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Gene Review

CDC5L  -  cell division cycle 5-like

Homo sapiens

Synonyms: CDC5, CDC5-LIKE, CEF1, Cdc5-like protein, Cell division cycle 5-like protein, ...
 
 
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Disease relevance of CDC5L

 

High impact information on CDC5L

  • This work reports a first purification and characterization of a functional, human non-snRNA spliceosome subunit containing CDC5L and at least five additional protein factors [3].
  • These results strongly suggest that Cdc5-like protein exists in all eukaryotes and may function in cell cycle regulation [4].
  • The nuclear protein NIPP1 (nuclear inhibitor of protein Ser/Thr phosphatase-1) interacts with the splicing factors SAP155 and CDC5L and is involved in a late step of spliceosome assembly [5].
  • Thus, a direct interaction between the CDC5L protein and PLRG1 in the CDC5L complex is essential for pre-mRNA splicing progression [6].
  • NIPP1-mediated interaction of protein phosphatase-1 with CDC5L, a regulator of pre-mRNA splicing and mitotic entry [7].
 

Biological context of CDC5L

  • CDC5L encodes a protein that is related to the product of the Schizosaccharomyces pombe Cdc5 gene, which exerts its effects at the G2/M transition during cell cycle progression [1].
  • In this report, we show that the CDC5L gene on chromosome 6p is rearranged in the cells of the fetus [1].
  • We have established the genomic organization of the CDC5L gene and found that it consists of at least 16 exons spanning approximately 50 kb of chromosome segment 6p21 [1].
  • This movement correlated temporally with an increase in PCDC5RP phosphorylation [8].
  • PCDC5RP contains two tandem repeats of a helix-turn-helix DNA binding motif, four consensus nuclear localization signals, and a hydrophilic, proline-rich central region similar to the transcriptional activating domain in Myb family members [8].
 

Anatomical context of CDC5L

 

Associations of CDC5L with chemical compounds

  • CDC5L was also predicted to contain a hydrophilic, proline-rich region in its central part, which might function as a transcriptional activating domain [1].
 

Physical interactions of CDC5L

  • hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing [9].
 

Other interactions of CDC5L

  • A direct interaction between the carboxyl-terminal region of CDC5L and the WD40 domain of PLRG1 is essential for pre-mRNA splicing [6].
  • We also found that a truncated hLodestar/HuF2 polypeptide that overlaps with the CDC5L-binding region can inhibit pre-mRNA splicing by disrupting spliceosome assembly [9].
 

Analytical, diagnostic and therapeutic context of CDC5L

References

  1. Rearrangement of the human CDC5L gene by a t(6;19)(p21;q13.1) in a patient with multicystic renal dysplasia. Groenen, P.M., Vanderlinden, G., Devriendt, K., Fryns, J.P., Van de Ven, W.J. Genomics (1998) [Pubmed]
  2. Adenoviral delivery of human CDC5 promotes G2/M progression and cell division in neonatal ventricular cardiomyocytes. Williams, S.D., Zhu, H., Zhang, L., Bernstein, H.S. Gene Ther. (2006) [Pubmed]
  3. Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry. Ajuh, P., Kuster, B., Panov, K., Zomerdijk, J.C., Mann, M., Lamond, A.I. EMBO J. (2000) [Pubmed]
  4. A cdc5+ homolog of a higher plant, Arabidopsis thaliana. Hirayama, T., Shinozaki, K. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  5. The protein phosphatase-1 (PP1) regulator, nuclear inhibitor of PP1 (NIPP1), interacts with the polycomb group protein, embryonic ectoderm development (EED), and functions as a transcriptional repressor. Jin, Q., van Eynde, A., Beullens, M., Roy, N., Thiel, G., Stalmans, W., Bollen, M. J. Biol. Chem. (2003) [Pubmed]
  6. A direct interaction between the carboxyl-terminal region of CDC5L and the WD40 domain of PLRG1 is essential for pre-mRNA splicing. Ajuh, P., Sleeman, J., Chusainow, J., Lamond, A.I. J. Biol. Chem. (2001) [Pubmed]
  7. NIPP1-mediated interaction of protein phosphatase-1 with CDC5L, a regulator of pre-mRNA splicing and mitotic entry. Boudrez, A., Beullens, M., Groenen, P., Van Eynde, A., Vulsteke, V., Jagiello, I., Murray, M., Krainer, A.R., Stalmans, W., Bollen, M. J. Biol. Chem. (2000) [Pubmed]
  8. Pombe Cdc5-related protein. A putative human transcription factor implicated in mitogen-activated signaling. Bernstein, H.S., Coughlin, S.R. J. Biol. Chem. (1997) [Pubmed]
  9. hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing. Leonard, D., Ajuh, P., Lamond, A.I., Legerski, R.J. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
 
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