The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Pharmacokinetics


Psychiatry related information on Pharmacokinetics


High impact information on Pharmacokinetics


Chemical compound and disease context of Pharmacokinetics


Biological context of Pharmacokinetics


Anatomical context of Pharmacokinetics


Associations of Pharmacokinetics with chemical compounds


Gene context of Pharmacokinetics

  • Altered pharmacokinetics of vinblastine in Mdr1a P-glycoprotein-deficient Mice [35].
  • The present studies describe a molecular reformulation of BDNF that incorporates polyethylene glycol (PEG) moieties at surface carboxyl residues, to optimize plasma pharmacokinetics, and links pegylated BDNF to the OX26 mAb, which undergoes receptor-mediated transport through the BBB via the brain capillary endothelial transferrin receptor [36].
  • The safety and pharmacokinetics of VX-710 plus doxorubicin warrant efficacy trials in malignancies expressing P-gp and/or MRP1 [37].
  • PATIENTS AND METHODS: We studied the pharmacokinetics and pharmacodynamics of docetaxel in patients in whom it was indicated and who had not received known CYP3A4 substrates [38].
  • This study investigated the differences between IL-2 and IL-15 in pharmacokinetics, biodistribution, and their tumor-targeting abilities [39].

Analytical, diagnostic and therapeutic context of Pharmacokinetics


  1. Chloroquine treatment of severe malaria in children. Pharmacokinetics, toxicity, and new dosage recommendations. White, N.J., Miller, K.D., Churchill, F.C., Berry, C., Brown, J., Williams, S.B., Greenwood, B.M. N. Engl. J. Med. (1988) [Pubmed]
  2. The bronchodilator effects and pharmacokinetics of caffeine in asthma. Becker, A.B., Simons, K.J., Gillespie, C.A., Simons, F.E. N. Engl. J. Med. (1984) [Pubmed]
  3. A short-term study of the safety, pharmacokinetics, and efficacy of ritonavir, an inhibitor of HIV-1 protease. European-Australian Collaborative Ritonavir Study Group. Danner, S.A., Carr, A., Leonard, J.M., Lehman, L.M., Gudiol, F., Gonzales, J., Raventos, A., Rubio, R., Bouza, E., Pintado, V. N. Engl. J. Med. (1995) [Pubmed]
  4. Pharmacokinetics of indomethacin in the neonate. Relation of plasma indomethacin levels to response of the ductus arteriosus. Brash, A.R., Hickey, D.E., Graham, T.P., Stahlman, M.T., Oates, J.A., Cotton, R.B. N. Engl. J. Med. (1981) [Pubmed]
  5. Intracellular pharmacokinetics of methotrexate polyglutamates in human breast cancer cells. Selective retention and less dissociable binding of 4-NH2-10-CH3-pteroylglutamate4 and 4-NH2-10-CH3-pteroylglutamate5 to dihydrofolate reductase. Jolivet, J., Chabner, B.A. J. Clin. Invest. (1983) [Pubmed]
  6. Naltrexone-induced alterations in human ethanol intoxication. Swift, R.M., Whelihan, W., Kuznetsov, O., Buongiorno, G., Hsuing, H. The American journal of psychiatry. (1994) [Pubmed]
  7. Hypnotics and behavior. Roth, T., Roehrs, T.A., Stepanski, E.J., Rosenthal, L.D. Am. J. Med. (1990) [Pubmed]
  8. Pharmacokinetic study of memantine in healthy and renally impaired subjects. Periclou, A., Ventura, D., Rao, N., Abramowitz, W. Clin. Pharmacol. Ther. (2006) [Pubmed]
  9. A double-blind comparison of lorazepam and oxazepam in psychomotor retardation and mutism. Schmider, J., Standhart, H., Deuschle, M., Drancoli, J., Heuser, I. Biol. Psychiatry (1999) [Pubmed]
  10. Kinetics of cocaine distribution, elimination, and chronotropic effects. Chow, M.J., Ambre, J.J., Ruo, T.I., Atkinson, A.J., Bowsher, D.J., Fischman, M.W. Clin. Pharmacol. Ther. (1985) [Pubmed]
