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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Lymphoma


Psychiatry related information on Lymphoma


High impact information on Lymphoma

  • Understanding how specificity is achieved in PI3K signaling is of particular significance because altered regulation of this pathway is observed in many disease states, including leukemia and lymphoma [11].
  • Mice inheriting two copies of this mutation (Trp53(515C/515C)) escape the early onset of thymic lymphomas that characterize Trp53-null mice [12].
  • Mice deficient for both H2AX and p53 (H(delta/delta)P(-/-)) rapidly developed immature T and B lymphomas and solid tumors [13].
  • We show that MYC, BCL and immunoglobulin loci, which are recurrently translocated in various B-cell lymphomas, are preferentially positioned in close spatial proximity relative to each other in normal B cells [14].
  • We show that pro-B lymphomas in mice deficient for both p53 and nonhomologous end-joining (NHEJ) contain complicons that coamplify c-myc (chromosome 15) and IgH (chromosome 12) sequences [15].

Chemical compound and disease context of Lymphoma


Biological context of Lymphoma


Anatomical context of Lymphoma


Gene context of Lymphoma


Analytical, diagnostic and therapeutic context of Lymphoma


  1. Chromosomal translocations in lymphoid malignancies reveal novel proto-oncogenes. Korsmeyer, S.J. Annu. Rev. Immunol. (1992) [Pubmed]
  2. Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis. Baker, S.M., Bronner, C.E., Zhang, L., Plug, A.W., Robatzek, M., Warren, G., Elliott, E.A., Yu, J., Ashley, T., Arnheim, N., Flavell, R.A., Liskay, R.M. Cell (1995) [Pubmed]
  3. Point mutations in the c-Myc transactivation domain are common in Burkitt's lymphoma and mouse plasmacytomas. Bhatia, K., Huppi, K., Spangler, G., Siwarski, D., Iyer, R., Magrath, I. Nat. Genet. (1993) [Pubmed]
  4. Epstein-Barr virus and a cellular signaling pathway in lymphomas from immunosuppressed patients. Liebowitz, D. N. Engl. J. Med. (1998) [Pubmed]
  5. Reversible lymphoma in the setting of azathioprine therapy for Crohn's disease. Larvol, L., Soule, J.C., Le Tourneau, A. N. Engl. J. Med. (1994) [Pubmed]
  6. The human BCL6 transgene promotes the development of lymphomas in the mouse. Baron, B.W., Anastasi, J., Montag, A., Huo, D., Baron, R.M., Karrison, T., Thirman, M.J., Subudhi, S.K., Chin, R.K., Felsher, D.W., Fu, Y.X., McKeithan, T.W., Baron, J.M. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  7. Radioimmunotherapy of relapsed B-cell lymphoma with yttrium 90 anti-idiotype monoclonal antibodies. White, C.A., Halpern, S.E., Parker, B.A., Miller, R.A., Hupf, H.B., Shawler, D.L., Collins, H.A., Royston, I. Blood (1996) [Pubmed]
  8. The mutation without children(rgl) causes ecdysteroid deficiency in third-instar larvae of Drosophila melanogaster. Wismar, J., Habtemichael, N., Warren, J.T., Dai, J.D., Gilbert, L.I., Gateff, E. Dev. Biol. (2000) [Pubmed]
  9. Enhancement of hippocampal neurogenesis by lithium. Chen, G., Rajkowska, G., Du, F., Seraji-Bozorgzad, N., Manji, H.K. J. Neurochem. (2000) [Pubmed]
  10. Busulfan, cyclophosphamide and etoposide as high-dose conditioning therapy in patients with malignant lymphoma and prior dose-limiting radiation therapy. Kröger, N., Hoffknecht, M., Hänel, M., Krüger, W., Zeller, W., Stockschläder, M., de Wit, M., Weh, H.J., Kabisch, H., Erttmann, R., Zander, A.R. Bone Marrow Transplant. (1998) [Pubmed]
