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MeSH Review

Cell Division

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Disease relevance of Cell Division


Psychiatry related information on Cell Division


High impact information on Cell Division

  • The Janus family of protein tyrosine kinases (JAKs) and STAT transcription factors regulate cellular processes involved in cell growth, differentiation, and transformation through their association with cytokine receptors [11].
  • Return of the GDI: the GoLoco motif in cell division [12].
  • Surprisingly, many signal transduction proteins are dynamically localized to specific subcellular addresses during the cell division cycle and sporulation, and proper localization is essential for their function [13].
  • This inositol lipid is an important regulator of cell growth and survival signaling through the Ser/Thr protein kinases PDK1 and Akt [14].
  • G protein-mediated signaling is employed by virtually all cells in the mammalian organism and is centrally involved in diverse physiological functions such as perception of sensory information, modulation of synaptic transmission, hormone release and actions, regulation of cell contraction and migration, or cell growth and differentiation [15].

Chemical compound and disease context of Cell Division


Biological context of Cell Division


Anatomical context of Cell Division


Associations of Cell Division with chemical compounds


Gene context of Cell Division

  • Whereas loss of RB function is associated with the loss of cellular proliferative control, introduction of a wild-type RB can suppress cell growth and tumorigenicity [36].
  • TSC2 mediates cellular energy response to control cell growth and survival [37].
  • We demonstrate that prospero RNA is also asymmetrically localized and partitioned during neuroblast cell divisions, a process requiring both inscuteable and staufen [38].
  • However, p72 directly associates with cdc2-cyclin B in a cell cycle-dependent manner, reaching a peak at M phase [39].
  • Unlike most cdc mutants, which continue to grow in the absence of cell division, PKC1-depleted cells arrested growth with small buds [40].

Analytical, diagnostic and therapeutic context of Cell Division

  • Furthermore, we find that about 5% of splenic DCs are undergoing cell division, and the number of dividing CD8- DCs is disproportionately reduced in the absence of the LT beta R. In parabiosis experiments, splenic DCs were only partially replaced by circulating precursors over a 6 week period [41].
  • G6Pase mRNA peaks at 30 min and 36-48 h after hepatectomy correlating with the first and second rounds of cell division [42].
  • Using a specific and very sensitive (1 pg = 1 U) bioassay, we investigated the presence of IL-6, a potent myeloma cell growth factor, in the sera of 131 subjects with plasma cell dyscrasias [43].
  • My hypothesis is that cholesterol inhibition can inhibit tumour cell growth, can act as an adjuvant to cancer chemotherapy, and, possibly, can prevent carcinogenesis [44].
  • Polymerase beta is not detected by immunofluorescence either during cell division or G1, but is abruptly detected in the antipodal sites at the onset of kDNA replication [45].


