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MeSH Review

Morphine Dependence

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Psychiatry related information on Morphine Dependence


High impact information on Morphine Dependence

  • Thus, the oxytocin neurons projecting to septum can develop morphine dependence and may be inhibited acutely by opioids acting via mu-receptors [2].
  • The ability of methadone and buprenorphine to desensitize the mu receptor and block the compensatory rise in forskolin-stimulated cAMP accumulation may be an underlying mechanism by which these agents are effective in the treatment of morphine addiction [3].
  • Overexpression of dynamin is induced by chronic stimulation of mu- but not delta-opioid receptors: relationships with mu-related morphine dependence [4].
  • Thus, morphine dependence results in the alteration of diverse, brain region-specific, signal transcription pathways involving AP-1 transcription factors [5].
  • Modulation of anxiety-like behavior and morphine dependence in CREB-deficient mice [6].

Chemical compound and disease context of Morphine Dependence

  • The objective of this study was to establish the effects of prefrontocortical dopamine depletion on opiate withdrawal and prefrontocortical neurochemical changes elicited by morphine dependence and withdrawal [7].
  • The results showed that chronic morphine dependence did not modify basal levels of monoamines in sham rats, revealing neuroadaptation of prefrontocortical dopamine, noradrenaline and serotonin systems to chronic morphine [7].
  • Treatment of rats with cyclic adenosine 3',5'-monophosphate (cAMP), 50 mg/kg intraperitoneally once daily prior to and during induction of morphine dependence and during withdrawal, markedly reduced the appearance of morphine-induced high voltage EEG slow activity after implantation of the morphine pellets [8].
  • Cyclic AMP-induced changes in the electroencephalogram and in behavior during morphine dependence and abstinence in the rat [8].
  • The development of tolerance to the analgesic effects of morphine as well as morphine dependence were greatly reduced by co-administration with morphine of GM1 ganglioside, a substance reported to block the translocation of protein kinase C (PKC) from cytosol to membrane of neurons [9].