  11. Phosphoinositide 3-kinase: diverse roles in immune cell activation. Deane, J.A., Fruman, D.A. Annu. Rev. Immunol. (2004) [Pubmed]
  12. Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice. Liu, G., Parant, J.M., Lang, G., Chau, P., Chavez-Reyes, A., El-Naggar, A.K., Multani, A., Chang, S., Lozano, G. Nat. Genet. (2004) [Pubmed]
  13. Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors. Bassing, C.H., Suh, H., Ferguson, D.O., Chua, K.F., Manis, J., Eckersdorff, M., Gleason, M., Bronson, R., Lee, C., Alt, F.W. Cell (2003) [Pubmed]
  14. Spatial proximity of translocation-prone gene loci in human lymphomas. Roix, J.J., McQueen, P.G., Munson, P.J., Parada, L.A., Misteli, T. Nat. Genet. (2003) [Pubmed]
  15. Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations. Zhu, C., Mills, K.D., Ferguson, D.O., Lee, C., Manis, J., Fleming, J., Gao, Y., Morton, C.C., Alt, F.W. Cell (2002) [Pubmed]
  16. Two-dimensional gel analysis of cyclic AMP effects in cultured S49 mouse lymphoma cells: protein modifications, inductions and repressions. Steinberg, R.A., Coffino, P. Cell (1979) [Pubmed]
  17. The mouse T cell receptor: structural heterogeneity of molecules of normal T cells defined by xenoantiserum. McIntyre, B.W., Allison, J.P. Cell (1983) [Pubmed]
  18. Mutations causing charge alterations in regulatory subunits of the cAMP-dependent protein kinase of cultured S49 lymphoma cells. Steinberg, R.A., O'Farrell, P.H., Friedrich, U., Coffino, P. Cell (1977) [Pubmed]
  19. Abnormal lipid-linked oligosaccharides in class E Thy-1-negative mutant lymphomas. Trowbridge, I.S., Hyman, R. Cell (1979) [Pubmed]
  20. Deoxyadenosine metabolism and cytotoxicity in cultured mouse T lymphoma cells: a model for immunodeficiency disease. Ullman, B., Gudas, L.J., Cohen, A., Martin, D.W. Cell (1978) [Pubmed]
  21. Proteins encoded by v-myc and c-myc oncogenes: identification and localization in acute leukemia virus transformants and bursal lymphoma cell lines. Hann, S.R., Abrams, H.D., Rohrschneider, L.R., Eisenman, R.N. Cell (1983) [Pubmed]
  22. Role of the octamer motif in hybrid cell extinction of immunoglobulin gene expression: extinction is dominant in a two enhancer system. Yu, H., Porton, B., Shen, L.Y., Eckhardt, L.A. Cell (1989) [Pubmed]
  23. FGFR1 is fused with a novel zinc-finger gene, ZNF198, in the t(8;13) leukaemia/lymphoma syndrome. Xiao, S., Nalabolu, S.R., Aster, J.C., Ma, J., Abruzzo, L., Jaffe, E.S., Stone, R., Weissman, S.M., Hudson, T.J., Fletcher, J.A. Nat. Genet. (1998) [Pubmed]
  24. Clustering of missense mutations in the ataxia-telangiectasia gene in a sporadic T-cell leukaemia. Vorechovský, I., Luo, L., Dyer, M.J., Catovsky, D., Amlot, P.L., Yaxley, J.C., Foroni, L., Hammarström, L., Webster, A.D., Yuille, M.A. Nat. Genet. (1997) [Pubmed]
  25. Epstein-Barr virus-induced B-cell lymphoma after renal transplantation: acyclovir therapy and transition from polyclonal to monoclonal B-cell proliferation. Hanto, D.W., Frizzera, G., Gajl-Peczalska, K.J., Sakamoto, K., Purtilo, D.T., Balfour, H.H., Simmons, R.L., Najarian, J.S. N. Engl. J. Med. (1982) [Pubmed]
