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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Blotting, Southern

 
 
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Disease relevance of Blotting, Southern

 

Psychiatry related information on Blotting, Southern

 

High impact information on Blotting, Southern

  • By Southern blot and 3'-RACE analysis, we demonstrate consistent rearrangements in HMGI-C and/or expression of altered HMGI-C transcripts [7].
  • Interphase in situ results and Southern blot analysis indicate that several further YRRM sequences map within interval 6 [8].
  • We conducted a case-control study, typing 736 HRAS1 alleles from patients with cancer and 652 from controls by Southern blotting of leukocyte DNA [9].
  • Southern blot analyses suggest that pallid is a mutation in the Epb4.2 gene [10].
  • A quantitative end-labeling assay showed that the level of m5C in the DNA of homozygous mutant cells was about one-third that of wild-type cells, and Southern blot analysis after cleavage of the DNA with a methylation-sensitive restriction endonuclease revealed substantial demethylation of endogenous retroviral DNA [11].
 

Chemical compound and disease context of Blotting, Southern

 

Biological context of Blotting, Southern

 

Anatomical context of Blotting, Southern

 

Associations of Blotting, Southern with chemical compounds

  • The continued presence of T-DNA sequences in shoots is directly demonstrated by Southern blotting and is also revealed by the presence of the tumor markers octopine and nopaline [27].
  • The evolutionary lineage of these genes compared to the known functional locus lambda C1-lambda C6 can be surmised from Southern blot and nucleotide homologies [28].
  • Southern blot analysis showed that cells continuously propagated in methionine-supplemented medium (J10met), unlike cells grown in normal medium, progressively segregated the hu-H-ras-1 gene [29].
  • DNA methylation was assessed by cytosine extension assay and by Southern blotting [30].
  • METHODS: Effects of an intragastric dose of ethanol (5 g/kg) on hepatic mitochondrial DNA levels, structure, and synthesis were determined by slot blot hybridization, Southern blot hybridization, and in vivo [3H]thymidine incorporation, respectively [31].
 

Gene context of Blotting, Southern

  • Altered patterns of expression of Mdm2 proteins were determined using an immunohistochemical assay with monoclonal antibody 2A10, and MDM2 gene amplifications were studied by Southern blotting [32].
  • Expression of BCRP messenger RNA (mRNA) and amplification of the BCRP gene were analyzed by northern and Southern blot hybridization, respectively [33].
  • METHODS: We performed Southern blot analysis in 112 patients from MLH1-, MSH2-, and MSH6-negative HNPCC-like families [34].
  • Southern blot analysis of the MUC1 gene was performed on 57 Northern European patients to determine TR allele lengths [35].
  • Southern blot analysis and RNA dot blot analysis demonstrated that the ER variants had lost the amplified EGFR gene [36].
 

Analytical, diagnostic and therapeutic context of Blotting, Southern

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