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Gene Review

MRC2  -  mannose receptor, C type 2

Homo sapiens

Synonyms: C-type lectin domain family 13 member E, C-type mannose receptor 2, CD280, CLEC13E, ENDO180, ...
 
 
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Disease relevance of MRC2

  • Together with the observed restricted expression of Endo180 in both embryonic and adult tissue, we propose that Endo180 plays a physiological role in mediating collagen matrix remodelling during tissue development and homeostasis and that the observed receptor upregulation in pathological conditions may contribute to disease progression [1].
  • Whereas the normal breast tissue was uPARAP-negative, all benign lesions and ductal carcinoma in situ lesions showed immunoreactivity in fibroblast-like cells and myoepithelial cells associated with the lesion [2].
  • In order to ascertain whether there is a relationship between Endo180 binding and procollagenase 3 activation, we have compared procollagenase 3 activation by an HT1080 fibrosarcoma cell line overexpressing MT1 MMP, without and with overexpression of Endo180 [3].
  • Increased Expression of the Collagen Internalization Receptor uPARAP/Endo180 in the Stroma of Head and Neck Cancer [4].
  • In addition, our data indicates that Endo180 does not appear to play a role in the development or progression of murine osteoarthritis [5].
 

High impact information on MRC2

  • Moreover, we provide evidence for a cellular mechanism in which Endo180-containing endosomes are spatially localized to facilitate their contractile signals directly at sites of adhesion turnover [6].
  • From these studies, we conclude that Endo180 is a crucial link between uPA-uPAR and setting of the internal cellular compass [7].
  • Structural model for the mannose receptor family uncovered by electron microscopy of Endo180 and the mannose receptor [8].
  • The collagen receptor, uPAR-AP/Endo-180, is also increased in LRP-1-deficient MEFs [9].
  • In addition, cross-linking studies have identified Endo180 as a urokinase plasminogen activator receptor-associated protein and this interaction can be blocked by collagen V [1].
 

Biological context of MRC2

 

Anatomical context of MRC2

 

Associations of MRC2 with chemical compounds

  • Competition assays indicate that the monosaccharide binding specificity of Endo180 CTLD2 is similar to that of mannose receptor CTLD4 [11].
  • Identification and characterization of the endocytic transmembrane glycoprotein Endo180 as a novel collagen receptor [1].
  • Unexpectedly, Endo180 was found to be distinct within the family in that the tyrosine-based motif is not required for efficient delivery to and recycling from early endosomes [12].
  • However, additional experiments indicate that, unlike the cysteine-rich domain of the mannose receptor, the cysteine-rich domain of Endo180 does not bind sulfated sugars [11].
 

Physical interactions of MRC2

 

Other interactions of MRC2

  • Four to five years of follow-up revealed that the muscle power of the interosseous muscles and adductor pollicis was MRC2 in one case, MRC1 in three cases, and MRC0 in one case [13].
  • The urokinase receptor associated protein (uPARAP/endo180): a novel internalization receptor connected to the plasminogen activation system [14].
  • Investigation of the role of Endo180/urokinase-type plasminogen activator receptor-associated protein as a collagenase 3 (matrix metalloproteinase 13) receptor [3].
  • FNII domains are known to be important for collagen binding and this has been studied in the context of two members of the MR family, Endo180 and the phospholipase A(2) receptor [15].
  • This review discusses the structure and function of these four proteins-the mannose receptor (MR), the M-type receptor for secretory phospholipases A(2) (PLA(2)R), DEC-205/gp200-MR6 and Endo180/uPARAP [16].
 

