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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Constriction


Psychiatry related information on Constriction


High impact information on Constriction

  • We show that, in PI3KgammaKD/KD hearts, cAMP levels are normal and that PI3Kgamma-deficient mice but not PI3KgammaKD/KD mice develop dramatic myocardial damage after chronic pressure overload induced by transverse aortic constriction (TAC) [7].
  • Loss of zygotic cnn expression disrupts the development of the second midgut constriction, the gastric caeca, and the nervous system [8].
  • These regulatory interactions are relevant to normal development, because a transgene made with this enhancer driving a dpp transcription unit rescues the second midgut constriction and larval lethality phenotypes of dpps mutations [9].
  • The degree of constriction or dilation during mental stress correlated with the response to the infusions of acetylcholine (P less than 0.0003, r = 0.58) [10].
  • Normal coronary vessels had a biphasic response to intracoronary serotonin: dilation at concentrations up to 10(-5) mol per liter, but constriction at 10(-4) mol per liter [11].

Chemical compound and disease context of Constriction


Biological context of Constriction

  • One type of response consisted of a localised constriction near the noradrenaline source: this effect could be abolished by the alpha-antagonist phentolamine and was not associated with a change in arteriolar membrane potential [17].
  • These arrays efficiently recruit UBF even to sites outside the nucleolus and, during metaphase, form novel silver stainable secondary constrictions, termed pseudo-NORs, morphologically similar to NORs [18].
  • Airway constriction in normal humans produced by inhalation of leukotriene D. Potency, time course, and effect of aspirin therapy [19].
  • Insulin caused no vasoconstriction in either Af- or Ef-Arts, but it reversed norepinephrine-induced constriction in Ef-Arts but not Af-Arts (suggesting a vasodilator action selective to the Ef-Art): at 200 microU/ml, insulin increased Ef-Art luminal diameter by 75.8 +/- 7.0% from the preconstricted level (n = 6; P < 0.008) [20].
  • Chronic infusion of the inhibitor in dogs with thoracic inferior vena caval constriction prevented the restoration of blood pressure and suppressed the rise in plasma aldosterone; sodium retention and volume expansion were less than in control experiments [21].

Anatomical context of Constriction


Associations of Constriction with chemical compounds

  • Most infants responded to indomethacin with ductus constriction [27].
  • Residues of the constriction region, in particular histidine 182, which is conserved among all known water-specific channels, are critical in establishing water specificity [28].
  • Soaking of a crystal with maltotriose revealed binding of the sugar to this hydrophobic track across the constriction, which suggests that maltose and linear oligosaccharides may be translocated across the membrane by guided diffusion along this path [29].
  • Cellular mechanisms mediating rat renal microvascular constriction by angiotensin II [30].
  • Neither asthmatics nor normal subjects had airway constriction or changes in BAL histamine levels in response to nonspecific challenge with cold saline [31].

Gene context of Constriction

  • Heme oxygenase-1 protects against vascular constriction and proliferation [32].
  • Although these Dnm1p-containing complexes are thought to trigger constriction and fission, little is known about their composition and assembly, and molecules required for their membrane recruitment have not been isolated [33].
  • CONCLUSIONS: Selective ETB receptor agonists cause constriction of forearm resistance and hand capacitance vessels in vivo in humans, suggesting that both ETA and ETB receptors mediate vasoconstriction [34].
  • In the wild type, the Bithorax Complex forms a weak point featuring thinner bands separated by clefts or constrictions [35].
  • Taken together, these data indicate that Pbx1 is essential for the function of hematopoietic progenitors with erythropoietic potential and that its loss creates a proliferative constriction at the level of the CMP [36].

