MeSH Review:
Protein Isoprenylation
- Targeting signal transduction for disease therapy. Levitzki, A. Curr. Opin. Cell Biol. (1996)
- Structural insights into the function of the Rab GDI superfamily. Wu, S.K., Zeng, K., Wilson, I.A., Balch, W.E. Trends Biochem. Sci. (1996)
- Biochemical genetics: examples of life after cloning. McInnes, R.R., Byers, P.H. Curr. Opin. Genet. Dev. (1993)
- In vivo requirement of protein prenylation for maintenance of retinal cytoarchitecture and photoreceptor structure. Pittler, S.J., Fliesler, S.J., Fisher, P.L., Keller, P.K., Rapp, L.M. J. Cell Biol. (1995)
- Inhibiting farnesylation reverses the nuclear morphology defect in a HeLa cell model for Hutchinson-Gilford progeria syndrome. Mallampalli, M.P., Huyer, G., Bendale, P., Gelb, M.H., Michaelis, S. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Protein prenylation: molecular mechanisms and functional consequences. Zhang, F.L., Casey, P.J. Annu. Rev. Biochem. (1996)
- Oxysterols: modulators of cholesterol metabolism and other processes. Schroepfer, G.J. Physiol. Rev. (2000)
- The 70 kDa S6 kinase complexes with and is activated by the Rho family G proteins Cdc42 and Rac1. Chou, M.M., Blenis, J. Cell (1996)
- Identification of the homologous beige and Chediak-Higashi syndrome genes. Barbosa, M.D., Nguyen, Q.A., Tchernev, V.T., Ashley, J.A., Detter, J.C., Blaydes, S.M., Brandt, S.J., Chotai, D., Hodgman, C., Solari, R.C., Lovett, M., Kingsmore, S.F. Nature (1996)
- The effect of posttranslational modifications on the interaction of Ras2 with adenylyl cyclase. Kuroda, Y., Suzuki, N., Kataoka, T. Science (1993)
- Farnesyltransferase inhibitor tipifarnib is well tolerated, induces stabilization of disease, and inhibits farnesylation and oncogenic/tumor survival pathways in patients with advanced multiple myeloma. Alsina, M., Fonseca, R., Wilson, E.F., Belle, A.N., Gerbino, E., Price-Troska, T., Overton, R.M., Ahmann, G., Bruzek, L.M., Adjei, A.A., Kaufmann, S.H., Wright, J.J., Sullivan, D., Djulbegovic, B., Cantor, A.B., Greipp, P.R., Dalton, W.S., Sebti, S.M. Blood (2004)
- The third-generation bisphosphonate zoledronate synergistically augments the anti-Ph+ leukemia activity of imatinib mesylate. Kuroda, J., Kimura, S., Segawa, H., Kobayashi, Y., Yoshikawa, T., Urasaki, Y., Ueda, T., Enjo, F., Tokuda, H., Ottmann, O.G., Maekawa, T. Blood (2003)
- Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras. Luckman, S.P., Hughes, D.E., Coxon, F.P., Graham, R., Russell, G., Rogers, M.J. J. Bone Miner. Res. (1998)
- 17 beta-Estradiol overcomes a G1 block induced by HMG-CoA reductase inhibitors and fosters cell cycle progression without inducing ERK-1 and -2 MAP kinases activation. Bonapace, I.M., Addeo, R., Altucci, L., Cicatiello, L., Bifulco, M., Laezza, C., Salzano, S., Sica, V., Bresciani, F., Weisz, A. Oncogene (1996)
- Preclinical antitumor activity and pharmacodynamic studies with the farnesyl protein transferase inhibitor R115777 in human breast cancer. Kelland, L.R., Smith, V., Valenti, M., Patterson, L., Clarke, P.A., Detre, S., End, D., Howes, A.J., Dowsett, M., Workman, P., Johnston, S.R. Clin. Cancer Res. (2001)
- Protein isoprenylation and methylation at carboxyl-terminal cysteine residues. Clarke, S. Annu. Rev. Biochem. (1992)
- Modification of nuclear lamin proteins by a mevalonic acid derivative occurs in reticulocyte lysates and requires the cysteine residue of the C-terminal CXXM motif. Vorburger, K., Kitten, G.T., Nigg, E.A. EMBO J. (1989)
- Pheromones trigger filamentous growth in Ustilago maydis. Spellig, T., Bölker, M., Lottspeich, F., Frank, R.W., Kahmann, R. EMBO J. (1994)
- Molecular basis for Rab prenylation. Alory, C., Balch, W.E. J. Cell Biol. (2000)
- A tagging-via-substrate technology for detection and proteomics of farnesylated proteins. Kho, Y., Kim, S.C., Jiang, C., Barma, D., Kwon, S.W., Cheng, J., Jaunbergs, J., Weinbaum, C., Tamanoi, F., Falck, J., Zhao, Y. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Independent degeneration of photoreceptors and retinal pigment epithelium in conditional knockout mouse models of choroideremia. Tolmachova, T., Anders, R., Abrink, M., Bugeon, L., Dallman, M.J., Futter, C.E., Ramalho, J.S., Tonagel, F., Tanimoto, N., Seeliger, M.W., Huxley, C., Seabra, M.C. J. Clin. Invest. (2006)
