase gene, of 'Spanish flu' was a recombinant [3].
Comparative nucleotide sequences at the 3' end of the neuraminidase gene from eleven influenza type A viruses [4].

Analytical, diagnostic and therapeutic context of NA

Sequence analysis of hemagglutinin, neuraminidase and matrix genes indicated that this virus is a reassortant of human H1N1 and human H3N2 strains with an internal gene, the M gene of avian origin [5].

References

Structure of the neuraminidase gene in human influenza virus A/PR/8/34. Fields, S., Winter, G., Brownlee, G.G. Nature (1981) [Pubmed]
Block deletions in the neuraminidase genes from some influenza A viruses of the N1 subtype. Blok, J., Air, G.M. Virology (1982) [Pubmed]
The haemagglutinin gene, but not the neuraminidase gene, of 'Spanish flu' was a recombinant. Gibbs, M.J., Armstrong, J.S., Gibbs, A.J. Philos. Trans. R. Soc. Lond., B, Biol. Sci. (2001) [Pubmed]
Comparative nucleotide sequences at the 3' end of the neuraminidase gene from eleven influenza type A viruses. Blok, J., Air, G.M. Virology (1980) [Pubmed]
Genetic characterization of a porcine H1N2 influenza virus strain isolated in Germany. Schrader, C., Süss, J. Intervirology (2003) [Pubmed]

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