  26. Different lymphoid cell targets by transformation by replication-competent Moloney and Rauscher mouse leukemia viruses. Reddy, E.P., Dunn, C.Y., Aaronson, S.A. Cell (1980) [Pubmed]
  27. Lack of BCL10 mutations in germ cell tumors and B cell lymphomas. Fakruddin, J.M., Chaganti, R.S., Murty, V.V. Cell (1999) [Pubmed]
  28. Expression of J chain RNA in cell lines representing different stages of B lymphocyte differentiation. Mather, E.L., Alt, F.W., Bothwell, A.L., Baltimore, D., Koshland, M.E. Cell (1981) [Pubmed]
  29. HNPCC-like cancer predisposition in mice through simultaneous loss of Msh3 and Msh6 mismatch-repair protein functions. de Wind, N., Dekker, M., Claij, N., Jansen, L., van Klink, Y., Radman, M., Riggins, G., van der Valk, M., van't Wout, K., te Riele, H. Nat. Genet. (1999) [Pubmed]
  30. Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer. de Wind, N., Dekker, M., Berns, A., Radman, M., te Riele, H. Cell (1995) [Pubmed]
  31. Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types. Willis, T.G., Jadayel, D.M., Du, M.Q., Peng, H., Perry, A.R., Abdul-Rauf, M., Price, H., Karran, L., Majekodunmi, O., Wlodarska, I., Pan, L., Crook, T., Hamoudi, R., Isaacson, P.G., Dyer, M.J. Cell (1999) [Pubmed]
  32. Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target. Chiarle, R., Simmons, W.J., Cai, H., Dhall, G., Zamo, A., Raz, R., Karras, J.G., Levy, D.E., Inghirami, G. Nat. Med. (2005) [Pubmed]
  33. Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells. Polo, J.M., Dell'Oso, T., Ranuncolo, S.M., Cerchietti, L., Beck, D., Da Silva, G.F., Prive, G.G., Licht, J.D., Melnick, A. Nat. Med. (2004) [Pubmed]
  34. HIV-1 induction of CD40 on endothelial cells promotes the outgrowth of AIDS-associated B-cell lymphomas. Moses, A.V., Williams, S.E., Strussenberg, J.G., Heneveld, M.L., Ruhl, R.A., Bakke, A.C., Bagby, G.C., Nelson, J.A. Nat. Med. (1997) [Pubmed]
  35. Aberrant V(D)J recombination is not required for rapid development of H2ax/p53-deficient thymic lymphomas with clonal translocations. Bassing, C.H., Ranganath, S., Murphy, M., Savic, V., Gleason, M., Alt, F.W. Blood (2008) [Pubmed]
  36. CXCL13 and CXCL12 in central nervous system lymphoma patients. Fischer, L., Korfel, A., Pfeiffer, S., Kiewe, P., Volk, H.D., Cakiroglu, H., Widmann, T., Thiel, E. Clin. Cancer Res. (2009) [Pubmed]
  37. A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy. Schmitt, C.A., Fridman, J.S., Yang, M., Lee, S., Baranov, E., Hoffman, R.M., Lowe, S.W. Cell (2002) [Pubmed]
  38. Diagnosis of leukemia or lymphoma in the central nervous system by beta 2-microglobulin determination. Mavlight, G.M., Stuckey, S.E., Cabanillas, F.F., Keating, M.J., Tourtellotte, W.W., Schold, S.C., Freireich, E.J. N. Engl. J. Med. (1980) [Pubmed]
  39. T-cell lymphoma induction by radiation leukemia virus in athymic nude mice. Ricciardi-Castagnoli, P., Lieberman, M., Finn, O., Kaplan, H.S. J. Exp. Med. (1978) [Pubmed]
  40. Cytolytic T cell granules. Isolation, structural, biochemical, and functional characterization. Podack, E.R., Konigsberg, P.J. J. Exp. Med. (1984) [Pubmed]
  41. Extracellular cytolysis by activated macrophages and granulocytes. I. Pharmacologic triggering of effector cells and the release of hydrogen peroxide. Nathan, C.F., Brukner, L.H., Silverstein, S.C., Cohn, Z.A. J. Exp. Med. (1979) [Pubmed]
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