- Rab escort protein-1 is a multifunctional protein that accompanies newly prenylated rab proteins to their target membranes. Alexandrov, K., Horiuchi, H., Steele-Mortimer, O., Seabra, M.C., Zerial, M. EMBO J. (1994)
- ras isoprenylation is required for ras-induced but not for NGF-induced neuronal differentiation of PC12 cells. Qiu, M.S., Pitts, A.F., Winters, T.R., Green, S.H. J. Cell Biol. (1991)
- Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells. James, G.L., Goldstein, J.L., Brown, M.S., Rawson, T.E., Somers, T.C., McDowell, R.S., Crowley, C.W., Lucas, B.K., Levinson, A.D., Marsters, J.C. Science (1993)
- Isoprenoid metabolism is required for stimulation of the respiratory burst oxidase of HL-60 cells. Bokoch, G.M., Prossnitz, V. J. Clin. Invest. (1992)
- In vivo antiviral efficacy of prenylation inhibitors against hepatitis delta virus. Bordier, B.B., Ohkanda, J., Liu, P., Lee, S.Y., Salazar, F.H., Marion, P.L., Ohashi, K., Meuse, L., Kay, M.A., Casey, J.L., Sebti, S.M., Hamilton, A.D., Glenn, J.S. J. Clin. Invest. (2003)
- Lovastatin augments sulindac-induced apoptosis in colon cancer cells and potentiates chemopreventive effects of sulindac. Agarwal, B., Rao, C.V., Bhendwal, S., Ramey, W.R., Shirin, H., Reddy, B.S., Holt, P.R. Gastroenterology (1999)
- 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors reduce human pancreatic cancer cell invasion and metastasis. Kusama, T., Mukai, M., Iwasaki, T., Tatsuta, M., Matsumoto, Y., Akedo, H., Inoue, M., Nakamura, H. Gastroenterology (2002)
- Enzymatic coupling of cholesterol intermediates to a mating pheromone precursor and to the ras protein. Schafer, W.R., Trueblood, C.E., Yang, C.C., Mayer, M.P., Rosenberg, S., Poulter, C.D., Kim, S.H., Rine, J. Science (1990)
- Rab27a is required for regulated secretion in cytotoxic T lymphocytes. Stinchcombe, J.C., Barral, D.C., Mules, E.H., Booth, S., Hume, A.N., Machesky, L.M., Seabra, M.C., Griffiths, G.M. J. Cell Biol. (2001)
- Arabidopsis TOBAMOVIRUS MULTIPLICATION (TOM) 2 locus encodes a transmembrane protein that interacts with TOM1. Tsujimoto, Y., Numaga, T., Ohshima, K., Yano, M.A., Ohsawa, R., Goto, D.B., Naito, S., Ishikawa, M. EMBO J. (2003)
- Farnesol modification of Kirsten-ras exon 4B protein is essential for transformation. Jackson, J.H., Cochrane, C.G., Bourne, J.R., Solski, P.A., Buss, J.E., Der, C.J. Proc. Natl. Acad. Sci. U.S.A. (1990)
- Phase II and pharmacodynamic study of the farnesyltransferase inhibitor R115777 as initial therapy in patients with metastatic pancreatic adenocarcinoma. Cohen, S.J., Ho, L., Ranganathan, S., Abbruzzese, J.L., Alpaugh, R.K., Beard, M., Lewis, N.L., McLaughlin, S., Rogatko, A., Perez-Ruixo, J.J., Thistle, A.M., Verhaeghe, T., Wang, H., Weiner, L.M., Wright, J.J., Hudes, G.R., Meropol, N.J. J. Clin. Oncol. (2003)
- The farnesyl protein transferase inhibitor BZA-5B blocks farnesylation of nuclear lamins and p21ras but does not affect their function or localization. Dalton, M.B., Fantle, K.S., Bechtold, H.A., DeMaio, L., Evans, R.M., Krystosek, A., Sinensky, M. Cancer Res. (1995)
- Biochemical characterization and subcellular localization of the mouse retinitis pigmentosa GTPase regulator (mRpgr). Yan, D., Swain, P.K., Breuer, D., Tucker, R.M., Wu, W., Fujita, R., Rehemtulla, A., Burke, D., Swaroop, A. J. Biol. Chem. (1998)
- The farnesyl transferase inhibitor (FTI) SCH66336 (lonafarnib) inhibits Rheb farnesylation and mTOR signaling. Role in FTI enhancement of taxane and tamoxifen anti-tumor activity. Basso, A.D., Mirza, A., Liu, G., Long, B.J., Bishop, W.R., Kirschmeier, P. J. Biol. Chem. (2005)
- Expression and mutagenesis of mouse rod photoreceptor cGMP phosphodiesterase. Qin, N., Baehr, W. J. Biol. Chem. (1994)