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MeSH Review

Second Messenger Systems

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Disease relevance of Second Messenger Systems


Psychiatry related information on Second Messenger Systems


High impact information on Second Messenger Systems


Chemical compound and disease context of Second Messenger Systems


Biological context of Second Messenger Systems


Anatomical context of Second Messenger Systems


Associations of Second Messenger Systems with chemical compounds


Gene context of Second Messenger Systems


Analytical, diagnostic and therapeutic context of Second Messenger Systems


  1. Nerve growth factor and fibroblast growth factor regulate neurite outgrowth and gene expression in PC12 cells via both protein kinase C- and cAMP-independent mechanisms. Damon, D.H., D'Amore, P.A., Wagner, J.A. J. Cell Biol. (1990) [Pubmed]
  2. Angiotensin II modulates cardiac Na+ channels in neonatal rat. Moorman, J.R., Kirsch, G.E., Lacerda, A.E., Brown, A.M. Circ. Res. (1989) [Pubmed]
  3. Lysophosphatidic acid opens a Ca(++) channel in human erythrocytes. Yang, L., Andrews, D.A., Low, P.S. Blood (2000) [Pubmed]
  4. Effector function for RAS oncogene in interleukin-3-dependent myeloid cells involves diminished efficacy of prostaglandin E1-mediated inhibition of proliferation. Derigs, H.G., Klingberg, D., Tricot, G.J., Boswell, H.S. Blood (1989) [Pubmed]
  5. Nitric oxide signaling in pain and nociceptor sensitization in the rat. Aley, K.O., McCarter, G., Levine, J.D. J. Neurosci. (1998) [Pubmed]
  6. Cyclic nucleotide- and inositol phosphate-gated ion channels in lobster olfactory receptor neurons. Hatt, H., Ache, B.W. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  7. Ceramide stabilizes beta-site amyloid precursor protein-cleaving enzyme 1 and promotes amyloid beta-peptide biogenesis. Puglielli, L., Ellis, B.C., Saunders, A.J., Kovacs, D.M. J. Biol. Chem. (2003) [Pubmed]
  8. Inositol trisphosphate, cyclic AMP, and cyclic GMP in rat brain regions after lithium and seizures. Jope, R.S., Song, L., Kolasa, K. Biol. Psychiatry (1992) [Pubmed]
  9. Increased G alpha q/11 immunoreactivity in postmortem occipital cortex from patients with bipolar affective disorder. Mathews, R., Li, P.P., Young, L.T., Kish, S.J., Warsh, J.J. Biol. Psychiatry (1997) [Pubmed]
  10. Changes in the second messenger cyclic AMP during development may underlie motoric symptoms in attention deficit/hyperactivity disorder (ADHD). Andersen, S.L. Behav. Brain Res. (2002) [Pubmed]
  11. Phosphoinositide 3-kinase: diverse roles in immune cell activation. Deane, J.A., Fruman, D.A. Annu. Rev. Immunol. (2004) [Pubmed]
  12. Inositol 1,4,5-trisphosphate receptors as signal integrators. Patterson, R.L., Boehning, D., Snyder, S.H. Annu. Rev. Biochem. (2004) [Pubmed]
  13. PTEN and myotubularin: novel phosphoinositide phosphatases. Maehama, T., Taylor, G.S., Dixon, J.E. Annu. Rev. Biochem. (2001) [Pubmed]
  14. Synthesis and function of 3-phosphorylated inositol lipids. Vanhaesebroeck, B., Leevers, S.J., Ahmadi, K., Timms, J., Katso, R., Driscoll, P.C., Woscholski, R., Parker, P.J., Waterfield, M.D. Annu. Rev. Biochem. (2001) [Pubmed]
  15. Receptor density determines secretory response patterns mediate by inositol lipid-derived second messengers. Comparison of thyrotropin-releasing hormone and carbamylcholine actions in thyroid-stimulating hormone-secreting mouse pituitary tumor cells. Winicov, I., Gershengorn, M.C. J. Biol. Chem. (1989) [Pubmed]
  16. Role of phosphoinositide-derived second messengers in mediating anti-IgM-induced growth arrest of WEHI-231 B lymphoma cells. Page, D.M., DeFranco, A.L. J. Immunol. (1988) [Pubmed]
  17. Genome-wide transcriptional profile of Escherichia coli in response to high levels of the second messenger 3',5'-cyclic diguanylic acid. Méndez-Ortiz, M.M., Hyodo, M., Hayakawa, Y., Membrillo-Hernández, J. J. Biol. Chem. (2006) [Pubmed]
  18. Soy protein and serum lipids. Potter, S.M. Curr. Opin. Lipidol. (1996) [Pubmed]
  19. Sphingolipids signal heat stress-induced ubiquitin-dependent proteolysis. Chung, N., Jenkins, G., Hannun, Y.A., Heitman, J., Obeid, L.M. J. Biol. Chem. (2000) [Pubmed]
  20. Transcriptional regulation by cyclic AMP. Montminy, M. Annu. Rev. Biochem. (1997) [Pubmed]
  21. Ceramide synthase mediates daunorubicin-induced apoptosis: an alternative mechanism for generating death signals. Bose, R., Verheij, M., Haimovitz-Friedman, A., Scotto, K., Fuks, Z., Kolesnick, R. Cell (1995) [Pubmed]
