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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Fatal Outcome

 
 
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Disease relevance of Fatal Outcome

 

High impact information on Fatal Outcome

 

Chemical compound and disease context of Fatal Outcome

 

Biological context of Fatal Outcome

  • In patients who did not have a transplant, a fatal outcome was seen for 26/82 (32%), and was associated with late presentation, coma grade, prothrombin time prolongation, metabolic acidosis, and renal dysfunction [16].
  • BACKGROUND: Progress in molecular genetics has led to the identification of point mutations in the transthyretin (TTR) gene in FAP--a dominantly inherited neuropathy with a fatal outcome [17].
  • A significant association (P<.001) was found between fatal outcome and genotype at IL1B (nucleotide position -511) [18].
  • The fatal outcome of K virus infection in infant mice and cytoxan-treated adult mice is related to their inability to mount a prompt antibody response to the virus [19].
  • The following histopathologic features (in order of decreasing significance) were correlated with poor prognosis (recurrency or fatal outcome): less than 50% of the tumor cells heavily positive for S100, presence of mitoses, absence of TTR-positive cells, brain invasion by cell nests, absence of marked stromal edema, and presence of necrotic areas [20].
 

Anatomical context of Fatal Outcome

 

Associations of Fatal Outcome with chemical compounds

 

Gene context of Fatal Outcome

  • A few deviations from the reference sequences were identified; most interestingly being a splice site mutation that was detected in UBE4B/UFD2 in a stage 3 NBL with a fatal outcome [30].
  • We conclude that increased concentrations of cytokines and soluble cytokine receptors represent a normal host response to P. falciparum infections but that excessive secretion of cytokines like IL-6 may predispose to cerebral malaria and a fatal outcome while beta-2-glycoprotein I may protect against a fatal outcome of cerebral malaria [31].
  • CONCLUSIONS: In septic patients, high amounts of circulating IL-8 concentrations correlate with fatal outcome, whereas only low plasma concentrations of IL-8 are present in patients with nonseptic, multiple organ failure [32].
  • Molecular analysis revealed a hitherto undescribed combined pharmacogenetic syndrome, consisting of heterozygosity for the DPD IVS14+1 G > A mutation and UGT1A1 (TA)(6/7) heterozygosity, which probably contributed to the fatal outcome in this patient [33].
  • Notably, primary tumors with intense mRNA signal for TIMP-2 (No = 14) were uniformly associated with a fatal outcome [34].
 

Analytical, diagnostic and therapeutic context of Fatal Outcome

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