The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Psychopathology


Psychiatry related information on Psychopathology


High impact information on Psychopathology

  • AVP also has facilitatory effects on cognitive function in humans, and marked deficits in AVP function have been associated with certain types of psychopathology [11].
  • OBJECTIVE: To test a priori hypotheses that olanzapine-treated patients have less change over time in whole brain gray matter volumes and lateral ventricle volumes than haloperidol-treated patients and that gray matter and lateral ventricle volume changes are associated with changes in psychopathology and neurocognition [12].
  • METHODS: Probands included 268 adolescents with a history of MDD, 110 adolescents with a history of nonmood disorders but no history of MDD through age 18 years, and 291 adolescents with no history of psychopathology through age 18 years [13].
  • BACKGROUND: As children with velocardiofacial syndrome (VCFS) develop, they are at increased risk for psychopathology; one third will eventually develop schizophrenia [14].
  • Homosexuality, psychopathology, and suicidality [15].

Chemical compound and disease context of Psychopathology


Biological context of Psychopathology


Anatomical context of Psychopathology


Gene context of Psychopathology

  • Catechol-O-methyltransferase (COMT) is one of the major mammalian enzymes involved in the metabolic degradation of catecholamines and is considered a candidate for several psychiatric disorders and symptoms, including the psychopathology associated with the 22q11 microdeletion syndrome [30].
  • The presence of high concentrations of both cholecystokinin and opioids in the striatum also suggests that these peptides not only may influence dopaminergic transmission, but that they may also be relevant to the psychopathology of schizophrenia and to the therapeutic effects of neuroleptics [31].
  • With regard to psychopathology, negative symptomatology appears to be the predicting factor for the absolute S100B concentration [32].
  • Elevated interleukin-2, interleukin-6 and interleukin-8 serum levels in neuroleptic-free schizophrenia: association with psychopathology [33].
  • Hence, an exaggerated cortisol response in the combined DEX/CRH test predicts the recurrence of depressive psychopathology [34].