  22. Inositol trisphosphate, a novel second messenger in cellular signal transduction. Berridge, M.J., Irvine, R.F. Nature (1984) [Pubmed]
  23. FMRFamide reverses protein phosphorylation produced by 5-HT and cAMP in Aplysia sensory neurons. Sweatt, J.D., Volterra, A., Edmonds, B., Karl, K.A., Siegelbaum, S.A., Kandel, E.R. Nature (1989) [Pubmed]
  24. Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Verheij, M., Bose, R., Lin, X.H., Yao, B., Jarvis, W.D., Grant, S., Birrer, M.J., Szabo, E., Zon, L.I., Kyriakis, J.M., Haimovitz-Friedman, A., Fuks, Z., Kolesnick, R.N. Nature (1996) [Pubmed]
  25. Functional interaction between InsP3 receptors and store-operated Htrp3 channels. Kiselyov, K., Xu, X., Mozhayeva, G., Kuo, T., Pessah, I., Mignery, G., Zhu, X., Birnbaumer, L., Muallem, S. Nature (1998) [Pubmed]
  26. Ion channels activated by inositol 1,4,5-trisphosphate in plasma membrane of human T-lymphocytes. Kuno, M., Gardner, P. Nature (1987) [Pubmed]
  27. Local calcium signalling by inositol-1,4,5-trisphosphate in Purkinje cell dendrites. Finch, E.A., Augustine, G.J. Nature (1998) [Pubmed]
  28. Alternative splicing of C-terminal tail of prostaglandin E receptor subtype EP3 determines G-protein specificity. Namba, T., Sugimoto, Y., Negishi, M., Irie, A., Ushikubi, F., Kakizuka, A., Ito, S., Ichikawa, A., Narumiya, S. Nature (1993) [Pubmed]
  29. Injection of the cAMP-responsive element into the nucleus of Aplysia sensory neurons blocks long-term facilitation. Dash, P.K., Hochner, B., Kandel, E.R. Nature (1990) [Pubmed]
  30. Regulation of eukaryotic phosphatidylinositol-specific phospholipase C and phospholipase D. Singer, W.D., Brown, H.A., Sternweis, P.C. Annu. Rev. Biochem. (1997) [Pubmed]
  31. Inositol trisphosphate and diacylglycerol: two interacting second messengers. Berridge, M.J. Annu. Rev. Biochem. (1987) [Pubmed]
  32. Receptors and phosphoinositide-generated second messengers. Hokin, L.E. Annu. Rev. Biochem. (1985) [Pubmed]
  33. Transduction mechanisms in vertebrate olfactory receptor cells. Schild, D., Restrepo, D. Physiol. Rev. (1998) [Pubmed]
  34. Adaptation in vertebrate photoreceptors. Fain, G.L., Matthews, H.R., Cornwall, M.C., Koutalos, Y. Physiol. Rev. (2001) [Pubmed]
  35. Morphoregulatory activities of NCAM and N-cadherin can be accounted for by G protein-dependent activation of L- and N-type neuronal Ca2+ channels. Doherty, P., Ashton, S.V., Moore, S.E., Walsh, F.S. Cell (1991) [Pubmed]
  36. Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1. Krylova, I.N., Sablin, E.P., Moore, J., Xu, R.X., Waitt, G.M., MacKay, J.A., Juzumiene, D., Bynum, J.M., Madauss, K., Montana, V., Lebedeva, L., Suzawa, M., Williams, J.D., Williams, S.P., Guy, R.K., Thornton, J.W., Fletterick, R.J., Willson, T.M., Ingraham, H.A. Cell (2005) [Pubmed]
  37. A minK-HERG complex regulates the cardiac potassium current I(Kr). McDonald, T.V., Yu, Z., Ming, Z., Palma, E., Meyers, M.B., Wang, K.W., Goldstein, S.A., Fishman, G.I. Nature (1997) [Pubmed]
  38. The prolactin/growth hormone receptor family. Kelly, P.A., Djiane, J., Postel-Vinay, M.C., Edery, M. Endocr. Rev. (1991) [Pubmed]
  39. The heme oxygenase system: a regulator of second messenger gases. Maines, M.D. Annu. Rev. Pharmacol. Toxicol. (1997) [Pubmed]
  40. G protein antagonists. Freissmuth, M., Waldhoer, M., Bofill-Cardona, E., Nanoff, C. Trends Pharmacol. Sci. (1999) [Pubmed]
  41. Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily. Jones, P.F., Jakubowicz, T., Pitossi, F.J., Maurer, F., Hemmings, B.A. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  42. Ligation of the CD44 adhesion molecule inhibits drug-induced apoptosis in human myeloid leukemia cells. Allouche, M., Charrad, R.S., Bettaieb, A., Greenland, C., Grignon, C., Smadja-Joffe, F. Blood (2000) [Pubmed]
  43. Localization of adenylyl and guanylyl cyclase in rat brain by in situ hybridization: comparison with calmodulin mRNA distribution. Matsuoka, I., Giuili, G., Poyard, M., Stengel, D., Parma, J., Guellaen, G., Hanoune, J. J. Neurosci. (1992) [Pubmed]
  44. Phospholipase A2 treatment of lymphocytes provides helper signal for interferon-gamma induction. Evidence for second messenger role of endogenous arachidonic acid. Russell, J.K., Torres, B.A., Johnson, H.M. J. Immunol. (1987) [Pubmed]
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