Disease relevance of Eyelashes

• The most prominent features present in the male patients were follicular hyperkeratosis, hyperkeratosis of the calcaneal regions of the soles, scarring alopecia of the scalp, absence of eyebrows and eyelashes, and corneal dystrophy accompanied by photophobia [1].
• Clinical signs were microcephaly, hemangiomata, long incurved eyelashes, strabismus, enlarged bridge of the nose, abnormally long philtrum, high-arched palate, low set ears, hexadactyly of the four extremities, umbilical and inguinal hernias, neonatal respiratory distress, psychomotor and growth retardation [2].
• Both patients had severe hypospadias, large fontanelles, cleft palate, and minor facial anomalies (square and prominent forehead, short, downslanting palpebral fissures, long eyelashes, long philtrum, short nose, thin vermilion border with downcurved upper lip) [3].
• RESULTS: In 43 patients receiving unilateral topical latanoprost, hypertrichosis involved ipsilateral terminal eyelashes and regional intermediate hairs of the upper and lower eyelid as well as vellus hair of the lower eyelid skin [4].
• Data from spontaneous reporting systems support a possible association of decreased vision, cystoid macular oedema, sicca-like symptoms, discoloration of the eyelids with or without periorbital or eyelid oedema, proptosis, loss of eyebrow or eyelashes, and superficial punctate keratitis with the use of niacin in high doses [5].

High impact information on Eyelashes

• Excessive growth of eyelashes in a patient with AIDS being treated with zidovudine [6].
• However, most children with TCS present with the following classic facial features: down-sloping palpebral fissures, colobomata of the lower eyelid, scanty lower eyelashes, malar hypoplasia, and micro- or retrognathia [7].
• Latanoprost reversed alopecia of the eyelashes in one patient [8].
• Loss of eyelashes after use of a tinting mascara containing PPD [9].
• RESULTS: Ophthalmic examination disclosed a best-corrected visual acuity of right eye (RE): 20/25 and left eye (LE): 20/50, burned eyelashes, punctate keratitis, iridocyclitis, anterior subcapsular lens opacity, missing foveolar reflex, and macular pigment epithelial defect LE [10].

Chemical compound and disease context of Eyelashes

• Allergic contact dermatitis from 2-chloro-p-phenylenediamine in a cream dye for eyelashes and eyebrows [11].
• The most important adverse events for the prostaglandin derivatives were conjunctival hyperemia, eyelashes pigmentation and growth, iris pigmentation [12].

Biological context of Eyelashes

• It was interesting to find an association of AFA with hypoplasia of hair, eyelashes, eyebrows and nails and a karyotype of trisomy 18 in this case [13].

Anatomical context of Eyelashes

• We describe an 18-year-old girl with a distinctive facial appearence, almost complete absence of the scalp and body hair, absence of the eyebrows and eyelashes, oligodontia, conically shaped maxillary central incisors and zygodactylous palmar triradii suggesting for syndactyly type I [14].

Associations of Eyelashes with chemical compounds

• Patients should be educated on adverse events associated with prostaglandin analogs, particularly the potential for changes in the pigmentation of the iris and eyelashes [15].
• Retinal evaluation after 810 nm Dioderm laser removal of eyelashes [16].
• Pyrocatechol contact allergy from a permanent cream dye for eyelashes and eyebrows [17].
• Bimatoprost has been reported to cause changes in the pigmentation of the periorbital skin, eyelashes and iris, and increase eyelash growth [18].
• The eyelashes were treated by application of the permethrin solution with a cotton-tip swab [19].

Gene context of Eyelashes

• Clinical examination revealed features suggestive of Kabuki syndrome including large, prominent ears, sparse, medially flared and arched eyebrows, wide palpebral fissures, long eyelashes, and oligodontia with flat head 'screwdriver-shaped' incisors, in addition to persistent finger and thumb-tip pads [20].
• Leaf-shaped lesions of ocular fundus and white eyelashes in tuberous sclerosis [21].
• Unilateral poliosis of the eyelashes in children associated with vitiligo [22].
• We describe a brother and sister with retinitis pigmentosa (RP), growth failure, long eyelashes, and sparse hair [23].
• White eyelashes, seen only in our cases, may be a sign of "early senility." CONCLUSIONS: Optic atrophy is not a constant finding in GAPO syndrome [24].

References