Disease relevance of Uveitis, Posterior

• A preoperative diagnosis of granulomatous optic neuropathy was based on the presence of mild posterior uveitis, "snowball" opacities in the vitreous ("string of pearl" sign), and a slightly elevated angiotensin-converting enzyme level [1].
• Experimental Autoimmune Uveitis (EAU) induced by retinal antigens, particularly S-antigen, forms a useful model of human chronic intraocular inflammation particularly endogenous posterior uveitis [2].
• SRI 63-441 reduced the anterior uveitis at 24 h and to a lesser extent at 48 h; it also reduced the posterior uveitis at 48 h [3].
• METHODS: Thirty-four patients (43 eyes) with posterior uveitis (31 eyes) and intermediate uveitis (12 eyes) were evaluated by fluorescein angiography, indocyanine green angiography, and optical coherence tomography [4].
• METHODS: Two milligrams of intravitreal triamcinolone acetonide was injected into 34 eyes with persistent macular oedema (17 eyes with macula oedema secondary to posterior uveitis, 13 eyes with diabetic retinopathy, and four with pseudophakic macular oedema) [5].

High impact information on Uveitis, Posterior

• Based upon protein levels in vitreous humor, TNF-alpha/IL-1 beta also induced a posterior uveitis [6].
• Tacrolimus (FK506) in the treatment of posterior uveitis refractory to cyclosporine [7].
• Six of the 18 (33%) BD patients with posterior uveitis showed increased proliferative response to alpha tropomyosin or its derivative peptides, while none of the healthy, disease controls were positive [8].
• Real-time quantitative polymerase chain reaction diagnosis of infectious posterior uveitis [9].
• These results suggest that cellular immunity to cross-reactive HLA-B and S-Ag-derived peptides might play a role in the pathogenesis of posterior uveitis in BD [10].

Chemical compound and disease context of Uveitis, Posterior

• We suggest that a poor visual outcome in some patients with posterior uveitis may be predicted by the presence of macular ischaemia on fluorescein angiography and that immunosuppressive therapy should be prescribed with caution in these patients [11].
• The posterior uveitis was treated with a subtenon injection of triamcinolone [12].
• Interleukin-1 (IL-1) blockers, CK 127 and CK 129, were found to inhibit IL-1-induced posterior uveitis very effectively at 3-10 mg/kg i.p. and were more potent than prednisolone which required at least 20 mg/kg i.p. to achieve the same level of anti-uveitis action [13].
• RESULTS: The patients, who were being treated with rifabutin and fluconazole, developed anterior and posterior uveitis [14].
• OBJECTIVE: To describe a patient with noninfectious anterior and posterior uveitis, refractory to corticosteroids, and immunosuppressive therapy, which responded to systemic metoprolol [15].

Biological context of Uveitis, Posterior

• Forty-six eyes in 26 patients with active, intermediate, and/or posterior uveitis with decreased visual acuity were evaluated with the laser interferometer before treatment with systemic cyclosporine [16].
• Autoimmunity to retinal antigens has been implicated in the pathogenesis of both endogenous posterior uveitis and retinitis pigmentosa [17].
• The different explanatory variables considered included sex, age, preoperative axial length, preoperative average keratometry, preoperative intraocular pressure, glaucoma history, diabetes history, uveitis history (including both anterior and posterior uveitis), and a history of rheumatoid arthritis [18].

Anatomical context of Uveitis, Posterior

• Immunization of Lewis rats with PEP-65 or affinity-purified RPE-TS induces a new type of ocular disease: experimental autoimmune posterior uveitis accompanied by epitheloid cell accumulations (monocytes) adjacent to the RPE (EAPU) [19].

Gene context of Uveitis, Posterior

• We report the successful longterm treatment of a female German patient with erosive arthritis and posterior uveitis with IFN alpha and IFN gamma sequentially and in combination [20].
• Rabbits injected with retina extract or S antigen developed posterior uveitis [21].
• Unlike many other patients with posterior uveitis these did not respond to the retinal S-antigen [22].
• To investigate this question we tested sera from 86 patients with posterior uveitis and 100 healthy controls for the presence of anticardiolipin antibodies [23].
• Experimental posterior uveitis was induced by the inoculation of retinal S-antigen into black hooded Lister rats [24].

References