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Gene Review

Hist2h3c2  -  histone cluster 2, H3c2

Mus musculus

Synonyms: H3-614, H3.2-614, Hist2h3c2-ps, Hist2h3ca1, M32461
 
 
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High impact information on Hist2h3c2

  • If all or part of the normal 3'-processing signal, consisting of the stem-loop and the U7 small nuclear ribonucleoprotein binding site, is deleted, transcription then continues past the putative termination site and RNAs which end at the 3' end of the downstream H3-614 gene accumulate [1].
  • The histone gene cluster on mouse chromosome 3 has been isolated as a series of overlapping P1 clones, covering 110-120 kb, by probing with the histone H3-614 gene that had been mapped previously to mouse chromosome 3 [2].

References

  1. An intact histone 3'-processing site is required for transcription termination in a mouse histone H2a gene. Chodchoy, N., Pandey, N.B., Marzluff, W.F. Mol. Cell. Biol. (1991) [Pubmed]
  2. Characterization of the 55-kb mouse histone gene cluster on chromosome 3. Wang, Z.F., Tisovec, R., Debry, R.W., Frey, M.R., Matera, A.G., Marzluff, W.F. Genome Res. (1996) [Pubmed]
 
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