Biological context of Morphine Dependence


Anatomical context of Morphine Dependence


Gene context of Morphine Dependence


Analytical, diagnostic and therapeutic context of Morphine Dependence


  1. Revisiting Anna O.: a case of chemical dependence. Ramos, S.d.e. .P. History of psychology. (2003) [Pubmed]
  2. Oxytocin and vasopressin release in discrete brain areas after naloxone in morphine-tolerant and -dependent anesthetized rats: push-pull perfusion study. Russell, J.A., Neumann, I., Landgraf, R. J. Neurosci. (1992) [Pubmed]
  3. Differential opioid agonist regulation of the mouse mu opioid receptor. Blake, A.D., Bot, G., Freeman, J.C., Reisine, T. J. Biol. Chem. (1997) [Pubmed]
  4. Overexpression of dynamin is induced by chronic stimulation of mu- but not delta-opioid receptors: relationships with mu-related morphine dependence. Noble, F., Szücs, M., Kieffer, B., Roques, B.P. Mol. Pharmacol. (2000) [Pubmed]
  5. Precipitated morphine withdrawal stimulates multiple activator protein-1 signaling pathways in rat brain. Couceyro, P., Douglass, J. Mol. Pharmacol. (1995) [Pubmed]
  6. Modulation of anxiety-like behavior and morphine dependence in CREB-deficient mice. Valverde, O., Mantamadiotis, T., Torrecilla, M., Ugedo, L., Pineda, J., Bleckmann, S., Gass, P., Kretz, O., Mitchell, J.M., Schütz, G., Maldonado, R. Neuropsychopharmacology (2004) [Pubmed]
  7. Behavioral expression of opiate withdrawal is altered after prefrontocortical dopamine depletion in rats: monoaminergic correlates. Espejo, E.F., Serrano, M.I., Caillé, S., Stinus, L. Neuropsychopharmacology (2001) [Pubmed]
  8. Cyclic AMP-induced changes in the electroencephalogram and in behavior during morphine dependence and abstinence in the rat. Shahid Salles, K.S., Colasanti, B.K., Craig, C.R. Sleep. (1979) [Pubmed]
  9. The development of morphine tolerance and dependence is associated with translocation of protein kinase C. Mayer, D.J., Mao, J., Price, D.D. Pain (1995) [Pubmed]
  10. Prolonged morphine treatment increases rat brain dihydropyridine binding sites: possible involvement in development of morphine dependence. Ramkumar, V., el-Fakahany, E.E. Eur. J. Pharmacol. (1988) [Pubmed]
  11. Changes in adenosine receptors mediating hypotension in morphine-dependent rats. White, P.J., Rose'Meyer, R.B., Hope, W. Eur. J. Pharmacol. (1995) [Pubmed]
  12. Endogenous cannabinoid, 2-arachidonoylglycerol, attenuates naloxone-precipitated withdrawal signs in morphine-dependent mice. Yamaguchi, T., Hagiwara, Y., Tanaka, H., Sugiura, T., Waku, K., Shoyama, Y., Watanabe, S., Yamamoto, T. Brain Res. (2001) [Pubmed]
  13. IRAS, a candidate for I1-imidazoline receptor, mediates inhibitory effect of agmatine on cellular morphine dependence. Wu, N., Su, R.B., Xu, B., Lu, X.Q., Liu, Y., Zheng, J.Q., Piletz, J.E., Li, J., Qin, B.Y. Biochem. Pharmacol. (2005) [Pubmed]
  14. Co-treatment with MK-801 potentiates naloxone-precipitated morphine withdrawal in the isolated spinal cord of the neonatal rat. Bell, J.A., Beglan, C.L. Eur. J. Pharmacol. (1995) [Pubmed]
  15. Noradrenergic and dopaminergic activity in the hypothalamic paraventricular nucleus after naloxone-induced morphine withdrawal. Fuertes, G., Laorden, M.L., Milanés, M.V. Neuroendocrinology (2000) [Pubmed]
  16. Release of oxytocin but not corticotrophin-releasing factor-41 into rat hypophysial portal vessel blood can be made opiate dependent. Sheward, W.J., Coombes, J.E., Bicknell, R.J., Fink, G., Russell, J.A. J. Endocrinol. (1990) [Pubmed]
  17. The role of mPer1 in morphine dependence in mice. Liu, Y., Wang, Y., Wan, C., Zhou, W., Peng, T., Liu, Y., Wang, Z., Li, G., Cornelisson, G., Halberg, F. Neuroscience (2005) [Pubmed]
  18. Effect of gene transfer of GLT-1, a glutamate transporter, into the locus coeruleus by recombinant adenoviruses on morphine physical dependence in rats. Ozawa, T., Nakagawa, T., Sekiya, Y., Minami, M., Satoh, M. Eur. J. Neurosci. (2004) [Pubmed]
  19. Prevention by the 5-HT3 receptor antagonist, ondansetron, of morphine-dependence and tolerance in the rat. Hui, S.C., Sevilla, E.L., Ogle, C.W. Br. J. Pharmacol. (1996) [Pubmed]
  20. Differential roles of corticotropin-releasing factor receptor subtypes 1 and 2 in opiate withdrawal and in relapse to opiate dependence. Lu, L., Liu, D., Ceng, X., Ma, L. Eur. J. Neurosci. (2000) [Pubmed]
  21. Reduction of morphine dependence and potentiation of analgesia by chronic co-administration of nifedipine. Antkiewicz-Michaluk, L., Michaluk, J., Romańska, I., Vetulani, J. Psychopharmacology (Berl.) (1993) [Pubmed]
  22. Proteomic analysis of phosphotyrosyl proteins in morphine-dependent rat brains. Kim, S.Y., Chudapongse, N., Lee, S.M., Levin, M.C., Oh, J.T., Park, H.J., Ho, I.K. Brain Res. Mol. Brain Res. (2005) [Pubmed]
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