  1. Nuclear actin and actin-related proteins in chromatin remodeling. Olave, I.A., Reck-Peterson, S.L., Crabtree, G.R. Annu. Rev. Biochem. (2002) [Pubmed]
  2. The developmental pattern of Brca1 expression implies a role in differentiation of the breast and other tissues. Marquis, S.T., Rajan, J.V., Wynshaw-Boris, A., Xu, J., Yin, G.Y., Abel, K.J., Weber, B.L., Chodosh, L.A. Nat. Genet. (1995) [Pubmed]
  3. Expression of an extracellular deletion of Xotch diverts cell fate in Xenopus embryos. Coffman, C.R., Skoglund, P., Harris, W.A., Kintner, C.R. Cell (1993) [Pubmed]
  4. Cystic fibrosis hetero- and homozygosity is associated with inhibition of breast cancer growth. Abraham, E.H., Vos, P., Kahn, J., Grubman, S.A., Jefferson, D.M., Ding, I., Okunieff, P. Nat. Med. (1996) [Pubmed]
  5. Escherichia coli cell-division gene ftsZ encodes a novel GTP-binding protein. RayChaudhuri, D., Park, J.T. Nature (1992) [Pubmed]
  6. The cell cycle Cdc25A tyrosine phosphatase is activated in degenerating postmitotic neurons in Alzheimer's disease. Ding, X.L., Husseman, J., Tomashevski, A., Nochlin, D., Jin, L.W., Vincent, I. Am. J. Pathol. (2000) [Pubmed]
  7. MIDA1, a protein associated with Id, regulates cell growth. Shoji, W., Inoue, T., Yamamoto, T., Obinata, M. J. Biol. Chem. (1995) [Pubmed]
  8. Development and application of bioprobes for Mammalian cell cycle analyses. Osada, H. Current medicinal chemistry. (2003) [Pubmed]
  9. Multiple signalling pathways establish cell fate and cell number in Drosophila malpighian tubules. Wan, S., Cato, A.M., Skaer, H. Dev. Biol. (2000) [Pubmed]
  10. Kinetics and bioenergetics of Spirulina platensis cultivation by fed-batch addition of urea as nitrogen source. Sassano, C.E., Carvalho, J.C., Gioielli, L.A., Sato, S., Torre, P., Converti, A. Appl. Biochem. Biotechnol. (2004) [Pubmed]
  11. Negative regulation of cytokine signaling pathways. Yasukawa, H., Sasaki, A., Yoshimura, A. Annu. Rev. Immunol. (2000) [Pubmed]
  12. Return of the GDI: the GoLoco motif in cell division. Willard, F.S., Kimple, R.J., Siderovski, D.P. Annu. Rev. Biochem. (2004) [Pubmed]
  13. Temporal and spatial regulation in prokaryotic cell cycle progression and development. Ryan, K.R., Shapiro, L. Annu. Rev. Biochem. (2003) [Pubmed]
  14. PTEN and myotubularin: novel phosphoinositide phosphatases. Maehama, T., Taylor, G.S., Dixon, J.E. Annu. Rev. Biochem. (2001) [Pubmed]
  15. Mammalian G proteins and their cell type specific functions. Wettschureck, N., Offermanns, S. Physiol. Rev. (2005) [Pubmed]
  16. Cyclic-AMP-induced differentiation in neuroblastoma is independent of cell division rate. Waymire, J.C., Gilmer-Waymire, K., Haycock, J.W. Nature (1978) [Pubmed]
  17. Complementation of dominant suppression implicates CD98 in integrin activation. Fenczik, C.A., Sethi, T., Ramos, J.W., Hughes, P.E., Ginsberg, M.H. Nature (1997) [Pubmed]
  18. MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. Zhang, X., Krutchinsky, A., Fukuda, A., Chen, W., Yamamura, S., Chait, B.T., Roeder, R.G. Mol. Cell (2005) [Pubmed]
  19. Effects of retinoic acid versus dimethyl sulfoxide on Friend erythroleukemia cell growth. II. Induction of quiescent, nonproliferating cells. Traganos, F., Higgins, P.J., Bueti, C., Darzynkiewicz, Z., Melamed, M.R. J. Natl. Cancer Inst. (1984) [Pubmed]
  20. Computerized quantitation of synergism and antagonism of taxol, topotecan, and cisplatin against human teratocarcinoma cell growth: a rational approach to clinical protocol design. Chou, T.C., Motzer, R.J., Tong, Y., Bosl, G.J. J. Natl. Cancer Inst. (1994) [Pubmed]
  21. Proteolytic processing of histone H3 in chromatin: a physiologically regulated event in Tetrahymena micronuclei. Allis, C.D., Bowen, J.K., Abraham, G.N., Glover, C.V., Gorovsky, M.A. Cell (1980) [Pubmed]
  22. The EGF receptor defines domains of cell cycle progression and survival to regulate cell number in the developing Drosophila eye. Baker, N.E., Yu, S.Y. Cell (2001) [Pubmed]
  23. Fission yeast p13 blocks mitotic activation and tyrosine dephosphorylation of the Xenopus cdc2 protein kinase. Dunphy, W.G., Newport, J.W. Cell (1989) [Pubmed]