Analytical, diagnostic and therapeutic context of Constriction


  1. Supplementary creatine as a treatment for gyrate atrophy of the choroid and retina. Sipilä, I., Rapola, J., Simell, O., Vannas, A. N. Engl. J. Med. (1981) [Pubmed]
  2. Absence of pressure overload induced myocardial hypertrophy after conditional inactivation of Galphaq/Galpha11 in cardiomyocytes. Wettschureck, N., Rütten, H., Zywietz, A., Gehring, D., Wilkie, T.M., Chen, J., Chien, K.R., Offermanns, S. Nat. Med. (2001) [Pubmed]
  3. Inactivation of focal adhesion kinase in cardiomyocytes promotes eccentric cardiac hypertrophy and fibrosis in mice. Peng, X., Kraus, M.S., Wei, H., Shen, T.L., Pariaut, R., Alcaraz, A., Ji, G., Cheng, L., Yang, Q., Kotlikoff, M.I., Chen, J., Chien, K., Gu, H., Guan, J.L. J. Clin. Invest. (2006) [Pubmed]
  4. Neuropeptide-Y. A peptide found in human coronary arteries constricts primarily small coronary arteries to produce myocardial ischemia in dogs. Maturi, M.F., Greene, R., Speir, E., Burrus, C., Dorsey, L.M., Markle, D.R., Maxwell, M., Schmidt, W., Goldstein, S.R., Patterson, R.E. J. Clin. Invest. (1989) [Pubmed]
  5. L-arginine treatment alters the kinetics of nitric oxide and superoxide release and reduces ischemia/reperfusion injury in skeletal muscle. Huk, I., Nanobashvili, J., Neumayer, C., Punz, A., Mueller, M., Afkhampour, K., Mittlboeck, M., Losert, U., Polterauer, P., Roth, E., Patton, S., Malinski, T. Circulation (1997) [Pubmed]
  6. Segmentation induced by intraluminal fatty acid in isolated guinea-pig duodenum and jejunum. Gwynne, R.M., Thomas, E.A., Goh, S.M., Sjövall, H., Bornstein, J.C. J. Physiol. (Lond.) (2004) [Pubmed]
  7. PI3Kgamma modulates the cardiac response to chronic pressure overload by distinct kinase-dependent and -independent effects. Patrucco, E., Notte, A., Barberis, L., Selvetella, G., Maffei, A., Brancaccio, M., Marengo, S., Russo, G., Azzolino, O., Rybalkin, S.D., Silengo, L., Altruda, F., Wetzker, R., Wymann, M.P., Lembo, G., Hirsch, E. Cell (2004) [Pubmed]
  8. The homeotic target gene centrosomin encodes an essential centrosomal component. Li, K., Kaufman, T.C. Cell (1996) [Pubmed]
  9. Direct regulation of decapentaplegic by Ultrabithorax and its role in Drosophila midgut morphogenesis. Capovilla, M., Brandt, M., Botas, J. Cell (1994) [Pubmed]
  10. The effect of atherosclerosis on the vasomotor response of coronary arteries to mental stress. Yeung, A.C., Vekshtein, V.I., Krantz, D.S., Vita, J.A., Ryan, T.J., Ganz, P., Selwyn, A.P. N. Engl. J. Med. (1991) [Pubmed]
  11. Effect of intracoronary serotonin on coronary vessels in patients with stable angina and patients with variant angina. McFadden, E.P., Clarke, J.G., Davies, G.J., Kaski, J.C., Haider, A.W., Maseri, A. N. Engl. J. Med. (1991) [Pubmed]
  12. Hypertrophic stimuli induce transforming growth factor-beta 1 expression in rat ventricular myocytes. Takahashi, N., Calderone, A., Izzo, N.J., Mäki, T.M., Marsh, J.D., Colucci, W.S. J. Clin. Invest. (1994) [Pubmed]
  13. Statins as antioxidant therapy for preventing cardiac myocyte hypertrophy. Takemoto, M., Node, K., Nakagami, H., Liao, Y., Grimm, M., Takemoto, Y., Kitakaze, M., Liao, J.K. J. Clin. Invest. (2001) [Pubmed]
  14. Right atrial pressure-volume relationships in tricuspid regurgitation. Miller, M.J., McKay, R.G., Ferguson, J.J., Sahagian, P., Nakao, S., Come, P.C., Grossman, W. Circulation (1986) [Pubmed]
  15. Aurintricarboxylic acid in a canine model of coronary artery thrombosis. Strony, J., Phillips, M., Brands, D., Moake, J., Adelman, B. Circulation (1990) [Pubmed]
  16. Acute hypertension selectively potentiates constrictor responses of large coronary arteries to serotonin by altering endothelial function in vivo. Lamping, K.G., Dole, W.P. Circ. Res. (1987) [Pubmed]
  17. Evidence for two populations of excitatory receptors for noradrenaline on arteriolar smooth muscle. Hirst, G.D., Neild, T.O. Nature (1980) [Pubmed]
  18. UBF-binding site arrays form pseudo-NORs and sequester the RNA polymerase I transcription machinery. Mais, C., Wright, J.E., Prieto, J.L., Raggett, S.L., McStay, B. Genes Dev. (2005) [Pubmed]
  19. Airway constriction in normal humans produced by inhalation of leukotriene D. Potency, time course, and effect of aspirin therapy. Weiss, J.W., Drazen, J.M., McFadden, E.R., Weller, P., Corey, E.J., Lewis, R.A., Austen, K.F. JAMA (1983) [Pubmed]
  20. Disparate effects of insulin on isolated rabbit afferent and efferent arterioles. Juncos, L.A., Ito, S. J. Clin. Invest. (1993) [Pubmed]
