Gene Review:
CDC25A - cell division cycle 25A
Homo sapiens
Synonyms:
Dual specificity phosphatase Cdc25A, M-phase inducer phosphatase 1
- Overexpression of CDC25A phosphatase is associated with hypergrowth activity and poor prognosis of human hepatocellular carcinomas. Xu, X., Yamamoto, H., Sakon, M., Yasui, M., Ngan, C.Y., Fukunaga, H., Morita, T., Ogawa, M., Nagano, H., Nakamori, S., Sekimoto, M., Matsuura, N., Monden, M. Clin. Cancer Res. (2003)
- G1 cell cycle progression and the expression of G1 cyclins are regulated by PI3K/AKT/mTOR/p70S6K1 signaling in human ovarian cancer cells. Gao, N., Flynn, D.C., Zhang, Z., Zhong, X.S., Walker, V., Liu, K.J., Shi, X., Jiang, B.H. Am. J. Physiol., Cell Physiol. (2004)
- Expression of cell cycle regulators in human cutaneous malignant melanoma. Tang, L., Li, G., Tron, V.A., Trotter, M.J., Ho, V.C. Melanoma Res. (1999)
- Cell cycle-related phosphatases CDC25A and B expression correlates with survival in ovarian cancer patients. Broggini, M., Buraggi, G., Brenna, A., Riva, L., Codegoni, A.M., Torri, V., Lissoni, A.A., Mangioni, C., D'Incalci, M. Anticancer Res. (2000)
- Expression of cyclin-dependent kinases and CDC25a phosphatase is related with recurrences and survival in women with peri- and post-menopausal breast cancer. Bonin, S., Brunetti, D., Benedetti, E., Gorji, N., Stanta, G. Virchows Arch. (2006)
- Dual mode of degradation of Cdc25 A phosphatase. Donzelli, M., Squatrito, M., Ganoth, D., Hershko, A., Pagano, M., Draetta, G.F. EMBO J. (2002)
- Transforming growth factor beta targeted inactivation of cyclin E:cyclin-dependent kinase 2 (Cdk2) complexes by inhibition of Cdk2 activating kinase activity. Nagahara, H., Ezhevsky, S.A., Vocero-Akbani, A.M., Kaldis, P., Solomon, M.J., Dowdy, S.F. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Multifaceted regulation of cell cycle progression by estrogen: regulation of Cdk inhibitors and Cdc25A independent of cyclin D1-Cdk4 function. Foster, J.S., Henley, D.C., Bukovsky, A., Seth, P., Wimalasena, J. Mol. Cell. Biol. (2001)
- DNA damage during the spindle-assembly checkpoint degrades CDC25A, inhibits cyclin-CDC2 complexes, and reverses cells to interphase. Chow, J.P., Siu, W.Y., Fung, T.K., Chan, W.M., Lau, A., Arooz, T., Ng, C.P., Yamashita, K., Poon, R.Y. Mol. Biol. Cell (2003)
- Regulation of the mammalian cell cycle: a model of the G1-to-S transition. Qu, Z., Weiss, J.N., MacLellan, W.R. Am. J. Physiol., Cell Physiol. (2003)
- Overexpression of cyclin-dependent kinase-activating CDC25B phosphatase in human gastric carcinomas. Kudo, Y., Yasui, W., Ue, T., Yamamoto, S., Yokozaki, H., Nikai, H., Tahara, E. Jpn. J. Cancer Res. (1997)
- The cell cycle-regulatory CDC25A phosphatase inhibits apoptosis signal-regulating kinase 1. Zou, X., Tsutsui, T., Ray, D., Blomquist, J.F., Ichijo, H., Ucker, D.S., Kiyokawa, H. Mol. Cell. Biol. (2001)
- Overexpression of CDC25A and CDC25B in head and neck cancers. Gasparotto, D., Maestro, R., Piccinin, S., Vukosavljevic, T., Barzan, L., Sulfaro, S., Boiocchi, M. Cancer Res. (1997)
- Association of meiotic arrest with lack of BOULE protein expression in infertile men. Luetjens, C.M., Xu, E.Y., Rejo Pera, R.A., Kamischke, A., Nieschlag, E., Gromoll, J. J. Clin. Endocrinol. Metab. (2004)
- Aloesin up-regulates cyclin E/CDK2 kinase activity via inducing the protein levels of cyclin E, CDK2, and CDC25A in SK-HEP-1 cells. Lee, K.Y., Park, J.H., Chung, M.H., Park, Y.I., Kim, K.W., Lee, Y.J., Lee, S.K. Biochem. Mol. Biol. Int. (1997)
- Lack of PTEN sequesters CHK1 and initiates genetic instability. Puc, J., Keniry, M., Li, H.S., Pandita, T.K., Choudhury, A.D., Memeo, L., Mansukhani, M., Murty, V.V., Gaciong, Z., Meek, S.E., Piwnica-Worms, H., Hibshoosh, H., Parsons, R. Cancer Cell (2005)
- Molecular modes of action of artesunate in tumor cell lines. Efferth, T., Sauerbrey, A., Olbrich, A., Gebhart, E., Rauch, P., Weber, H.O., Hengstler, J.G., Halatsch, M.E., Volm, M., Tew, K.D., Ross, D.D., Funk, J.O. Mol. Pharmacol. (2003)
- Resveratrol-induced G2 arrest through the inhibition of CDK7 and p34CDC2 kinases in colon carcinoma HT29 cells. Liang, Y.C., Tsai, S.H., Chen, L., Lin-Shiau, S.Y., Lin, J.K. Biochem. Pharmacol. (2003)
- Coscinosulfate, a CDC25 phosphatase inhibitor from the sponge Coscinoderma mathewsi. Loukaci, A., Le Saout, I., Samadi, M., Leclerc, S., Damiens, E., Meijer, L., Debitus, C., Guyot, M. Bioorg. Med. Chem. (2001)
- A fission yeast strain expressing human CDC25A phosphatase: a tool for selectivity studies of pharmacological inhibitors of CDC25. Mondesert, O., Lemaire, M., Brezak, M.C., Galera-Contour, M.O., Prevost, G., Ducommun, B., Bugler, B. Curr. Genet. (2004)
- The Chk1/Cdc25A pathway as activators of the cell cycle in neuronal death induced by camptothecin. Zhang, Y., Qu, D., Morris, E.J., O'Hare, M.J., Callaghan, S.M., Slack, R.S., Geller, H.M., Park, D.S. J. Neurosci. (2006)
- Chromosome mapping of human CDC25A and CDC25B phosphatases. Demetrick, D.J., Beach, D.H. Genomics (1993)
- Alternative splicing in the regulatory region of the human phosphatases CDC25A and CDC25C. Wegener, S., Hampe, W., Herrmann, D., Schaller, H.C. Eur. J. Cell Biol. (2000)
- Low frequency of CHEK2 1100delC allele in Australian multiple-case breast cancer families: functional analysis in heterozygous individuals. Jekimovs, C.R., Chen, X., Arnold, J., Gatei, M., Richard, D.J., Spurdle, A.B., Khanna, K.K., Chenevix-Trench, G. Br. J. Cancer (2005)
- Anomalies of the TGF-beta postreceptor signaling pathway in ovarian cancer cell lines. Hu, W., Wu, W., Nash, M.A., Freedman, R.S., Kavanagh, J.J., Verschraegen, C.F. Anticancer Res. (2000)