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Gene Review

terC  -  phage inhibition, colicin resistance and...

Escherichia coli O157:H7 str. EDL933

 
 
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Disease relevance of terC

  • To confirm the replicative mechanism, we have also used the Escherichia coli terminators (terC) which, when bound by the Tus protein, inhibit replication forks in a polarised manner [1].
  • We have circumvented this problem in the characterization and fine mapping of the origin of plasmid pAM beta 1 by exploiting the Bacillus subtilis termination signal, terC [2].
  • A region of SP beta homology distinct from the prophage and just to the left of terC was identified [3].
 

High impact information on terC

  • Overexpression of mutant forms of MreB inhibited cell division, caused abnormal MreB filament morphology and induced severe localization defects of the nucleoid and of the oriC and terC chromosomal regions [4].
  • The endpoints, which correspond to plasmid origin and terC, were mapped with single-nucleotide precision [2].
  • In a comparative study of the sequences of the 3-kb regions of DNA spanning the replication terminus, terC, of Bacillus subtilis strains 168 and W23, it was found that the latter contained an insertion of a large open reading frame (ORF405) whose translated protein product is a member of the cytochrome P-450 family [5].
  • The DNA inserts of these cosmids were confined to three regions of a 350-kilobase segment of the chromosome extending from the left end of the SP beta prophage to approximately 75 kilobases on the right of terC [3].
  • From a library of Bacillus subtilis DNA cloned with the Escherichia coli cosmid vector pHC79, 85 recombinant cosmids containing DNA from near the replication terminus, terC, were identified [3].
 

Biological context of terC

  • We examined the origin usage during iSDR and found that the initiation of iSDR occurs primarily in the oriC and terC regions of the chromosome in a manner completely independent of transcription, translation and DnaA protein [6].
  • Analysis of the DNA synthesized at high temperature by hybridization with probe DNAs for detection of DNA replicated in the origin (oriC) and terminal (terC) regions has revealed that this mutant is unable to initiate a new round of DNA replication at high temperature after termination of the round in progress [7].
 

Other interactions of terC

  • The terminus of replication (terC) of the chromosome of Escherichia coli is located between the rac (min 30.0) and manA (min 35.7) loci, presumably close to the trg (min 31.4) locus [8].
  • Hybrid plasmids carrying trg, the genetic locus in closest proximity to terC, coded for several polypeptides in addition to the Trg protein [9].
 

Analytical, diagnostic and therapeutic context of terC

References

  1. Requirement of IS911 replication before integration defines a new bacterial transposition pathway. Duval-Valentin, G., Marty-Cointin, B., Chandler, M. EMBO J. (2004) [Pubmed]
  2. Unidirectional theta replication of the structurally stable Enterococcus faecalis plasmid pAM beta 1. Bruand, C., Ehrlich, S.D., Jannière, L. EMBO J. (1991) [Pubmed]
  3. Nonrandom cosmid cloning and prophage SP beta homology near the replication terminus of the Bacillus subtilis chromosome. Rowe, D.B., Iismaa, T.P., Wake, R.G. J. Bacteriol. (1986) [Pubmed]
  4. Dysfunctional MreB inhibits chromosome segregation in Escherichia coli. Kruse, T., Møller-Jensen, J., Løbner-Olesen, A., Gerdes, K. EMBO J. (2003) [Pubmed]
  5. Variations and coding features of the sequence spanning the replication terminus of Bacillus subtilis 168 and W23 chromosomes. Ahn, K.S., Wake, R.G. Gene (1991) [Pubmed]
  6. DNA damage-inducible origins of DNA replication in Escherichia coli. Magee, T.R., Asai, T., Malka, D., Kogoma, T. EMBO J. (1992) [Pubmed]
  7. The dnaK gene of Escherichia coli functions in initiation of chromosome replication. Sakakibara, Y. J. Bacteriol. (1988) [Pubmed]
  8. Deletion of 60 kilobase pairs of DNA from the terC region of the chromosome of Escherichia coli. Henson, J.M., Kopp, B., Kuempel, P.L. Mol. Gen. Genet. (1984) [Pubmed]
  9. A gene coding for a periplasmic protein is located near the locus for termination of chromosome replication in Escherichia coli. Harayama, S., Hazelbauer, G.L. J. Bacteriol. (1982) [Pubmed]
  10. Insertion and deletion mutations in the repA4 region of the IncFII plasmid NR1 cause unstable inheritance. Jiang, T., Min, Y.N., Liu, W., Womble, D.D., Rownd, R.H. J. Bacteriol. (1993) [Pubmed]
  11. Genomic variability of O islands encoding tellurite resistance in enterohemorrhagic Escherichia coli O157:H7 isolates. Taylor, D.E., Rooker, M., Keelan, M., Ng, L.K., Martin, I., Perna, N.T., Burland, N.T., Blattner, F.R. J. Bacteriol. (2002) [Pubmed]
 
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