  21. The renin-angiotensin-aldosterone system in congestive failure in conscious dogs. Watkins, L., Burton, J.A., Haber, E., Cant, J.R., Smith, F.W., Barger, A.C. J. Clin. Invest. (1976) [Pubmed]
  22. Activated human eosinophils generate SRS-A leukotrienes following IgG-dependent stimulation. Shaw, R.J., Walsh, G.M., Cromwell, O., Moqbel, R., Spry, C.J., Kay, A.B. Nature (1985) [Pubmed]
  23. Modulation of the response of a photosensitive muscle by beta-adrenergic regulation of cyclic AMP levels. Rubin, L.J., Nolte, J.F. Nature (1984) [Pubmed]
  24. Normalization of depressed heart function in rats by ribose. Zimmer, H.G. Science (1983) [Pubmed]
  25. Inhibitory role of the endothelium in the response of isolated coronary arteries to platelets. Cohen, R.A., Shepherd, J.T., Vanhoutte, P.M. Science (1983) [Pubmed]
  26. Intrinsic defect in T cell production of interleukin (IL)-13 in the absence of both IL-5 and eotaxin precludes the development of eosinophilia and airways hyperreactivity in experimental asthma. Mattes, J., Yang, M., Mahalingam, S., Kuehr, J., Webb, D.C., Simson, L., Hogan, S.P., Koskinen, A., McKenzie, A.N., Dent, L.A., Rothenberg, M.E., Matthaei, K.I., Young, I.G., Foster, P.S. J. Exp. Med. (2002) [Pubmed]
  27. Pharmacokinetics of indomethacin in the neonate. Relation of plasma indomethacin levels to response of the ductus arteriosus. Brash, A.R., Hickey, D.E., Graham, T.P., Stahlman, M.T., Oates, J.A., Cotton, R.B. N. Engl. J. Med. (1981) [Pubmed]
  28. Structural basis of water-specific transport through the AQP1 water channel. Sui, H., Han, B.G., Lee, J.K., Walian, P., Jap, B.K. Nature (2001) [Pubmed]
  29. Structural basis for sugar translocation through maltoporin channels at 3.1 A resolution. Schirmer, T., Keller, T.A., Wang, Y.F., Rosenbusch, J.P. Science (1995) [Pubmed]
  30. Cellular mechanisms mediating rat renal microvascular constriction by angiotensin II. Takenaka, T., Suzuki, H., Fujiwara, K., Kanno, Y., Ohno, Y., Hayashi, K., Nagahama, T., Saruta, T. J. Clin. Invest. (1997) [Pubmed]
  31. Direct evidence of a role for mast cells in the pathogenesis of antigen-induced bronchoconstriction. Casale, T.B., Wood, D., Richerson, H.B., Zehr, B., Zavala, D., Hunninghake, G.W. J. Clin. Invest. (1987) [Pubmed]
  32. Heme oxygenase-1 protects against vascular constriction and proliferation. Duckers, H.J., Boehm, M., True, A.L., Yet, S.F., San, H., Park, J.L., Clinton Webb, R., Lee, M.E., Nabel, G.J., Nabel, E.G. Nat. Med. (2001) [Pubmed]
  33. Dnm1p GTPase-mediated mitochondrial fission is a multi-step process requiring the novel integral membrane component Fis1p. Mozdy, A.D., McCaffery, J.M., Shaw, J.M. J. Cell Biol. (2000) [Pubmed]
  34. Endothelin ETA and ETB receptors cause vasoconstriction of human resistance and capacitance vessels in vivo. Haynes, W.G., Strachan, F.E., Webb, D.J. Circulation (1995) [Pubmed]
  35. The bithorax complex of Drosophila melanogaster: Underreplication and morphology in polytene chromosomes. Moshkin, Y.M., Alekseyenko, A.A., Semeshin, V.F., Spierer, A., Spierer, P., Makarevich, G.F., Belyaeva, E.S., Zhimulev, I.F. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  36. The Hox cofactor and proto-oncogene Pbx1 is required for maintenance of definitive hematopoiesis in the fetal liver. DiMartino, J.F., Selleri, L., Traver, D., Firpo, M.T., Rhee, J., Warnke, R., O'Gorman, S., Weissman, I.L., Cleary, M.L. Blood (2001) [Pubmed]
  37. Endothelium-derived relaxing factor/nitric oxide modulates angiotensin II action in the isolated microperfused rabbit afferent but not efferent arteriole. Ito, S., Arima, S., Ren, Y.L., Juncos, L.A., Carretero, O.A. J. Clin. Invest. (1993) [Pubmed]
  38. EDRF and microvascular constriction after angioplasty. Vallance, P. Lancet (1989) [Pubmed]
  39. Bradykinin-induced vasodilation is impaired at the atherosclerotic site but is preserved at the spastic site of human coronary arteries in vivo. Kuga, T., Egashira, K., Mohri, M., Tsutsui, H., Harasawa, Y., Urabe, Y., Ando, S., Shimokawa, H., Takeshita, A. Circulation (1995) [Pubmed]
  40. Conjugated estrogens acutely abolish abnormal cold-induced coronary vasoconstriction in male cardiac allografts. Reis, S.E., Bhoopalam, V., Zell, K.A., Counihan, P.J., Smith, A.J., Pham, S., Murali, S. Circulation (1998) [Pubmed]
  41. Elevated plasma fibrinopeptide A and thromboxane B2 levels during cardiopulmonary bypass. Davies, G.C., Sobel, M., Salzman, E.W. Circulation (1980) [Pubmed]
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