Analytical, diagnostic and therapeutic context of Psychopathology


  1. Lateralized neurologic deficits and psychopathology in a Turner syndrome patient. Kolb, J.E., Heaton, R.K. Arch. Gen. Psychiatry (1975) [Pubmed]
  2. Effect of hearing enhancement on mental status ratings in geriatric psychiatric patients. Kreeger, J.L., Raulin, M.L., Grace, J., Priest, B.L. The American journal of psychiatry. (1995) [Pubmed]
  3. Methylphenidate response, psychopathology and tardive dyskinesia as predictors of relapse in schizophrenia. Lieberman, J.A., Alvir, J., Geisler, S., Ramos-Lorenzi, J., Woerner, M., Novacenko, H., Cooper, T., Kane, J.M. Neuropsychopharmacology (1994) [Pubmed]
  4. The DSM-III concepts of schizophrenic disorder and schizophreniform disorder. A clinical and prognostic evaluation. Makanjuola, R.O., Adedapo, S.A. The British journal of psychiatry : the journal of mental science. (1987) [Pubmed]
  5. Weekly monitoring of dexamethasone suppression response in depression: its relationship to change of body weight and psychopathology. Gerken, A., Maier, W., Holsboer, F. Psychoneuroendocrinology (1985) [Pubmed]
  6. Neuroendocrine response to 5-hydroxy-L-tryptophan in prepubertal children at high risk of major depressive disorder. Birmaher, B., Kaufman, J., Brent, D.A., Dahl, R.E., Perel, J.M., al-Shabbout, M., Nelson, B., Stull, S., Rao, U., Waterman, G.S., Williamson, D.E., Ryan, N.D. Arch. Gen. Psychiatry (1997) [Pubmed]
  7. Switching from 'unipolar' to bipolar II. An 11-year prospective study of clinical and temperamental predictors in 559 patients. Akiskal, H.S., Maser, J.D., Zeller, P.J., Endicott, J., Coryell, W., Keller, M., Warshaw, M., Clayton, P., Goodwin, F. Arch. Gen. Psychiatry (1995) [Pubmed]
  8. 5-HT2A and 5-HT2C receptor polymorphisms and psychopathology in late onset Alzheimer's disease. Holmes, C., Arranz, M.J., Powell, J.F., Collier, D.A., Lovestone, S. Hum. Mol. Genet. (1998) [Pubmed]
  9. Social networks and psychopathology among substance abusers. Westermeyer, J., Neider, J. The American journal of psychiatry. (1988) [Pubmed]
  10. CSF neurotensin concentrations and antipsychotic treatment in schizophrenia and schizoaffective disorder. Sharma, R.P., Janicak, P.G., Bissette, G., Nemeroff, C.B. The American journal of psychiatry. (1997) [Pubmed]
  11. Osmotic stress mimics effects of vasopressin on learned behaviour. Koob, G.F., Dantzer, R., Rodriguez, F., Bloom, F.E., Le Moal, M. Nature (1985) [Pubmed]
  12. Antipsychotic drug effects on brain morphology in first-episode psychosis. Lieberman, J.A., Tollefson, G.D., Charles, C., Zipursky, R., Sharma, T., Kahn, R.S., Keefe, R.S., Green, A.I., Gur, R.E., McEvoy, J., Perkins, D., Hamer, R.M., Gu, H., Tohen, M. Arch. Gen. Psychiatry (2005) [Pubmed]
  13. A family study of major depressive disorder in a community sample of adolescents. Klein, D.N., Lewinsohn, P.M., Seeley, J.R., Rohde, P. Arch. Gen. Psychiatry (2001) [Pubmed]
  14. Parental origin of the deletion 22q11.2 and brain development in velocardiofacial syndrome: a preliminary study. Eliez, S., Antonarakis, S.E., Morris, M.A., Dahoun, S.P., Reiss, A.L. Arch. Gen. Psychiatry (2001) [Pubmed]
  15. Homosexuality, psychopathology, and suicidality. Friedman, R.C. Arch. Gen. Psychiatry (1999) [Pubmed]
  16. Serotonergic responsivity in obsessive-compulsive disorder. Comparison of patients and healthy controls. Zohar, J., Mueller, E.A., Insel, T.R., Zohar-Kadouch, R.C., Murphy, D.L. Arch. Gen. Psychiatry (1987) [Pubmed]
  17. Dopamine excretion and vulnerability to drug-induced Parkinsonism. Schizophrenic patients. Crowley, T.J., Hoehn, M.M., Rutledge, C.O., Stallings, M.A., Heaton, R.K., Sundell, S., Stilson, D. Arch. Gen. Psychiatry (1978) [Pubmed]
  18. Skeletal muscle MAO activity in the major psychoses. Relationship with platelet and plasma MAO activities. Meltzer, H.Y., Arora, R.C. Arch. Gen. Psychiatry (1980) [Pubmed]
  19. Plasma homovanillic acid levels in first-episode schizophrenia. Psychopathology and treatment response. Koreen, A.R., Lieberman, J., Alvir, J., Mayerhoff, D., Loebel, A., Chakos, M., Amin, F., Cooper, T. Arch. Gen. Psychiatry (1994) [Pubmed]
  20. Self-mutilation in personality disorders: psychological and biological correlates. Simeon, D., Stanley, B., Frances, A., Mann, J.J., Winchel, R., Stanley, M. The American journal of psychiatry. (1992) [Pubmed]