  11. Systemic exposure to mercaptopurine as a prognostic factor in acute lymphocytic leukemia in children. Koren, G., Ferrazini, G., Sulh, H., Langevin, A.M., Kapelushnik, J., Klein, J., Giesbrecht, E., Soldin, S., Greenberg, M. N. Engl. J. Med. (1990) [Pubmed]
  12. Altered sensitivity to and clearance of propranolol in men of Chinese descent as compared with American whites. Zhou, H.H., Koshakji, R.P., Silberstein, D.J., Wilkinson, G.R., Wood, A.J. N. Engl. J. Med. (1989) [Pubmed]
  13. Perinatal pharmacokinetics of zidovudine. Chavanet, P., Diquet, B., Waldner, A., Portier, H. N. Engl. J. Med. (1989) [Pubmed]
  14. Pharmacokinetics of recombinant antihemophilic factor. Longo, G., Messori, A., Morfini, M., di Careggi, O. N. Engl. J. Med. (1989) [Pubmed]
  15. Use of plasma pharmacokinetics to predict and prevent methotrexate toxicity. Stoller, R.G., Hande, K.R., Jacobs, S.A., Rosenberg, S.A., Chabner, B.A. N. Engl. J. Med. (1977) [Pubmed]
  16. Effect of sodium thiosulfate on the pharmacokinetics and toxicity of cisplatin. Goel, R., Cleary, S.M., Horton, C., Kirmani, S., Abramson, I., Kelly, C., Howell, S.B. J. Natl. Cancer Inst. (1989) [Pubmed]
  17. Reversal of advanced digitoxin toxicity and modification of pharmacokinetics by specific antibodies and Fab fragments. Ochs, H.R., Smith, T.W. J. Clin. Invest. (1977) [Pubmed]
  18. Pharmacokinetics of pamidronate in patients with bone metastases. Leyvraz, S., Hess, U., Flesch, G., Bauer, J., Hauffe, S., Ford, J.M., Burckhardt, P. J. Natl. Cancer Inst. (1992) [Pubmed]
  19. Pharmacology and clinical toxicity of 4'-iodo-4'-deoxydoxorubicin: an example of successful application of pharmacokinetics to dose escalation in phase I trials. Gianni, L., Viganò, L., Surbone, A., Ballinari, D., Casali, P., Tarella, C., Collins, J.M., Bonadonna, G. J. Natl. Cancer Inst. (1990) [Pubmed]
  20. Increased plasma protein binding of propranolol and chlorpromazine mediated by disease-induced elevations of plasma alpha1 acid glycoprotein. Piafsky, K.M., Borgá, O., Odar-Cederlöf, I., Johansson, C., Sjöqvist, F. N. Engl. J. Med. (1978) [Pubmed]
  21. Cross-sectional study of a community with exceptional exposure to DDT. Kreiss, K., Zack, M.M., Kimbrough, R.D., Needham, L.L., Smrek, A.L., Jones, B.T. JAMA (1981) [Pubmed]
  22. Antiviral action of ribavirin in chronic hepatitis C. Pawlotsky, J.M., Dahari, H., Neumann, A.U., Hezode, C., Germanidis, G., Lonjon, I., Castera, L., Dhumeaux, D. Gastroenterology (2004) [Pubmed]
  23. Is methylphenidate like cocaine? Studies on their pharmacokinetics and distribution in the human brain. Volkow, N.D., Ding, Y.S., Fowler, J.S., Wang, G.J., Logan, J., Gatley, J.S., Dewey, S., Ashby, C., Liebermann, J., Hitzemann, R. Arch. Gen. Psychiatry (1995) [Pubmed]
  24. Interspecies scaling of the pharmacokinetics of N-nitrosodimethylamine. Gombar, C.T., Harrington, G.W., Pylypiw, H.M., Anderson, L.M., Palmer, A.E., Rice, J.M., Magee, P.N., Burak, E.S. Cancer Res. (1990) [Pubmed]
  25. Pharmacokinetics of oral and intravenous omeprazole in patients with the Zollinger-Ellison syndrome. Vinayek, R., Amantea, M.A., Maton, P.N., Frucht, H., Gardner, J.D., Jensen, R.T. Gastroenterology (1991) [Pubmed]
  26. Effect of granulocyte colony stimulating factor on neutropenia induced by cytotoxic chemotherapy. Morstyn, G., Campbell, L., Souza, L.M., Alton, N.K., Keech, J., Green, M., Sheridan, W., Metcalf, D., Fox, R. Lancet (1988) [Pubmed]
  27. Busulfan pharmacokinetics using a single daily high-dose regimen in children with acute leukemia. Shaw, P.J., Scharping, C.E., Brian, R.J., Earl, J.W. Blood (1994) [Pubmed]