  24. The growth regulators warts/lats and melted interact in a bistable loop to specify opposite fates in Drosophila R8 photoreceptors. Mikeladze-Dvali, T., Wernet, M.F., Pistillo, D., Mazzoni, E.O., Teleman, A.A., Chen, Y.W., Cohen, S., Desplan, C. Cell (2005) [Pubmed]
  25. Microcell mediated chromosome transfer maps the Fanconi anaemia group D gene to chromosome 3p. Whitney, M., Thayer, M., Reifsteck, C., Olson, S., Smith, L., Jakobs, P.M., Leach, R., Naylor, S., Joenje, H., Grompe, M. Nat. Genet. (1995) [Pubmed]
  26. Miranda is required for the asymmetric localization of Prospero during mitosis in Drosophila. Shen, C.P., Jan, L.Y., Jan, Y.N. Cell (1997) [Pubmed]
  27. Cell cycle regulation of SW15 is required for mother-cell-specific HO transcription in yeast. Nasmyth, K., Seddon, A., Ammerer, G. Cell (1987) [Pubmed]
  28. Inhibition of MAP2 expression affects both morphological and cell division phenotypes of neuronal differentiation. Dinsmore, J.H., Solomon, F. Cell (1991) [Pubmed]
  29. Dyssegmental dysplasia, Silverman-Handmaker type, is caused by functional null mutations of the perlecan gene. Arikawa-Hirasawa, E., Wilcox, W.R., Le, A.H., Silverman, N., Govindraj, P., Hassell, J.R., Yamada, Y. Nat. Genet. (2001) [Pubmed]
  30. Drosophila fizzy-related down-regulates mitotic cyclins and is required for cell proliferation arrest and entry into endocycles. Sigrist, S.J., Lehner, C.F. Cell (1997) [Pubmed]
  31. Protein serine/threonine phosphatases: structure, regulation, and functions in cell growth. Mumby, M.C., Walter, G. Physiol. Rev. (1993) [Pubmed]
  32. Direct induction by estradiol on vitellogenin synthesis in organ cultures of male Xenopus laevis liver. Green, C.D., Tata, J.R. Cell (1976) [Pubmed]
  33. Studies on intercellular LETS glycoprotein matrices. Chen, L.B., Murray, A., Segal, R.A., Bushnell, A., Walsh, M.L. Cell (1978) [Pubmed]
  34. In vivo amplification of the androgen receptor gene and progression of human prostate cancer. Visakorpi, T., Hyytinen, E., Koivisto, P., Tanner, M., Keinänen, R., Palmberg, C., Palotie, A., Tammela, T., Isola, J., Kallioniemi, O.P. Nat. Genet. (1995) [Pubmed]
  35. Schwann cell growth factors. Raff, M.C., Abney, E., Brockes, J.P., Hornby-Smith, A. Cell (1978) [Pubmed]
  36. A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability. Woitach, J.T., Zhang, M., Niu, C.H., Thorgeirsson, S.S. Nat. Genet. (1998) [Pubmed]
  37. TSC2 mediates cellular energy response to control cell growth and survival. Inoki, K., Zhu, T., Guan, K.L. Cell (2003) [Pubmed]
  38. Inscuteable and Staufen mediate asymmetric localization and segregation of prospero RNA during Drosophila neuroblast cell divisions. Li, P., Yang, X., Wasser, M., Cai, Y., Chia, W. Cell (1997) [Pubmed]
  39. Oscillation of MPF is accompanied by periodic association between cdc25 and cdc2-cyclin B. Jessus, C., Beach, D. Cell (1992) [Pubmed]
  40. A candidate protein kinase C gene, PKC1, is required for the S. cerevisiae cell cycle. Levin, D.E., Fields, F.O., Kunisawa, R., Bishop, J.M., Thorner, J. Cell (1990) [Pubmed]
  41. Intrinsic lymphotoxin-beta receptor requirement for homeostasis of lymphoid tissue dendritic cells. Kabashima, K., Banks, T.A., Ansel, K.M., Lu, T.T., Ware, C.F., Cyster, J.G. Immunity (2005) [Pubmed]
  42. High levels of glucose-6-phosphatase gene and protein expression reflect an adaptive response in proliferating liver and diabetes. Haber, B.A., Chin, S., Chuang, E., Buikhuisen, W., Naji, A., Taub, R. J. Clin. Invest. (1995) [Pubmed]
  43. Serum levels of interleukin 6, a potent myeloma cell growth factor, as a reflect of disease severity in plasma cell dyscrasias. Bataille, R., Jourdan, M., Zhang, X.G., Klein, B. J. Clin. Invest. (1989) [Pubmed]
  44. Cholesterol inhibition, cancer, and chemotherapy. Buchwald, H. Lancet (1992) [Pubmed]
  45. Changes in organization of Crithidia fasciculata kinetoplast DNA replication proteins during the cell cycle. Johnson, C.E., Englund, P.T. J. Cell Biol. (1998) [Pubmed]
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