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GFPT2  -  glutamine-fructose-6-phosphate transaminase 2

Homo sapiens

Synonyms: D-fructose-6-phosphate amidotransferase 2, GFAT 2, GFAT2, Glutamine:fructose-6-phosphate amidotransferase 2, Hexosephosphate aminotransferase 2
 
 
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Disease relevance of GFPT2

 

High impact information on GFPT2

  • GFAT1 is ubiquitous, whereas GFAT2 is expressed mainly in the central nervous system [2].
  • Glutamine:fructose-6-phosphate amidotransferase (GFPT), the rate limiting enzyme in hexosamine biosynthesis, is encoded by the unlinked but highly homologous genes GFPT1 and GFPT2 [3].
  • GFPT2 mRNA levels in transformed lymphocytes from study subjects were significantly increased among African-American subjects compared with Caucasian individuals, regardless of diagnosis [3].
  • Common variants in glutamine:fructose-6-phosphate amidotransferase 2 (GFPT2) gene are associated with type 2 diabetes, diabetic nephropathy, and increased GFPT2 mRNA levels [3].
  • The protective effect of GFPT2 against H(2)O(2) toxicity in neuronal HT-22 cells may be similar to its protection against methylmercury in yeast [1].
 

Biological context of GFPT2

References

  1. High-throughput functional genomics identifies genes that ameliorate toxicity due to oxidative stress in neuronal HT-22 cells: GFPT2 protects cells against peroxide. Zitzler, J., Link, D., Schäfer, R., Liebetrau, W., Kazinski, M., Bonin-Debs, A., Behl, C., Buckel, P., Brinkmann, U. Mol. Cell Proteomics (2004) [Pubmed]
  2. A novel variant of glutamine: fructose-6-phosphate amidotransferase-1 (GFAT1) mRNA is selectively expressed in striated muscle. DeHaven, J.E., Robinson, K.A., Nelson, B.A., Buse, M.G. Diabetes (2001) [Pubmed]
  3. Common variants in glutamine:fructose-6-phosphate amidotransferase 2 (GFPT2) gene are associated with type 2 diabetes, diabetic nephropathy, and increased GFPT2 mRNA levels. Zhang, H., Jia, Y., Cooper, J.J., Hale, T., Zhang, Z., Elbein, S.C. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  4. Site-specific Tn7 transposition into the human genome. Kuduvalli, P.N., Mitra, R., Craig, N.L. Nucleic Acids Res. (2005) [Pubmed]
 
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