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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Neurites

 
 
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Disease relevance of Neurites

 

Psychiatry related information on Neurites

 

High impact information on Neurites

  • After dissociation from PARP-1, KIF4 enters into the cytoplasm from the nucleus and moves to the distal part of neurites in a microtubule-dependent manner [11].
  • The expression of the nonphosphorylated form of CRMP-2 or inhibition of GSK-3beta induced the formation of multiple axon-like neurites in hippocampal neurons [12].
  • Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth [13].
  • Here, we report that selection of the future axon among neurites of a cultured hippocampal neuron requires the activity of growth factor receptor tyrosine kinase, phosphatidylinositol 3-kinase (PI 3-kinase), as well as atypical protein kinase C (aPKC) [14].
  • We speculate that through this interaction, TM4SF2 might have a role in the control of neurite outgrowth [15].
 

Chemical compound and disease context of Neurites

 

Biological context of Neurites

  • F-spondin: a gene expressed at high levels in the floor plate encodes a secreted protein that promotes neural cell adhesion and neurite extension [21].
  • Indeed, the co-localization of RAGE and amphoterin at the leading edge of advancing neurites indicated their potential contribution to cellular migration, and in pathologies such as tumour invasion [22].
  • Up-regulation of Notch activity was concomitant with an increase in the number of interneuronal contacts and cessation of neurite growth [23].
  • None of five other proteases were inhibited, and the ability of lactacystin analogs to inhibit cell cycle progression and induce neurite outgrowth correlated with their ability to inhibit the proteasome [24].
  • Additional studies have identified a potential coreceptor for NgR as p75(NTR), and a second-messenger pathway involving RhoA that inhibits neurite elongation [25].
 

Anatomical context of Neurites

 

Associations of Neurites with chemical compounds

  • Cells with neurites are incubated with the microtubule-depolymerizing drug Nocodazole [30].
  • Ligand-induced changes in integrin expression regulate neuronal adhesion and neurite outgrowth [31].
  • We have previously shown that striatal target neurones influence the biochemical maturation of ascending mesencephalic dopamine (DA) cells in culture, as well as the elongation rate of DA neurites [32].
  • Neurite formation induced by cyclic AMP was unaffected by injection of anti-p21 antibody [33].
  • One candidate molecule is laminin, a major glycoprotein of basal laminae which has been shown to induce a wide variety of embryonic neurones to extend neurites in culture [34].
 

Gene context of Neurites

 

Analytical, diagnostic and therapeutic context of Neurites

References

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  17. Laminin promotes neuritic regeneration from cultured peripheral and central neurons. Manthorpe, M., Engvall, E., Ruoslahti, E., Longo, F.M., Davis, G.E., Varon, S. J. Cell Biol. (1983) [Pubmed]
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  20. Binding properties of a cell adhesion molecule from neural tissue. Rutishauser, U., Hoffman, S., Edelman, G.M. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  21. F-spondin: a gene expressed at high levels in the floor plate encodes a secreted protein that promotes neural cell adhesion and neurite extension. Klar, A., Baldassare, M., Jessell, T.M. Cell (1992) [Pubmed]
  22. Blockade of RAGE-amphoterin signalling suppresses tumour growth and metastases. Taguchi, A., Blood, D.C., del Toro, G., Canet, A., Lee, D.C., Qu, W., Tanji, N., Lu, Y., Lalla, E., Fu, C., Hofmann, M.A., Kislinger, T., Ingram, M., Lu, A., Tanaka, H., Hori, O., Ogawa, S., Stern, D.M., Schmidt, A.M. Nature (2000) [Pubmed]
  23. Contact-dependent inhibition of cortical neurite growth mediated by notch signaling. Sestan, N., Artavanis-Tsakonas, S., Rakic, P. Science (1999) [Pubmed]
  24. Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin. Fenteany, G., Standaert, R.F., Lane, W.S., Choi, S., Corey, E.J., Schreiber, S.L. Science (1995) [Pubmed]
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  28. Basal lamina glycoproteins are produced by neuroblastoma cells. Alitalo, K., Kurkinen, M., Vaheri, A., Virtanen, I., Rohde, H., Timpl, R. Nature (1980) [Pubmed]
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