Disease relevance of Adenocarcinoma, Scirrhous

• Moreover, the incidence of enhanced expression of PDGF receptor mRNA was higher in scirrhous carcinoma than in well differentiated adenocarcinoma [1].
• An immunohistochemical study revealed no hEGF-immunoreactivity in early gastric carcinomas, while hEGF-positive tumor cells were detected in 24 (21.2%) of the 113 advanced carcinomas and in 15 (33.3%) of the 45 scirrhous carcinomas [2].
• BACKGROUND: The aim of the present study was to examine the immunohistochemical distribution of the 47-kDa heat shock protein (HSP47) to enhance the understanding of the mechanisms involved in stromal fibrosis, which accompanies cancer infiltration in scirrhous carcinoma of the stomach [3].
• Mucin antigens expression and Ki-67 labeling in breast cancer: the peculiarity in scirrhous carcinoma [4].

High impact information on Adenocarcinoma, Scirrhous

• Microscopically, the tumors were infiltrative, scirrhous adenocarcinomas that produced varying amounts of mucin [5].
• Our results suggest that TGF-beta 1 induces cell death in human gastric scirrhous carcinoma cells in vitro which is mediated by activation of a signal transduction pathway for apoptosis [6].
• Of 10 scirrhous carcinomas, 6 produced lactalbumin, but none responded to prolactin treatment [7].
• Scirrhous carcinoma tissues contained a relatively large amount of hyaluronic acid and chondroitin sulfate [8].
• The correlation of tumor types of sparse cellularity, as well as prominent stroma content ('scirrhous carcinoma') with increased frequency of the constellation DCCA-neg/ICA-pos was of borderline significance for PgR (p = 0.06), but not for ER [9].

Chemical compound and disease context of Adenocarcinoma, Scirrhous

• Gastric carcinoma in dogs produced by the combined use of N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG) and gastrin--with special reference to development of scirrhous carcinoma [10].

Gene context of Adenocarcinoma, Scirrhous

• MMP-1 staining in carcinoma cells was significantly higher in scirrhous carcinoma than in other types of carcinoma [11].
• These results suggest that immunohistochemical expression of TGF-beta1 is one of the useful predictors for estimating the patients' survival in scirrhous carcinoma of the stomach particularly of the T3 and T4 stages [12].
• A frequent development of scirrhous carcinoma was demonstrated in the group treated with gastrin [13].
• The losses of E-cadherin expression in gastric and breast scirrhous adenocarcinomas were 18.1% and 0%, respectively, and those of alpha catenin expression were 54.6% and 75%, respectively [14].
• Immunohistochemical distribution of heat shock protein 47 (HSP47) in scirrhous carcinoma of the stomach [3].

Analytical, diagnostic and therapeutic context of Adenocarcinoma, Scirrhous

• To investigate the mechanisms of disruption of cell-cell contact in scirrhous carcinoma cells, the expression of both E-cadherin and alpha catenin, which is an intracellular cadherin-binding molecule, were determined in scirrhous-type adenocarcinomas of the stomach and breast using immunohistochemical and immunoblotting techniques [14].

References