  28. Pharmacokinetics and pharmacodynamics of oral methotrexate and mercaptopurine in children with lower risk acute lymphoblastic leukemia: a joint children's cancer group and pediatric oncology branch study. Balis, F.M., Holcenberg, J.S., Poplack, D.G., Ge, J., Sather, H.N., Murphy, R.F., Ames, M.M., Waskerwitz, M.J., Tubergen, D.G., Zimm, S., Gilchrist, G.S., Bleyer, W.A. Blood (1998) [Pubmed]
  29. L-dopa pharmacokinetics in plasma and cisternal and lumbar cerebrospinal fluid of monkeys. Hammerstad, J.P., Woodward, W.R., Gliessman, P., Boucher, B., Nutt, J.G. Ann. Neurol. (1990) [Pubmed]
  30. Effects of digoxin in infants with congested circulatory state due to a ventricular septal defect. Berman, W., Yabek, S.M., Dillon, T., Niland, C., Corlew, S., Christensen, D. N. Engl. J. Med. (1983) [Pubmed]
  31. Acceleration of the body clearance of phenobarbital by oral activated charcoal. Berg, M.J., Berlinger, W.G., Goldberg, M.J., Spector, R., Johnson, G.F. N. Engl. J. Med. (1982) [Pubmed]
  32. Increased glomerular filtration rate in patients with major burns and its effect on the pharmacokinetics of tobramycin. Loirat, P., Rohan, J., Baillet, A., Beaufils, F., David, R., Chapman, A. N. Engl. J. Med. (1978) [Pubmed]
  33. Digoxin-quinidine interaction Pharmacokinetic evaluation. Hager, W.D., Fenster, P., Mayersohn, M., Perrier, D., Graves, P., Marcus, F.I., Goldman, S. N. Engl. J. Med. (1979) [Pubmed]
  34. Oral flecainide acetate for the treatment of ventricular arrhythmias. Anderson, J.L., Stewart, J.R., Perry, B.A., Van Hamersveld, D.D., Johnson, T.A., Conard, G.J., Chang, S.F., Kvam, D.C., Pitt, B. N. Engl. J. Med. (1981) [Pubmed]
  35. Altered pharmacokinetics of vinblastine in Mdr1a P-glycoprotein-deficient Mice. van Asperen, J., Schinkel, A.H., Beijnen, J.H., Nooijen, W.J., Borst, P., van Tellingen, O. J. Natl. Cancer Inst. (1996) [Pubmed]
  36. Neuroprotection with noninvasive neurotrophin delivery to the brain. Wu, D., Pardridge, W.M. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  37. Phase I and pharmacokinetic study of the novel MDR1 and MRP1 inhibitor biricodar administered alone and in combination with doxorubicin. Peck, R.A., Hewett, J., Harding, M.W., Wang, Y.M., Chaturvedi, P.R., Bhatnagar, A., Ziessman, H., Atkins, F., Hawkins, M.J. J. Clin. Oncol. (2001) [Pubmed]
  38. Explaining interindividual variability of docetaxel pharmacokinetics and pharmacodynamics in Asians through phenotyping and genotyping strategies. Goh, B.C., Lee, S.C., Wang, L.Z., Fan, L., Guo, J.Y., Lamba, J., Schuetz, E., Lim, R., Lim, H.L., Ong, A.B., Lee, H.S. J. Clin. Oncol. (2002) [Pubmed]
  39. Differences of biodistribution, pharmacokinetics, and tumor targeting between interleukins 2 and 15. Kobayashi, H., Carrasquillo, J.A., Paik, C.H., Waldmann, T.A., Tagaya, Y. Cancer Res. (2000) [Pubmed]
  40. Pharmacokinetics of zidovudine in a patient on maintenance hemodialysis. Deray, G., Diquet, B., Martinez, F., Vidal, A.M., Petitclerc, T., Ben Hmida, M., Lana, G., Jacobs, C. N. Engl. J. Med. (1988) [Pubmed]
  41. Development of growth hormone secretagogues. Smith, R.G. Endocr. Rev. (2005) [Pubmed]
  42. Phase I and pharmacologic studies of topotecan in patients with impaired hepatic function. O'Reilly, S., Rowinsky, E., Slichenmyer, W., Donehower, R.C., Forastiere, A., Ettinger, D., Chen, T.L., Sartorius, S., Bowling, K., Smith, J., Brubaker, A., Lubejko, B., Ignacio, V., Grochow, L.B. J. Natl. Cancer Inst. (1996) [Pubmed]
  43. Digoxin pharmacokinetics in continuous peritoneal dialysis. Pancorbo, S., Comty, C. Ann. Intern. Med. (1980) [Pubmed]
  44. On-line analysis of penicillin blood levels in the live rat by combined microdialysis/fast-atom bombardment mass spectrometry. Caprioli, R.M., Lin, S.N. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
WikiGenes - Universities