Analytical, diagnostic and therapeutic context of MRC2

References

  1. Identification and characterization of the endocytic transmembrane glycoprotein Endo180 as a novel collagen receptor. Wienke, D., MacFadyen, J.R., Isacke, C.M. Mol. Biol. Cell (2003) [Pubmed]
  2. Urokinase receptor-associated protein (uPARAP) is expressed in connection with malignant as well as benign lesions of the human breast and occurs in specific populations of stromal cells. Schnack Nielsen, B., Rank, F., Engelholm, L.H., Holm, A., Danø, K., Behrendt, N. Int. J. Cancer (2002) [Pubmed]
  3. Investigation of the role of Endo180/urokinase-type plasminogen activator receptor-associated protein as a collagenase 3 (matrix metalloproteinase 13) receptor. Bailey, L., Wienke, D., Howard, M., Knäuper, V., Isacke, C.M., Murphy, G. Biochem. J. (2002) [Pubmed]
  4. Increased Expression of the Collagen Internalization Receptor uPARAP/Endo180 in the Stroma of Head and Neck Cancer. Sulek, J., Wagenaar-Miller, R.A., Shireman, J., Molinolo, A., Madsen, D.H., Engelholm, L.H., Behrendt, N., Bugge, T.H. J. Histochem. Cytochem. (2007) [Pubmed]
  5. Distribution of Endo180 receptor and ligand in developing articular cartilage. Howard, M.J., Chambers, M.G., Mason, R.M., Isacke, C.M. Osteoarthr. Cartil. (2004) [Pubmed]
  6. Endosomes generate localized Rho-ROCK-MLC2-based contractile signals via Endo180 to promote adhesion disassembly. Sturge, J., Wienke, D., Isacke, C.M. J. Cell Biol. (2006) [Pubmed]
  7. GPI-anchored uPAR requires Endo180 for rapid directional sensing during chemotaxis. Sturge, J., Wienke, D., East, L., Jones, G.E., Isacke, C.M. J. Cell Biol. (2003) [Pubmed]
  8. Structural model for the mannose receptor family uncovered by electron microscopy of Endo180 and the mannose receptor. Boskovic, J., Arnold, J.N., Stilion, R., Gordon, S., Sim, R.B., Rivera-Calzada, A., Wienke, D., Isacke, C.M., Martinez-Pomares, L., Llorca, O. J. Biol. Chem. (2006) [Pubmed]
  9. Regulation of the composition of the extracellular matrix by low density lipoprotein receptor-related protein-1: activities based on regulation of mRNA expression. Gaultier, A., Salicioni, A.M., Arandjelovic, S., Gonias, S.L. J. Biol. Chem. (2006) [Pubmed]
  10. Expression of Endo180 is spatially and temporally regulated during wound healing. Honardoust, H.A., Jiang, G., Koivisto, L., Wienke, D., Isacke, C.M., Larjava, H., H??kkinen, L. Histopathology (2006) [Pubmed]
  11. Characterization of sugar binding by the mannose receptor family member, Endo180. East, L., Rushton, S., Taylor, M.E., Isacke, C.M. J. Biol. Chem. (2002) [Pubmed]
  12. The C-type lectin receptor Endo180 displays internalization and recycling properties distinct from other members of the mannose receptor family. Howard, M.J., Isacke, C.M. J. Biol. Chem. (2002) [Pubmed]
  13. Femoral nerve transfer for treatment of brachial plexus root avulsion. Gu, Y.D., Cheng, X.M., Chen, D.S., Zhang, G.M., Xu, J.G., Chen, L., Zhang, L.Y., Cai, P.Q. Plast. Reconstr. Surg. (1998) [Pubmed]
  14. The urokinase receptor associated protein (uPARAP/endo180): a novel internalization receptor connected to the plasminogen activation system. Engelholm, L.H., Nielsen, B.S., Danø, K., Behrendt, N. Trends Cardiovasc. Med. (2001) [Pubmed]
  15. Carbohydrate-independent recognition of collagens by the macrophage mannose receptor. Martinez-Pomares, L., Wienke, D., Stillion, R., McKenzie, E.J., Arnold, J.N., Harris, J., McGreal, E., Sim, R.B., Isacke, C.M., Gordon, S. Eur. J. Immunol. (2006) [Pubmed]
  16. The mannose receptor family. East, L., Isacke, C.M. Biochim. Biophys. Acta (2002) [Pubmed]
 
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