Disease relevance of Clinical Medicine

• Images in clinical medicine. Digoxin-induced bidirectional ventricular tachycardia [1].
• Images in clinical medicine. Tamoxifen-induced endometrial polyp [2].
• Images in clinical medicine. Fish-tank granuloma [3].
• Images in clinical medicine. Brain herniation in toxoplasmosis [4].
• Images in clinical medicine. Sand as a foreign body [5].

Psychiatry related information on Clinical Medicine

• Hence, the question as to whether MCS should be regarded as a clinically defined entity remains controversial, but important progress can be noticed in elucidating and defining the nature of this phenomenon, by a combined effort of several disciplines (toxicology and behavioural toxicology, psychology and psychophysiology, and clinical medicine) [6].

High impact information on Clinical Medicine

• Images in clinical medicine. Renal-cell carcinoma extending into the vena cava and right side of the heart [7].
• Images in clinical medicine. Pigmentation related to amiodarone [8].
• Images in clinical medicine. Nail injury to the skull [9].
• Images in clinical medicine. Complication of Cantor-tube insertion [10].
• Images in clinical medicine. Scurvy [11].

Chemical compound and disease context of Clinical Medicine

• Indirect consequences of immune complex disease may still be appraised and evaluated with some confidence in clinical medicine: measurements of C3 and C4, cryoglobulins, serum viscosity, and turbidity of serum samples [12].
• Disorders of potassium (K+) homeostasis are frequently encountered in clinical medicine and may have serious sequelae, particularly cardiac arrhythmias [13].
• The administration of 50% dextrose should be reserved for those patients in whom hypoglycemia is demonstrated; this practice will uphold Hippocrates' most basic principle of clinical medicine, "The physician must ... do no harm."[14]
• New diuretics introduced into clinical medicine during the past decade include potent new loop diuretics such as bumetanide and piretanide, the uricosuric indanyloxyacetic acid derivative indacrinone, and a new generation of sulfamoyl diuretics such as indapamide and xipamide, which are recommended primarily for the treatment of hypertension [15].
• Critical illness initiates some of the most profound alterations in interorgan glutamine metabolism observed in the laboratory as well as in clinical medicine [16].

Biological context of Clinical Medicine

• Our understanding of the immunobiology of PBC has dramatically changed with the application of molecular biology to clinical medicine [17].
• As a result of these observations, the TPMT genetic polymorphism represents a model system for the way in which basic pharmacogenetic information is developed and applied to clinical medicine [18].
• It includes concepts of human neurobiology and neuropharmacology and their application to clinical medicine, as well as the presentation of the clinical evidence on the therapeutic efficacy and safety of amisulpride in schizophrenia, highlighting dosage issues [19].
• The discovery nearly two decades ago that levels of TPMT activity in human tissues are controlled by a common genetic polymorphism led to one of the best examples of the potential importance of pharmacogenetics for clinical medicine [18].
• The essentiality of coenzyme Q for bioenergetics and clinical medicine [20].

Anatomical context of Clinical Medicine

• NMDA receptors, glial cells, and clinical medicine [21].
• These actions underpin its rapid uptake into clinical medicine as a drug that increases the production of neutrophils in patients with chemotherapy-induced neutropenia.Ongoing research has uncovered initially unsuspected polyfunctionality for G-CSF [22].
• Localized peripheral nerve compression is common in clinical medicine; carpal tunnel syndrome is the most common example [23].
• The presence of amyloid within the islet of the pancreas may be one of the best kept secrets in clinical medicine and translation of this century old finding may help to better understand the progressive nature of type 2 diabetes mellitus [24].

Associations of Clinical Medicine with chemical compounds

• Images in clinical medicine. Cholesterol crystals [25].
• Images in clinical medicine. Heparin-induced skin necrosis [26].
• Images in clinical medicine. Captopril-augmented renal scan [27].
• Images in clinical medicine. Indinavir crystalluria [28].
• Images in clinical medicine. Cystine crystals in Fanconi's syndrome [29].

Gene context of Clinical Medicine

• Such information is essential in view of the recent introduction of endothelin-receptor blockers in clinical medicine [30].
• This understanding is also important so that physicians can critically evaluate the basis for, and the emerging data on, COX-2-specific inhibitors and their potential role in clinical medicine [31].
• The aquaporin family of water channel proteins in clinical medicine [32].
• Two inhibitors of PDE3A are used in clinical medicine: milrinone and cilostazol [33].
• In contrast, agents that reduce the production and/or activity of IL-1 are likely to have an impact on clinical medicine [34].

Analytical, diagnostic and therapeutic context of Clinical Medicine

• As aspects of basic science come to play an increasingly prominent role in clinical medicine, heme oxygenase-1 is one of several molecules emerging as a central player in diseases of the lung and intensive care unit [35].
• However, as in other sectors of clinical medicine, the actual implementation of general gene therapy strategies in clinical practice has been faced with a range of serious difficulties (cf. Smith, Lancet 1999: 354 (suppl 1): 1-4; Lattime & Gerson (eds.), Gene Therapy of Cancer, Academic Press, San Diego, 1999) [36].
• Although numerous clinical trials have demonstrated that cimetidine is efficacious in the treatment of peptic ulcer, fewer studies have examined whether cimetidine reduces the need for surgical therapy when it is prescribed in the noncontrolled environment of clinical medicine [37].
• The applicability of this method to clinical medicine is demonstrated using NO2- -loaded rats as a biological model: following intravenous infusion or intragastric application of NO2-, blood levels of NO2-, NO3- and methemoglobin are measured during 2-64 min [38].
• Thereafter, paraffin and frozen sections were made and stained by the indirect immunoperoxidase method using antisera obtained from commercial sources and used for the immunochemical assay of the blood level of phenobarbital in clinical medicine [39].

References