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MeSH Review

Prefrontal Cortex

 
 
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Disease relevance of Prefrontal Cortex

 

Psychiatry related information on Prefrontal Cortex

 

High impact information on Prefrontal Cortex

  • Among the regions of the brain with the greatest reductions in glucose metabolism were the premotor cortex and the superior prefrontal cortex [11].
  • Here we examine the regulation of striatal dopamine by the dorsolateral prefrontal cortex, in adult monkeys that had had either neonatal or adult lesions of the medial-temporal lobe and in normal animals [12].
  • This reduction was related to the severity of the negative symptoms (for instance, emotional withdrawal) and to poor performance in the Wisconsin Card Sorting Test. We propose that dysfunction of D1R signalling in the prefrontal cortex may contribute to the negative symptoms and cognitive deficits seen in schizophrenia [13].
  • Using positron emission tomographic (PET) images of cerebral blood flow and rate of glucose metabolism to measure brain activity, we have now localized an area of abnormally decreased activity in the prefrontal cortex ventral to the genu of the corpus callosum in both familial bipolar depressives and familial unipolar depressives [14].
  • Calcyon localizes to dendritic spines of D1 receptor-expressing pyramidal cells in prefrontal cortex [15].
 

Chemical compound and disease context of Prefrontal Cortex

 

Biological context of Prefrontal Cortex

 

Anatomical context of Prefrontal Cortex

 

Associations of Prefrontal Cortex with chemical compounds

  • Monkeys treated with phencyclidine twice a day for 14 days displayed performance deficits on a task that was sensitive to prefrontal cortex function; the deficits were ameliorated by the atypical antipsychotic drug clozapine [21].
  • The tight within-patient coupling of these values, with decreased PFC activation predicting exaggerated striatal 6-fluorodopa uptake, supports the hypothesis that prefrontal cortex dysfunction may lead to dopaminergic transmission abnormalities [31].
  • Altered editing of serotonin 2C receptor pre-mRNA in the prefrontal cortex of depressed suicide victims [32].
  • Here, we report that the expression of AGS3, which binds to GialphaGDP and inhibits GDP dissociation, was upregulated in the prefrontal cortex (PFC) during late withdrawal from repeated cocaine administration [33].
  • This article aims to review research in nonhuman primates demonstrating that norepinephrine can enhance the cognitive functioning of the prefrontal cortex through actions at alpha 2 A-adrenergic receptors postjunctional to noradrenergic terminals [34].
 

Gene context of Prefrontal Cortex

 

Analytical, diagnostic and therapeutic context of Prefrontal Cortex

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