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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Macrophages

 
 
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Disease relevance of Macrophages

 

Psychiatry related information on Macrophages

 

High impact information on Macrophages

  • Interleukin-10 (IL-10), first recognized for its ability to inhibit activation and effector function of T cells, monocytes, and macrophages, is a multifunctional cytokine with diverse effects on most hemopoietic cell types [11].
  • In order to discriminate between infectious agents and self, macrophages have evolved a restricted number of phagocytic receptors, like the mannose receptor, that recognize conserved motifs on pathogens [12].
  • Expression of NOS2 in macrophages is controlled by cytokines and microbial products, primarily by transcriptional induction [13].
  • NOS2 has been documented in macrophages from human, horse, cow, goat, sheep, rat, mouse, and chicken [13].
  • A counter-receptor for CD28 is the B7 molecule expressed on activated B cells, dendritic cells, and macrophages [14].
 

Chemical compound and disease context of Macrophages

 

Biological context of Macrophages

 

Anatomical context of Macrophages

 

Associations of Macrophages with chemical compounds

 

Gene context of Macrophages

  • Subcellular fractionation of LPS-stimulated macrophages revealed that LPS signals transduced by Tpl2 specifically promote the transport of TNF-alpha mRNA from the nucleus to the cytoplasm [34].
  • Expression of Ucp2 is robust in spleen, lung and isolated macrophages, suggesting a role for Ucp2 in immunity or inflammatory responsiveness [35].
  • We also show that LeTx-induced macrophage death requires caspase-1, which is activated in susceptible, but not resistant, macrophages after intoxication, suggesting that Nalp1b directly or indirectly activates caspase-1 in response to LeTx [36].
  • Compared to UCP1, the gene is widely expressed in adult human tissues, including tissues rich in macrophages, and it is upregulated in white fat in response to fat feeding [37].
  • Wild-type choroidal macrophages degrade C5 and IgG in eye sections of Ccl2(-/-) or Ccr2(-/-) mice [38].
 

Analytical, diagnostic and therapeutic context of Macrophages

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