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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Carcinoma, Embryonal

 
 
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Disease relevance of Carcinoma, Embryonal

 

Psychiatry related information on Carcinoma, Embryonal

 

High impact information on Carcinoma, Embryonal

 

Chemical compound and disease context of Carcinoma, Embryonal

 

Biological context of Carcinoma, Embryonal

 

Anatomical context of Carcinoma, Embryonal

 

Gene context of Carcinoma, Embryonal

  • To test whether overexpression of APP generates abnormally processed derivatives that affect the viability of neurons, we stably transfected full-length human APP complementary DNA into murine embryonal carcinoma P19 cells [28].
  • Here, we show that in P19 embryonal carcinoma (EC) nuclei, HP1 alpha, beta, and gamma form homo- and heteromers associated with nucleosomal core histones [29].
  • Using F9 embryonal carcinoma (EC) cells and ES-5 embryonic stem (ES) cells as in vitro models, we demonstrate that during the differentiation of these cells towards primitive and parietal endoderm-like phenotypes, PTH/PTHrP-receptor mRNA is induced [30].
  • The retinoblastoma (RB) protein is present at low levels in early mouse embryos and in pluripotent P19 embryonal carcinoma cells; however, the levels of RB rise dramatically in neuroectoderm formed both in embryos and in differentiating cultures of P19 cells [31].
  • The full-length cDNA corresponding to Stra8, a novel gene inducible by retinoic acid (RA) in P19 embryonal carcinoma cells, has been isolated and shown to encode a 45-kD protein [32].
 

Analytical, diagnostic and therapeutic context of Carcinoma, Embryonal

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