  21. Association of serotonin 5-HT2A receptor binding and the T102C polymorphism in depressed and healthy Caucasian subjects. Khait, V.D., Huang, Y.Y., Zalsman, G., Oquendo, M.A., Brent, D.A., Harkavy-Friedman, J.M., Mann, J.J. Neuropsychopharmacology (2005) [Pubmed]
  22. The Gilles de la Tourette syndrome: the current status. Robertson, M.M. The British journal of psychiatry : the journal of mental science. (1989) [Pubmed]
  23. The efficacy of olanzapine for decreasing cue-elicited craving in individuals with schizophrenia and cocaine dependence: a preliminary report. Smelson, D.A., Ziedonis, D., Williams, J., Losonczy, M.F., Williams, J., Steinberg, M.L., Kaune, M. Journal of clinical psychopharmacology. (2006) [Pubmed]
  24. Relationship between interictal psychopathology and the type of epilepsy. Results of a survey in general practice. Edeh, J., Toone, B. The British journal of psychiatry : the journal of mental science. (1987) [Pubmed]
  25. Interictal behavior abnormality in temporal lobe epilepsy. A specific syndrome or nonspecific psychopathology? Mungas, D. Arch. Gen. Psychiatry (1982) [Pubmed]
  26. Right amygdala volume in adolescent and young adult offspring from families at high risk for developing alcoholism. Hill, S.Y., De Bellis, M.D., Keshavan, M.S., Lowers, L., Shen, S., Hall, J., Pitts, T. Biol. Psychiatry (2001) [Pubmed]
  27. Decreased levels of soluble intercellular adhesion molecule-1 (sICAM-1) in unmedicated and medicated schizophrenic patients. Schwarz, M.J., Riedel, M., Ackenheil, M., Müller, N. Biol. Psychiatry (2000) [Pubmed]
  28. Predicting haloperidol treatment response in chronic schizophrenia. van Kammen, D.P., Kelley, M.E., Yao, J.K., Gilbertson, M.W., Gurklis, J.A., Inosaka, T., Saito, H., Peters, J.L., Sato, M. Psychiatry research. (1996) [Pubmed]
  29. Autoantibodies against 60-kDa heat shock protein in schizophrenia. Schwarz, M.J., Riedel, M., Gruber, R., Müller, N., Ackenheil, M. European archives of psychiatry and clinical neuroscience. (1998) [Pubmed]
  30. Catechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior. Gogos, J.A., Morgan, M., Luine, V., Santha, M., Ogawa, S., Pfaff, D., Karayiorgou, M. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  31. Dopamine, GABA, cholecystokinin and opioids in neuroleptic-induced tardive dyskinesia. Ebadi, M., Hama, Y. Neuroscience and biobehavioral reviews. (1988) [Pubmed]
  32. S100B serum levels and long-term improvement of negative symptoms in patients with schizophrenia. Rothermundt, M., Ponath, G., Glaser, T., Hetzel, G., Arolt, V. Neuropsychopharmacology (2004) [Pubmed]
  33. Elevated interleukin-2, interleukin-6 and interleukin-8 serum levels in neuroleptic-free schizophrenia: association with psychopathology. Zhang, X.Y., Zhou, D.F., Zhang, P.Y., Wu, G.Y., Cao, L.Y., Shen, Y.C. Schizophr. Res. (2002) [Pubmed]
  34. Cortisol response in the combined dexamethasone/CRH test as predictor of relapse in patients with remitted depression. a prospective study. Zobel, A.W., Nickel, T., Sonntag, A., Uhr, M., Holsboer, F., Ising, M. Journal of psychiatric research. (2001) [Pubmed]
  35. Vulnerability to psychopathology in nicotine-dependent smokers: an epidemiologic study of young adults. Breslau, N., Kilbey, M.M., Andreski, P. The American journal of psychiatry. (1993) [Pubmed]
  36. Intravenous administration of the neuropeptide galanin has fast antidepressant efficacy and affects the sleep EEG. Murck, H., Held, K., Ziegenbein, M., Künzel, H., Holsboer, F., Steiger, A. Psychoneuroendocrinology (2004) [Pubmed]
  37. Auditory P300 amplitude as a state marker for positive symptoms in schizophrenia: cross-sectional and retrospective longitudinal studies. Higashima, M., Nagasawa, T., Kawasaki, Y., Oka, T., Sakai, N., Tsukada, T., Koshino, Y. Schizophr. Res. (2003) [Pubmed]
  38. Illicit anabolic steroid use: a controlled personality study. Yates, W.R., Perry, P.J., Andersen, K.H. Acta psychiatrica Scandinavica. (1990) [Pubmed]
  39. Metabolic hyperfrontality and psychopathology in the ketamine model of psychosis using positron emission tomography (PET) and [18F]fluorodeoxyglucose (FDG). Vollenweider, F.X., Leenders, K.L., Scharfetter, C., Antonini, A., Maguire, P., Missimer, J., Angst, J. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. (1997) [Pubmed]
WikiGenes - Universities